NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors

Abstract NK314 is a novel synthetic benzo[ c ]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1 h after treatment with NK314 even without digestion of topoisom...

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Veröffentlicht in:	Cancer letters 2008-01, Vol.259 (1), p.99-110
Hauptverfasser:	Onda, Takeshi, Toyoda, Eriko, Miyazaki, Osamu, Seno, Chieko, Kagaya, Shigehide, Okamoto, Kazuya, Nishikawa, Kiyohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Cancer therapies Cell cycle Cell Proliferation - drug effects Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA double-strand breaks DNA repair DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Drug Resistance, Neoplasm Endopeptidase K - metabolism Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Etoposide Female Gastric cancer Hematology, Oncology and Palliative Medicine HL-60 Cells Humans Leukemia Leukemia P388 Mice Mice, Inbred BALB C Mice, Nude Molecular weight Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics NK314 Phenanthrenes - pharmacology Phenanthrenes - therapeutic use Time Factors Topoisomerase II Topoisomerase II Inhibitors Tumors Xenograft Model Antitumor Assays
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