Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding

Abstract The RNA polymerase of influenza A virus is a heterotrimeric complex of PB1, PB2 and PA subunits that is required for transcription and replication of the viral genome. Here, we demonstrate a differential requirement of the PA subunit for binding to the vRNA and cRNA promoters — specifically...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-01, Vol.370 (1), p.194-204
Hauptverfasser:	Maier, Helena J, Kashiwagi, Takahito, Hara, Koyu, Brownlee, George G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - metabolism Humans Infectious Disease Influenza Influenza A virus Influenza A virus - enzymology Influenza A virus - metabolism PA subunit Point Mutation Promoter Regions, Genetic - physiology Replication RNA polymerase RNA Replicase - chemistry RNA Replicase - genetics RNA Replicase - metabolism RNA, Complementary - metabolism RNA, Viral - metabolism Transcription, Genetic Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virus Replication vRNA cRNA promoter binding
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