Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy

Cardiomyocyte hypertrophy differs according to the stress exerted on the myocardium. While pressure overload‐induced cardiomyocyte hypertrophy is associated with depressed contractile function, physiological hypertrophy after exercise training associates with preserved or increased inotropy. We dete...

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Veröffentlicht in:	Journal of cellular physiology 2008-02, Vol.214 (2), p.316-321
Hauptverfasser:	Kemi, Ole Johan, Ceci, Marcello, Wisloff, Ulrik, Grimaldi, Serena, Gallo, Paolo, Smith, Godfrey L, Condorelli, Gianluigi, Ellingsen, Oyvind
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - physiopathology Cardiomegaly - physiopathology Carrier Proteins - metabolism Cell Size Constriction, Pathologic - physiopathology Echocardiography Enzyme Activation - drug effects Exercise Test Female Heart Ventricles - cytology Hypertrophy - physiopathology Mice Mice, Inbred C57BL Models, Biological Myocardium - metabolism Myocytes, Cardiac - pathology Phosphoproteins - metabolism Phosphorylation - drug effects Physical Conditioning, Animal Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Random Allocation Ribosomal Protein S6 Kinases - metabolism Serine - metabolism Signal Transduction Sirolimus - pharmacology Time Factors TOR Serine-Threonine Kinases
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