Cultured sympathetic neurons express functional interleukin-1 receptors
Since recent work has identified an apoptotic pathway in sympathetic neurons that is mediated by autocrine interleukin-1 (IL-1), we investigated whether cultured sympathetic neurons possess functional IL-1 receptors. Cultured sympathetic neurons express levels of IL-1RI and IL-1RAcP mRNAs consistent...
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| Veröffentlicht in: | Journal of neuroimmunology 1998-11, Vol.91 (1), p.43-54 |
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| container_title | Journal of neuroimmunology |
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| creator | Bai, Yuchen Hart, Ronald P. |
| description | Since recent work has identified an apoptotic pathway in sympathetic neurons that is mediated by autocrine interleukin-1 (IL-1), we investigated whether cultured sympathetic neurons possess functional IL-1 receptors. Cultured sympathetic neurons express levels of IL-1RI and IL-1RAcP mRNAs consistent with signal transduction. Neurons stimulated with IL-1 demonstrate enhanced p65 NF-κB nuclear translocation and enhanced NF-κB DNA binding activity, with at least p65 and p50 subunits participating in the DNA binding activity. RNA differential display identified several neuronal mRNAs regulated by IL-1, including a member of the reticulon family. We conclude that IL-1 stimulates a potential component of a neuronal secretory pathway. |
| doi_str_mv | 10.1016/S0165-5728(98)00149-0 |
| format | Article |
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Cultured sympathetic neurons express levels of IL-1RI and IL-1RAcP mRNAs consistent with signal transduction. Neurons stimulated with IL-1 demonstrate enhanced p65 NF-κB nuclear translocation and enhanced NF-κB DNA binding activity, with at least p65 and p50 subunits participating in the DNA binding activity. RNA differential display identified several neuronal mRNAs regulated by IL-1, including a member of the reticulon family. 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Cultured sympathetic neurons express levels of IL-1RI and IL-1RAcP mRNAs consistent with signal transduction. Neurons stimulated with IL-1 demonstrate enhanced p65 NF-κB nuclear translocation and enhanced NF-κB DNA binding activity, with at least p65 and p50 subunits participating in the DNA binding activity. RNA differential display identified several neuronal mRNAs regulated by IL-1, including a member of the reticulon family. We conclude that IL-1 stimulates a potential component of a neuronal secretory pathway.</description><subject>Animals</subject><subject>Apoptosis - immunology</subject><subject>Autocrine Communication - immunology</subject><subject>Cells, Cultured</subject><subject>DNA, Complementary</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Functional interleukin-1 receptor</subject><subject>Gene Expression - immunology</subject><subject>IL-1RAcp</subject><subject>IL-1RI</subject><subject>Interleukin-1 Receptor-Associated Kinases</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>MAP Kinase Kinase 4</subject><subject>Mitogen-Activated Protein Kinase Kinases</subject><subject>Neurons - cytology</subject><subject>Neurons - immunology</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - immunology</subject><subject>Protein Kinases - immunology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Interleukin-1 - genetics</subject><subject>Receptors, Interleukin-1 - immunology</subject><subject>RNA, Messenger - analysis</subject><subject>Signal Transduction - immunology</subject><subject>Superior Cervical Ganglion - cytology</subject><subject>Superior Cervical Ganglion - immunology</subject><subject>Sympathetic neuron</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EKqXwEyplQjAEfGkS2xNCFRSkSgx0txz7LAxpEmwH0X9P-qGuLHfD-7x30kPIFOgdUCjv34dRpAXL-I3gt5RCLlJ6QsbAWZbyPINTMj4i5-QihM8BKma5GJGR4HnJgY_JYt7XsfdokrBZdyp-YHQ6abD3bRMS_O08hpDYvtHRtY2qE9dE9DX2X65JIfGosYutD5fkzKo64NVhT8jq-Wk1f0mXb4vX-eMy1TMBMbUMLWN8VnJr86w0AoTmwHJLc5MhpVWGhcpLXRUcVKXAMKvVwFFjeEbL2YRc7892vv3uMUS5dkFjXasG2z5IRoFyKLJ_QWBAqSj5ABZ7UPs2BI9Wdt6tld9IoHIrWu5Ey61FKbjciZZ06E0PD_pqjebYOpgd8od9joONH4deBu2w0WjcIC1K07p_PvwBMaKOSQ</recordid><startdate>19981102</startdate><enddate>19981102</enddate><creator>Bai, Yuchen</creator><creator>Hart, Ronald P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19981102</creationdate><title>Cultured sympathetic neurons express functional interleukin-1 receptors</title><author>Bai, Yuchen ; Hart, Ronald P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f7ef778368ff426d919c8174f04d2e00b2e5a46cb581aba1d7fca26d0dd82063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Apoptosis - immunology</topic><topic>Autocrine Communication - immunology</topic><topic>Cells, Cultured</topic><topic>DNA, Complementary</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Functional interleukin-1 receptor</topic><topic>Gene Expression - immunology</topic><topic>IL-1RAcp</topic><topic>IL-1RI</topic><topic>Interleukin-1 Receptor-Associated Kinases</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>MAP Kinase Kinase 4</topic><topic>Mitogen-Activated Protein Kinase Kinases</topic><topic>Neurons - cytology</topic><topic>Neurons - immunology</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - immunology</topic><topic>Protein Kinases - immunology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Interleukin-1 - genetics</topic><topic>Receptors, Interleukin-1 - immunology</topic><topic>RNA, Messenger - analysis</topic><topic>Signal Transduction - immunology</topic><topic>Superior Cervical Ganglion - cytology</topic><topic>Superior Cervical Ganglion - immunology</topic><topic>Sympathetic neuron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Yuchen</creatorcontrib><creatorcontrib>Hart, Ronald P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Yuchen</au><au>Hart, Ronald P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cultured sympathetic neurons express functional interleukin-1 receptors</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1998-11-02</date><risdate>1998</risdate><volume>91</volume><issue>1</issue><spage>43</spage><epage>54</epage><pages>43-54</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Since recent work has identified an apoptotic pathway in sympathetic neurons that is mediated by autocrine interleukin-1 (IL-1), we investigated whether cultured sympathetic neurons possess functional IL-1 receptors. Cultured sympathetic neurons express levels of IL-1RI and IL-1RAcP mRNAs consistent with signal transduction. Neurons stimulated with IL-1 demonstrate enhanced p65 NF-κB nuclear translocation and enhanced NF-κB DNA binding activity, with at least p65 and p50 subunits participating in the DNA binding activity. RNA differential display identified several neuronal mRNAs regulated by IL-1, including a member of the reticulon family. We conclude that IL-1 stimulates a potential component of a neuronal secretory pathway.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9846818</pmid><doi>10.1016/S0165-5728(98)00149-0</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 1998-11, Vol.91 (1), p.43-54 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Apoptosis - immunology Autocrine Communication - immunology Cells, Cultured DNA, Complementary DNA-Binding Proteins - immunology Functional interleukin-1 receptor Gene Expression - immunology IL-1RAcp IL-1RI Interleukin-1 Receptor-Associated Kinases JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases Neurons - cytology Neurons - immunology NF-kappa B - genetics NF-kappa B - immunology Protein Kinases - immunology Rats Rats, Sprague-Dawley Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - immunology RNA, Messenger - analysis Signal Transduction - immunology Superior Cervical Ganglion - cytology Superior Cervical Ganglion - immunology Sympathetic neuron |
| title | Cultured sympathetic neurons express functional interleukin-1 receptors |
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