Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease
In Parkinson’s disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone.Because no kinematic study has yet investig...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2008-01, Vol.79 (1), p.76-78 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Agostino, R Dinapoli, L Modugno, N Iezzi, E Romanelli, P Berardelli, A |
| description | In Parkinson’s disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone.Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS.We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated.We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson’s disease. |
| doi_str_mv | 10.1136/jnnp.2007.122010 |
| format | Article |
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Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS.We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated.We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson’s disease.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2007.122010</identifier><identifier>PMID: 17682012</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Arm - physiopathology ; Biological and medical sciences ; DBS ; Deep brain stimulation ; Deep Brain Stimulation - instrumentation ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Functional Laterality - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Kinematics ; Male ; Medical sciences ; Middle Aged ; movement studies ; Nervous system (semeiology, syndromes) ; Neurology ; Parkinson Disease - physiopathology ; Parkinson Disease - surgery ; Parkinson's disease ; Patients ; Severity of Illness Index ; Subthalamic Nucleus - physiology</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2008-01, Vol.79 (1), p.76-78</ispartof><rights>2008 BMJ Publishing Group</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b460t-c83bce8076ed85a74f4095e9b9657f159ecf29068ac7bb7a88c5aae270a43b033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/79/1/76.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/79/1/76.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,4010,23550,27900,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19895660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17682012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agostino, R</creatorcontrib><creatorcontrib>Dinapoli, L</creatorcontrib><creatorcontrib>Modugno, N</creatorcontrib><creatorcontrib>Iezzi, E</creatorcontrib><creatorcontrib>Romanelli, P</creatorcontrib><creatorcontrib>Berardelli, A</creatorcontrib><title>Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>In Parkinson’s disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone.Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS.We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated.We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson’s disease.</description><subject>Aged</subject><subject>Arm - physiopathology</subject><subject>Biological and medical sciences</subject><subject>DBS</subject><subject>Deep brain stimulation</subject><subject>Deep Brain Stimulation - instrumentation</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Kinematics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>movement studies</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - surgery</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Severity of Illness Index</subject><subject>Subthalamic Nucleus - physiology</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcuKFDEUhoMoTju6dyUB0Y1Um0vlUsuhnVFh8AKjDm7CSTqFaatSbVIlihtfw9fzSUxZjQNuJgRyQr7_z0l-hO5TsqaUy6e7GPdrRohaU8YIJTfQitZSV5yTy5toRQhjFSeCHKE7Oe_IPHRzGx1RJXXh2Qr9OG1b78aMhxZPMXQw-gQdzpMdP0EHfXB46_0e2wQh4jyGfipMGCIu0w1xLPRBA6nH2X-ZfBxD2fbDV9-XOuMifAPpc4h5iL9__sp4G7KH7O-iWy102d87rMfo3dnpxeZFdf76-cvNyXlla0nGymlunddESb_VAlTd1qQRvrGNFKqlovGuZQ2RGpyyVoHWTgB4pgjU3BLOj9HjxXefhtJeHk0fsvNdB9EPUzaq_JyotboWpE0ta6Zm8OF_4G6YUiyPMFRpymqm_95LFsqlIefkW7NPoYf03VBi5vzMnJ-Z8zNLfkXy4GA82d5vrwSHwArw6ABAdtC1CaIL-YprdCOknI2qhQt59N_-nZcYjFRcCfPq_cZ8PHv77AO_uDSi8E8W3va769v8AwAGwxg</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Agostino, R</creator><creator>Dinapoli, L</creator><creator>Modugno, N</creator><creator>Iezzi, E</creator><creator>Romanelli, P</creator><creator>Berardelli, A</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease</title><author>Agostino, R ; Dinapoli, L ; Modugno, N ; Iezzi, E ; Romanelli, P ; Berardelli, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b460t-c83bce8076ed85a74f4095e9b9657f159ecf29068ac7bb7a88c5aae270a43b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Arm - physiopathology</topic><topic>Biological and medical sciences</topic><topic>DBS</topic><topic>Deep brain stimulation</topic><topic>Deep Brain Stimulation - instrumentation</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Kinematics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>movement studies</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - surgery</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Severity of Illness Index</topic><topic>Subthalamic Nucleus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agostino, R</creatorcontrib><creatorcontrib>Dinapoli, L</creatorcontrib><creatorcontrib>Modugno, N</creatorcontrib><creatorcontrib>Iezzi, E</creatorcontrib><creatorcontrib>Romanelli, P</creatorcontrib><creatorcontrib>Berardelli, A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agostino, R</au><au>Dinapoli, L</au><au>Modugno, N</au><au>Iezzi, E</au><au>Romanelli, P</au><au>Berardelli, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2008-01</date><risdate>2008</risdate><volume>79</volume><issue>1</issue><spage>76</spage><epage>78</epage><pages>76-78</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>In Parkinson’s disease, unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN), unlike bilateral stimulation, excludes ipsilateral confounding effects so that the contralateral effects of DBS on motor performance can be investigated alone.Because no kinematic study has yet investigated how unilateral STN-DBS affects the performance of a contralateral fast sequential motor act, we performed a kinematic analysis of the movement duration, switching time and spatial accuracy of a motor arm sequence in 10 parkinsonian patients. Patients were studied without dopaminergic therapy and when they were OFF and ON unilateral STN-DBS.We found that unilateral STN-DBS significantly improved movement time of a motor sequence and the switching time from one sequential step to the next, whereas accuracy deteriorated.We conclude that unilateral STN-DBS improves the performance of contralateral sequential arm movements in patients with Parkinson’s disease.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>17682012</pmid><doi>10.1136/jnnp.2007.122010</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Arm - physiopathology Biological and medical sciences DBS Deep brain stimulation Deep Brain Stimulation - instrumentation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Functional Laterality - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Kinematics Male Medical sciences Middle Aged movement studies Nervous system (semeiology, syndromes) Neurology Parkinson Disease - physiopathology Parkinson Disease - surgery Parkinson's disease Patients Severity of Illness Index Subthalamic Nucleus - physiology |
| title | Effects of unilateral subthalamic deep brain stimulation on contralateral arm sequential movements in Parkinson’s disease |
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