Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study
Purpose The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine. Methods One-hundred and sixteen consecutive patients scheduled for colonoscopy were randomly assigned to groups A or B. Pati...
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| Veröffentlicht in: | Digestive diseases and sciences 2008, Vol.53 (1), p.34-40 |
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| creator | Manolaraki, Maria M. Theodoropoulou, Angeliki Stroumpos, Charalampos Vardas, Emmanouil Oustamanolakis, Pantelis Gritzali, Aliki Chlouverakis, Gregorios Paspatis, Gregorios A. |
| description | Purpose
The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine.
Methods
One-hundred and sixteen consecutive patients scheduled for colonoscopy were randomly assigned to groups A or B. Patients in group A (
n
= 56) received intravenous (IV) midazolam and pethidine. Patients in group B (
n
= 60) received IV remifentanil.
Results
Recovery was faster in group B (0 min) than in group A (56 ± 11.3 min) (
P
|
| doi_str_mv | 10.1007/s10620-007-9818-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70106429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70106429</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-d21a3ecbfa823146618212fbcf79d2294b1bdfd8592129fafe79c31f4161e83c3</originalsourceid><addsrcrecordid>eNp1kV9rFDEUxYModq1-AF8kCPrkaG5mNjPxrax_KlQsrT6HTHJjU2aSMZlRtp--WXZpQehTLuF3Tm7OIeQlsPfAWPshAxOcVWWsZAddxR6RFazbuuJr0T0mKwaizADiiDzL-ZoxJlsQT8kRtE0r1lKsSLzA0TsMsw5-oJs4Tjqhpf_8fEW_e6tv4qBHqoOl5zhfeesD0ku0evYx0E9L8uF3UQ0xxGzitP1IT-h5inlCM_u_-I5eFGkc_U3xvJwXu31Onjg9ZHxxOI_Jry-ff25Oq7MfX79tTs4qU0s5V5aDrtH0Tne8hkYI6Dhw1xvXSsu5bHrorbPdWpZr6bTDVpoaXAMCsKtNfUze7n2nFP8smGc1-mxwGHTAuGTVspJdw2UBX_8HXsclhbKb4tDUXHDOCwR7yJS_5YROTcmPOm0VMLWrQu2rULtxV4ViRfPqYLz0I9p7xSH7Arw5ADobPbikg_H5juOMFaptCsf3XJ52cWO63_Dh128BGsqhSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214326222</pqid></control><display><type>article</type><title>Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Manolaraki, Maria M. ; Theodoropoulou, Angeliki ; Stroumpos, Charalampos ; Vardas, Emmanouil ; Oustamanolakis, Pantelis ; Gritzali, Aliki ; Chlouverakis, Gregorios ; Paspatis, Gregorios A.</creator><creatorcontrib>Manolaraki, Maria M. ; Theodoropoulou, Angeliki ; Stroumpos, Charalampos ; Vardas, Emmanouil ; Oustamanolakis, Pantelis ; Gritzali, Aliki ; Chlouverakis, Gregorios ; Paspatis, Gregorios A.</creatorcontrib><description>Purpose
The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine.
Methods
One-hundred and sixteen consecutive patients scheduled for colonoscopy were randomly assigned to groups A or B. Patients in group A (
n
= 56) received intravenous (IV) midazolam and pethidine. Patients in group B (
n
= 60) received IV remifentanil.
Results
Recovery was faster in group B (0 min) than in group A (56 ± 11.3 min) (
P
< 0.001). There was a marked difference between groups B and A with regard to the time of hospital discharge—28.7 ± 4.3 and 148.9 ± 34 min, respectively (
P
< 0.001). Patients in group A rated the procedure as comfortable, as also did those in group B. A combination of midazolam and pethidine had a greater affect on patients’ cardiorespiratory characteristics.
Conclusion
Remifentanil during colonoscopy provides sufficient pain relief with better hemodynamic stability, less respiratory depression, and significantly faster recovery and hospital discharge than moderate sedation with midazolam and pethidine.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-007-9818-0</identifier><identifier>PMID: 17476596</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Intravenous - therapeutic use ; Biochemistry ; Biological and medical sciences ; Colonic Diseases - diagnosis ; Colonoscopy - methods ; Conscious Sedation - methods ; Digestive system. Abdomen ; Endoscopy ; Female ; Follow-Up Studies ; Gastroenterology ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Hepatology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Midazolam - therapeutic use ; Middle Aged ; Oncology ; Original Paper ; Patient Satisfaction ; Piperidines - therapeutic use ; Prospective Studies ; Transplant Surgery ; Treatment Outcome</subject><ispartof>Digestive diseases and sciences, 2008, Vol.53 (1), p.34-40</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-d21a3ecbfa823146618212fbcf79d2294b1bdfd8592129fafe79c31f4161e83c3</citedby><cites>FETCH-LOGICAL-c399t-d21a3ecbfa823146618212fbcf79d2294b1bdfd8592129fafe79c31f4161e83c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-007-9818-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-007-9818-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20059674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17476596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manolaraki, Maria M.</creatorcontrib><creatorcontrib>Theodoropoulou, Angeliki</creatorcontrib><creatorcontrib>Stroumpos, Charalampos</creatorcontrib><creatorcontrib>Vardas, Emmanouil</creatorcontrib><creatorcontrib>Oustamanolakis, Pantelis</creatorcontrib><creatorcontrib>Gritzali, Aliki</creatorcontrib><creatorcontrib>Chlouverakis, Gregorios</creatorcontrib><creatorcontrib>Paspatis, Gregorios A.</creatorcontrib><title>Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Purpose
The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine.
Methods
One-hundred and sixteen consecutive patients scheduled for colonoscopy were randomly assigned to groups A or B. Patients in group A (
n
= 56) received intravenous (IV) midazolam and pethidine. Patients in group B (
n
= 60) received IV remifentanil.
Results
Recovery was faster in group B (0 min) than in group A (56 ± 11.3 min) (
P
< 0.001). There was a marked difference between groups B and A with regard to the time of hospital discharge—28.7 ± 4.3 and 148.9 ± 34 min, respectively (
P
< 0.001). Patients in group A rated the procedure as comfortable, as also did those in group B. A combination of midazolam and pethidine had a greater affect on patients’ cardiorespiratory characteristics.
Conclusion
Remifentanil during colonoscopy provides sufficient pain relief with better hemodynamic stability, less respiratory depression, and significantly faster recovery and hospital discharge than moderate sedation with midazolam and pethidine.</description><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Colonic Diseases - diagnosis</subject><subject>Colonoscopy - methods</subject><subject>Conscious Sedation - methods</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Midazolam - therapeutic use</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Patient Satisfaction</subject><subject>Piperidines - therapeutic use</subject><subject>Prospective Studies</subject><subject>Transplant Surgery</subject><subject>Treatment Outcome</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV9rFDEUxYModq1-AF8kCPrkaG5mNjPxrax_KlQsrT6HTHJjU2aSMZlRtp--WXZpQehTLuF3Tm7OIeQlsPfAWPshAxOcVWWsZAddxR6RFazbuuJr0T0mKwaizADiiDzL-ZoxJlsQT8kRtE0r1lKsSLzA0TsMsw5-oJs4Tjqhpf_8fEW_e6tv4qBHqoOl5zhfeesD0ku0evYx0E9L8uF3UQ0xxGzitP1IT-h5inlCM_u_-I5eFGkc_U3xvJwXu31Onjg9ZHxxOI_Jry-ff25Oq7MfX79tTs4qU0s5V5aDrtH0Tne8hkYI6Dhw1xvXSsu5bHrorbPdWpZr6bTDVpoaXAMCsKtNfUze7n2nFP8smGc1-mxwGHTAuGTVspJdw2UBX_8HXsclhbKb4tDUXHDOCwR7yJS_5YROTcmPOm0VMLWrQu2rULtxV4ViRfPqYLz0I9p7xSH7Arw5ADobPbikg_H5juOMFaptCsf3XJ52cWO63_Dh128BGsqhSw</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Manolaraki, Maria M.</creator><creator>Theodoropoulou, Angeliki</creator><creator>Stroumpos, Charalampos</creator><creator>Vardas, Emmanouil</creator><creator>Oustamanolakis, Pantelis</creator><creator>Gritzali, Aliki</creator><creator>Chlouverakis, Gregorios</creator><creator>Paspatis, Gregorios A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study</title><author>Manolaraki, Maria M. ; Theodoropoulou, Angeliki ; Stroumpos, Charalampos ; Vardas, Emmanouil ; Oustamanolakis, Pantelis ; Gritzali, Aliki ; Chlouverakis, Gregorios ; Paspatis, Gregorios A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-d21a3ecbfa823146618212fbcf79d2294b1bdfd8592129fafe79c31f4161e83c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Colonic Diseases - diagnosis</topic><topic>Colonoscopy - methods</topic><topic>Conscious Sedation - methods</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Midazolam - therapeutic use</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Patient Satisfaction</topic><topic>Piperidines - therapeutic use</topic><topic>Prospective Studies</topic><topic>Transplant Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manolaraki, Maria M.</creatorcontrib><creatorcontrib>Theodoropoulou, Angeliki</creatorcontrib><creatorcontrib>Stroumpos, Charalampos</creatorcontrib><creatorcontrib>Vardas, Emmanouil</creatorcontrib><creatorcontrib>Oustamanolakis, Pantelis</creatorcontrib><creatorcontrib>Gritzali, Aliki</creatorcontrib><creatorcontrib>Chlouverakis, Gregorios</creatorcontrib><creatorcontrib>Paspatis, Gregorios A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manolaraki, Maria M.</au><au>Theodoropoulou, Angeliki</au><au>Stroumpos, Charalampos</au><au>Vardas, Emmanouil</au><au>Oustamanolakis, Pantelis</au><au>Gritzali, Aliki</au><au>Chlouverakis, Gregorios</au><au>Paspatis, Gregorios A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2008</date><risdate>2008</risdate><volume>53</volume><issue>1</issue><spage>34</spage><epage>40</epage><pages>34-40</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Purpose
The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine.
Methods
One-hundred and sixteen consecutive patients scheduled for colonoscopy were randomly assigned to groups A or B. Patients in group A (
n
= 56) received intravenous (IV) midazolam and pethidine. Patients in group B (
n
= 60) received IV remifentanil.
Results
Recovery was faster in group B (0 min) than in group A (56 ± 11.3 min) (
P
< 0.001). There was a marked difference between groups B and A with regard to the time of hospital discharge—28.7 ± 4.3 and 148.9 ± 34 min, respectively (
P
< 0.001). Patients in group A rated the procedure as comfortable, as also did those in group B. A combination of midazolam and pethidine had a greater affect on patients’ cardiorespiratory characteristics.
Conclusion
Remifentanil during colonoscopy provides sufficient pain relief with better hemodynamic stability, less respiratory depression, and significantly faster recovery and hospital discharge than moderate sedation with midazolam and pethidine.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>17476596</pmid><doi>10.1007/s10620-007-9818-0</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2008, Vol.53 (1), p.34-40 |
| issn | 0163-2116 1573-2568 |
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| subjects | Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Intravenous - therapeutic use Biochemistry Biological and medical sciences Colonic Diseases - diagnosis Colonoscopy - methods Conscious Sedation - methods Digestive system. Abdomen Endoscopy Female Follow-Up Studies Gastroenterology General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Hepatology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Medicine Medicine & Public Health Midazolam - therapeutic use Middle Aged Oncology Original Paper Patient Satisfaction Piperidines - therapeutic use Prospective Studies Transplant Surgery Treatment Outcome |
| title | Remifentanil Compared with Midazolam and Pethidine Sedation During Colonoscopy: A Prospective, Randomized Study |
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