Creatine supplementation improves intracellular Ca2+ handling and survival in mdx skeletal muscle cells

Dystrophic skeletal muscle cells from Duchenne muscular dystrophy (DMD) patients and mdx mice exhibit elevated cytosolic Ca2+ concentrations ([Ca2+]c). Pretreatment of mdx myotubes for 6–12 days with creatine (20 mM) decreased the elevation in [Ca2+]c induced by either high extracellular Ca2+ concen...

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Veröffentlicht in:	FEBS letters 1998-11, Vol.439 (3), p.357-362
Hauptverfasser:	Pulido, S.M, Passaquin, A.C, Leijendekker, W.J, Challet, C, Wallimann, T, Rüegg, U.T
Format:	Artikel
Sprache:	eng
Schlagworte:	[Ca2+]c, cytosolic Ca2+ concentration [Ca2+]extrac, extracellular calcium concentration Adenosine Triphosphate - metabolism Animals Calcium Calcium - metabolism Cell Differentiation - drug effects Cell Survival - drug effects Cells, Cultured CK, creatine kinase Cr, creatine Creatine Creatine - metabolism Creatine - pharmacology DMD, Duchenne muscular dystrophy Duchenne muscular dystrophy EGTA, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid Mdx mouse Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular Dystrophy, Animal - genetics Muscular Dystrophy, Animal - metabolism Osmotic Pressure - drug effects PCr, phosphocreatine PDN, α-methylprednisolone Phosphocreatine - metabolism PSS, physiological salt solution Skeletal muscle SL, sarcolemmal SR, sarcoplasmic Time Factors α-Methylprednisolone
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