Role of BMP-4 during tooth development in a model with complete dentition
Abstract There are no reports in literature about roles of bone morphogenetic protein 4 (BMP-4) in tooth development in mammals with complete dentition (with all dental groups). The classical model of study is the mouse, which has distinctive incisor and molar patterns. The opossum Didelphis albiven...
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| Veröffentlicht in: | Archives of oral biology 2008-01, Vol.53 (1), p.2-8 |
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| container_title | Archives of oral biology |
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| creator | Torres, C.B.B Alves, J.B Silva, G.A.B Goes, V.S Nakao, L.Y.S Goes, A.M |
| description | Abstract There are no reports in literature about roles of bone morphogenetic protein 4 (BMP-4) in tooth development in mammals with complete dentition (with all dental groups). The classical model of study is the mouse, which has distinctive incisor and molar patterns. The opossum Didelphis albiventris with five upper and four lower incisors, one canine, three premolars and four molars, on each side of the jaw, seems to be a convenient model for odontogenesis study. This investigation searched for similarities and differences in BMP-4 expression pattern between the opossum and the mouse. BMP-4 cDNA was obtained by RT-PCR and the expression pattern during molar tooth development was investigated by the immunoperoxidase method. Opossum BMP-4 mature protein has 95% of sequence similarity in relation to mouse and 94% to human. The BMP-4 expression pattern during opossum tooth development was suggestive of a role in dental organ initiation and morphogenesis. |
| doi_str_mv | 10.1016/j.archoralbio.2007.07.005 |
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The classical model of study is the mouse, which has distinctive incisor and molar patterns. The opossum Didelphis albiventris with five upper and four lower incisors, one canine, three premolars and four molars, on each side of the jaw, seems to be a convenient model for odontogenesis study. This investigation searched for similarities and differences in BMP-4 expression pattern between the opossum and the mouse. BMP-4 cDNA was obtained by RT-PCR and the expression pattern during molar tooth development was investigated by the immunoperoxidase method. Opossum BMP-4 mature protein has 95% of sequence similarity in relation to mouse and 94% to human. The BMP-4 expression pattern during opossum tooth development was suggestive of a role in dental organ initiation and morphogenesis.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2007.07.005</identifier><identifier>PMID: 17803954</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Amino Acid Sequence ; Animals ; Base Sequence ; BMP-4 ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins - analysis ; Bone Morphogenetic Proteins - genetics ; Bone Morphogenetic Proteins - physiology ; Cloning ; Dentistry ; Dentition ; Didelphis - growth & development ; Didelphis - physiology ; Didelphis albiventris ; DNA, Complementary - analysis ; Expression pattern ; Gene Expression Regulation, Developmental ; Humans ; Immunoenzyme Techniques ; Mice ; Models, Animal ; Molar ; Molecular Sequence Data ; Odontogenesis - physiology ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Sequence Analysis, DNA ; Sequence Homology ; Tooth development</subject><ispartof>Archives of oral biology, 2008-01, Vol.53 (1), p.2-8</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-9dc1aa08af554b5869b0941c3b1a95fda06bd33107e78cb780bc8bfe2bea125e3</citedby><cites>FETCH-LOGICAL-c430t-9dc1aa08af554b5869b0941c3b1a95fda06bd33107e78cb780bc8bfe2bea125e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2007.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17803954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torres, C.B.B</creatorcontrib><creatorcontrib>Alves, J.B</creatorcontrib><creatorcontrib>Silva, G.A.B</creatorcontrib><creatorcontrib>Goes, V.S</creatorcontrib><creatorcontrib>Nakao, L.Y.S</creatorcontrib><creatorcontrib>Goes, A.M</creatorcontrib><title>Role of BMP-4 during tooth development in a model with complete dentition</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract There are no reports in literature about roles of bone morphogenetic protein 4 (BMP-4) in tooth development in mammals with complete dentition (with all dental groups). The classical model of study is the mouse, which has distinctive incisor and molar patterns. The opossum Didelphis albiventris with five upper and four lower incisors, one canine, three premolars and four molars, on each side of the jaw, seems to be a convenient model for odontogenesis study. This investigation searched for similarities and differences in BMP-4 expression pattern between the opossum and the mouse. BMP-4 cDNA was obtained by RT-PCR and the expression pattern during molar tooth development was investigated by the immunoperoxidase method. Opossum BMP-4 mature protein has 95% of sequence similarity in relation to mouse and 94% to human. The BMP-4 expression pattern during opossum tooth development was suggestive of a role in dental organ initiation and morphogenesis.</description><subject>Advanced Basic Science</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>BMP-4</subject><subject>Bone Morphogenetic Protein 4</subject><subject>Bone Morphogenetic Proteins - analysis</subject><subject>Bone Morphogenetic Proteins - genetics</subject><subject>Bone Morphogenetic Proteins - physiology</subject><subject>Cloning</subject><subject>Dentistry</subject><subject>Dentition</subject><subject>Didelphis - growth & development</subject><subject>Didelphis - physiology</subject><subject>Didelphis albiventris</subject><subject>DNA, Complementary - analysis</subject><subject>Expression pattern</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>Molar</subject><subject>Molecular Sequence Data</subject><subject>Odontogenesis - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>Tooth development</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVuL1DAUgIMo7rj6FyS--NbxpG3a5kXQwcvCyi6rPockPXUzpsmYpLvsvzdlBhSfhAMh5DuXfIeQVwy2DFj3Zr9V0dyGqJy2YVsD9Ns1gD8iGzb0omIcusdkAwBNJUQnzsizlPblyruOPSVnrB-gEbzdkIub4JCGib7_cl21dFyi9T9oDiHf0hHv0IXDjD5T66micxjR0Xtb3kyYDw4zFshnm23wz8mTSbmEL07nOfn-8cO33efq8urTxe7dZWXaBnIlRsOUgkFNnLeaD53QIFpmGs2U4NOooNNj0zDosR-MLoNqM-gJa42K1Rybc_L6WPcQw68FU5azTQadUx7DkmQPqyPOCiiOoIkhpYiTPEQ7q_ggGciVkXv5l0e5epRrAC-5L09NFj3j-CfzJK4AuyOA5at3FqNMxqI3ONqIJssx2P9q8_afKsZZb41yP_EB0z4s0ReXkslUS5Bf14Wu-4QegPU1NL8BhF-e0g</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Torres, C.B.B</creator><creator>Alves, J.B</creator><creator>Silva, G.A.B</creator><creator>Goes, V.S</creator><creator>Nakao, L.Y.S</creator><creator>Goes, A.M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Role of BMP-4 during tooth development in a model with complete dentition</title><author>Torres, C.B.B ; Alves, J.B ; Silva, G.A.B ; Goes, V.S ; Nakao, L.Y.S ; Goes, A.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-9dc1aa08af554b5869b0941c3b1a95fda06bd33107e78cb780bc8bfe2bea125e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Advanced Basic Science</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>BMP-4</topic><topic>Bone Morphogenetic Protein 4</topic><topic>Bone Morphogenetic Proteins - analysis</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - physiology</topic><topic>Cloning</topic><topic>Dentistry</topic><topic>Dentition</topic><topic>Didelphis - growth & development</topic><topic>Didelphis - physiology</topic><topic>Didelphis albiventris</topic><topic>DNA, Complementary - analysis</topic><topic>Expression pattern</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Mice</topic><topic>Models, Animal</topic><topic>Molar</topic><topic>Molecular Sequence Data</topic><topic>Odontogenesis - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology</topic><topic>Tooth development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torres, C.B.B</creatorcontrib><creatorcontrib>Alves, J.B</creatorcontrib><creatorcontrib>Silva, G.A.B</creatorcontrib><creatorcontrib>Goes, V.S</creatorcontrib><creatorcontrib>Nakao, L.Y.S</creatorcontrib><creatorcontrib>Goes, A.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torres, C.B.B</au><au>Alves, J.B</au><au>Silva, G.A.B</au><au>Goes, V.S</au><au>Nakao, L.Y.S</au><au>Goes, A.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of BMP-4 during tooth development in a model with complete dentition</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>53</volume><issue>1</issue><spage>2</spage><epage>8</epage><pages>2-8</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract There are no reports in literature about roles of bone morphogenetic protein 4 (BMP-4) in tooth development in mammals with complete dentition (with all dental groups). The classical model of study is the mouse, which has distinctive incisor and molar patterns. The opossum Didelphis albiventris with five upper and four lower incisors, one canine, three premolars and four molars, on each side of the jaw, seems to be a convenient model for odontogenesis study. This investigation searched for similarities and differences in BMP-4 expression pattern between the opossum and the mouse. BMP-4 cDNA was obtained by RT-PCR and the expression pattern during molar tooth development was investigated by the immunoperoxidase method. Opossum BMP-4 mature protein has 95% of sequence similarity in relation to mouse and 94% to human. The BMP-4 expression pattern during opossum tooth development was suggestive of a role in dental organ initiation and morphogenesis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17803954</pmid><doi>10.1016/j.archoralbio.2007.07.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Advanced Basic Science Amino Acid Sequence Animals Base Sequence BMP-4 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - analysis Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - physiology Cloning Dentistry Dentition Didelphis - growth & development Didelphis - physiology Didelphis albiventris DNA, Complementary - analysis Expression pattern Gene Expression Regulation, Developmental Humans Immunoenzyme Techniques Mice Models, Animal Molar Molecular Sequence Data Odontogenesis - physiology Reverse Transcriptase Polymerase Chain Reaction - methods Sequence Analysis, DNA Sequence Homology Tooth development |
| title | Role of BMP-4 during tooth development in a model with complete dentition |
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