Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of Venous Thromboembolic Complications
Background: Central venous lines (CVLs) are frequently associated with deep venous thrombosis (DVT) in children; however, little is known about the epidemiologic characteristics or outcome of CVL-related DVT. Methods: The Canadian Childhood Thrombophilia Registry monitored 244 consecutive patients w...
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| Veröffentlicht in: | The Journal of pediatrics 1998-12, Vol.133 (6), p.770-776 |
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| creator | Massicotte, M.Patricia Dix, David Monagle, Paul Adams, Margaret Andrew, Maureen |
| description | Background: Central venous lines (CVLs) are frequently associated with deep venous thrombosis (DVT) in children; however, little is known about the epidemiologic characteristics or outcome of CVL-related DVT.
Methods: The Canadian Childhood Thrombophilia Registry monitored 244 consecutive patients with objectively diagnosed CVL-related DVT for a median duration of 24 months (range 3 months to 7 years).
Results: The incidence of CVL-related DVT was 3.5 per 10,000 hospital admissions. CVL-related DVTs were more frequent in the upper venous system. Ultrasonography or echocardiography were the most commonly used diagnostic tests (n = 183 patients). Venograms were performed on 82 (34%) patients. A variety of therapies were used. Thirty-nine children had pulmonary emboli, but most were not investigated for pulmonary emboli. Nine (3.7%) children died as a consequence of their thromboembolic disease. Recurrent DVT occurred in 16 (6.5%) children, and postphlebitic syndrome occurred in 23 (9.5%) children.
Conclusion: Currently no uniform guidelines exist for the prevention and management of CVL-related DVT in children. The frequency and clinical consequences of CVL-related DVTs justify controlled trials of primary prophylaxis in children requiring central venous access. (J Pediatr 1998;133:770-6) |
| doi_str_mv | 10.1016/S0022-3476(98)70149-0 |
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Methods: The Canadian Childhood Thrombophilia Registry monitored 244 consecutive patients with objectively diagnosed CVL-related DVT for a median duration of 24 months (range 3 months to 7 years).
Results: The incidence of CVL-related DVT was 3.5 per 10,000 hospital admissions. CVL-related DVTs were more frequent in the upper venous system. Ultrasonography or echocardiography were the most commonly used diagnostic tests (n = 183 patients). Venograms were performed on 82 (34%) patients. A variety of therapies were used. Thirty-nine children had pulmonary emboli, but most were not investigated for pulmonary emboli. Nine (3.7%) children died as a consequence of their thromboembolic disease. Recurrent DVT occurred in 16 (6.5%) children, and postphlebitic syndrome occurred in 23 (9.5%) children.
Conclusion: Currently no uniform guidelines exist for the prevention and management of CVL-related DVT in children. The frequency and clinical consequences of CVL-related DVTs justify controlled trials of primary prophylaxis in children requiring central venous access. (J Pediatr 1998;133:770-6)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(98)70149-0</identifier><identifier>PMID: 9842042</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Age Distribution ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Canada - epidemiology ; Catheterization, Central Venous - adverse effects ; Child ; Child, Preschool ; Cohort Studies ; Emergency and intensive care: techniques, logistics ; Female ; Humans ; Incidence ; Infant ; Intensive care medicine ; Male ; Medical sciences ; Perfusions. Catheterizations. Hyperbaric oxygenotherapy ; Registries ; Retrospective Studies ; Venous Thrombosis - epidemiology ; Venous Thrombosis - etiology</subject><ispartof>The Journal of pediatrics, 1998-12, Vol.133 (6), p.770-776</ispartof><rights>1998 Mosby, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Mosby-Year Book, Inc. Dec 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8e6237feac6f55e49feca02606cc417491c6729b8fba4ebae5e43622c17c0a23</citedby><cites>FETCH-LOGICAL-c416t-8e6237feac6f55e49feca02606cc417491c6729b8fba4ebae5e43622c17c0a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(98)70149-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1620218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9842042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massicotte, M.Patricia</creatorcontrib><creatorcontrib>Dix, David</creatorcontrib><creatorcontrib>Monagle, Paul</creatorcontrib><creatorcontrib>Adams, Margaret</creatorcontrib><creatorcontrib>Andrew, Maureen</creatorcontrib><creatorcontrib>on behalf of the Canadian Childhood Thrombophilia Program</creatorcontrib><title>Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of Venous Thromboembolic Complications</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Background: Central venous lines (CVLs) are frequently associated with deep venous thrombosis (DVT) in children; however, little is known about the epidemiologic characteristics or outcome of CVL-related DVT.
Methods: The Canadian Childhood Thrombophilia Registry monitored 244 consecutive patients with objectively diagnosed CVL-related DVT for a median duration of 24 months (range 3 months to 7 years).
Results: The incidence of CVL-related DVT was 3.5 per 10,000 hospital admissions. CVL-related DVTs were more frequent in the upper venous system. Ultrasonography or echocardiography were the most commonly used diagnostic tests (n = 183 patients). Venograms were performed on 82 (34%) patients. A variety of therapies were used. Thirty-nine children had pulmonary emboli, but most were not investigated for pulmonary emboli. Nine (3.7%) children died as a consequence of their thromboembolic disease. Recurrent DVT occurred in 16 (6.5%) children, and postphlebitic syndrome occurred in 23 (9.5%) children.
Conclusion: Currently no uniform guidelines exist for the prevention and management of CVL-related DVT in children. The frequency and clinical consequences of CVL-related DVTs justify controlled trials of primary prophylaxis in children requiring central venous access. (J Pediatr 1998;133:770-6)</description><subject>Adolescent</subject><subject>Age Distribution</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Canada - epidemiology</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - etiology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFrFDEUhYModa3-hEIQEX0YvclkMxNfpAytCgVBF19DJnPHTZlN1iRb2Dd_upnOUsEXH8KFnC-Hm3MIuWDwjgGT778DcF7VopFvVPu2ASZUBY_IioFqKtnW9WOyekCekmcp3QKAEgBn5Ey1goPgK_K7Q5-jmegd-nBI1Jq8xYyRRpxMxoHmbQy7PiSXqPPUbt00RPQf6KU303G-DWNhkHbGm8EZT7_hT5dyPM7Cj8V0s3hgOZOztAu7fZkmu-DTc_JkNFPCF6d5TjbXV5vuc3Xz9dOX7vKmsoLJXLUoed2MaKwc12sUakRrgEuQtgCNUMzKhqu-HXsjsDdYmFpyblljwfD6nLxebPcx_DpgynrnksVpMh7LirrkB8UFCvjyH_A2HGL5bNJMiUaU4JoCrRfIxpBSxFHvo9uZeNQM9NyOvm9Hz9Fr1er7dvRsfnEyP_Q7HB5eneoo-quTbpI10xiNty79NZccOGsL9nHBsAR25zDqZB16i4OLaLMegvvPIn8Aor6tjA</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Massicotte, M.Patricia</creator><creator>Dix, David</creator><creator>Monagle, Paul</creator><creator>Adams, Margaret</creator><creator>Andrew, Maureen</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Mosby-Year Book, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of Venous Thromboembolic Complications</title><author>Massicotte, M.Patricia ; Dix, David ; Monagle, Paul ; Adams, Margaret ; Andrew, Maureen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-8e6237feac6f55e49feca02606cc417491c6729b8fba4ebae5e43622c17c0a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Age Distribution</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Canada - epidemiology</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Emergency and intensive care: techniques, logistics</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Perfusions. Catheterizations. Hyperbaric oxygenotherapy</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massicotte, M.Patricia</creatorcontrib><creatorcontrib>Dix, David</creatorcontrib><creatorcontrib>Monagle, Paul</creatorcontrib><creatorcontrib>Adams, Margaret</creatorcontrib><creatorcontrib>Andrew, Maureen</creatorcontrib><creatorcontrib>on behalf of the Canadian Childhood Thrombophilia Program</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massicotte, M.Patricia</au><au>Dix, David</au><au>Monagle, Paul</au><au>Adams, Margaret</au><au>Andrew, Maureen</au><aucorp>on behalf of the Canadian Childhood Thrombophilia Program</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of Venous Thromboembolic Complications</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>133</volume><issue>6</issue><spage>770</spage><epage>776</epage><pages>770-776</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Background: Central venous lines (CVLs) are frequently associated with deep venous thrombosis (DVT) in children; however, little is known about the epidemiologic characteristics or outcome of CVL-related DVT.
Methods: The Canadian Childhood Thrombophilia Registry monitored 244 consecutive patients with objectively diagnosed CVL-related DVT for a median duration of 24 months (range 3 months to 7 years).
Results: The incidence of CVL-related DVT was 3.5 per 10,000 hospital admissions. CVL-related DVTs were more frequent in the upper venous system. Ultrasonography or echocardiography were the most commonly used diagnostic tests (n = 183 patients). Venograms were performed on 82 (34%) patients. A variety of therapies were used. Thirty-nine children had pulmonary emboli, but most were not investigated for pulmonary emboli. Nine (3.7%) children died as a consequence of their thromboembolic disease. Recurrent DVT occurred in 16 (6.5%) children, and postphlebitic syndrome occurred in 23 (9.5%) children.
Conclusion: Currently no uniform guidelines exist for the prevention and management of CVL-related DVT in children. The frequency and clinical consequences of CVL-related DVTs justify controlled trials of primary prophylaxis in children requiring central venous access. (J Pediatr 1998;133:770-6)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9842042</pmid><doi>10.1016/S0022-3476(98)70149-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Age Distribution Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Canada - epidemiology Catheterization, Central Venous - adverse effects Child Child, Preschool Cohort Studies Emergency and intensive care: techniques, logistics Female Humans Incidence Infant Intensive care medicine Male Medical sciences Perfusions. Catheterizations. Hyperbaric oxygenotherapy Registries Retrospective Studies Venous Thrombosis - epidemiology Venous Thrombosis - etiology |
| title | Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of Venous Thromboembolic Complications |
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