Two New Members of Streptothricin Class Antibiotics from Streptomyces qinlingensis sp. nov
Four streptothricin-group antibiotics ( 1 ~ 4 ) were isolated from the fermentation broth of Streptomyces qinlingensis sp. nov. Along with the known antibiotics streptothricins F ( 1 ) and D ( 3 ), two new members of this class ( 2 , 4 ) were identified as 12-carbamoyl derivatives of 1 and 3 , respe...
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| Veröffentlicht in: | Journal of antibiotics 2007-12, Vol.60 (12), p.739-744 |
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| creator | Ji, Zhiqin Wang, Mingan Zhang, Jiwen Wei, Shaopeng Wu, Wenjun |
| description | Four streptothricin-group antibiotics (
1
~
4
) were isolated from the fermentation broth of
Streptomyces qinlingensis
sp. nov. Along with the known antibiotics streptothricins F (
1
) and D (
3
), two new members of this class (
2
,
4
) were identified as 12-carbamoyl derivatives of
1
and
3
, respectively, mainly by analysis of the IR, HR-MS and NMR spectral data. The antibacterial activities of
1
~
4
against
Escherichia coli
(MICs 3.1, 25.0, 3.1 and 12.5 μg/ml),
Bacillus subtilis
(MICs 6.3, 25.0, 3.1 and 50 μg/ml),
Staphylococcus aureus
(MICs 12.5, >100.0, 6.3, >100.0 μg/ml),
Bacillus cereus
(MICs 25.0, 50.0, 25.0 and 50.0 μg/ml) and
Pseudomonas aeruginosa
(MICs 50.0, >100.0, 50.0, >100.0 μg/ml) were assayed by micro-broth dilution. The results based on MIC data indicated that
2
and
4
exhibited significantly less potent antibacterial activities when compared to that of
1
and
3
. |
| doi_str_mv | 10.1038/ja.2007.96 |
| format | Article |
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1
~
4
) were isolated from the fermentation broth of
Streptomyces qinlingensis
sp. nov. Along with the known antibiotics streptothricins F (
1
) and D (
3
), two new members of this class (
2
,
4
) were identified as 12-carbamoyl derivatives of
1
and
3
, respectively, mainly by analysis of the IR, HR-MS and NMR spectral data. The antibacterial activities of
1
~
4
against
Escherichia coli
(MICs 3.1, 25.0, 3.1 and 12.5 μg/ml),
Bacillus subtilis
(MICs 6.3, 25.0, 3.1 and 50 μg/ml),
Staphylococcus aureus
(MICs 12.5, >100.0, 6.3, >100.0 μg/ml),
Bacillus cereus
(MICs 25.0, 50.0, 25.0 and 50.0 μg/ml) and
Pseudomonas aeruginosa
(MICs 50.0, >100.0, 50.0, >100.0 μg/ml) were assayed by micro-broth dilution. The results based on MIC data indicated that
2
and
4
exhibited significantly less potent antibacterial activities when compared to that of
1
and
3
.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2007.96</identifier><identifier>PMID: 18276997</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacillus cereus ; Bacillus cereus - drug effects ; Bacillus subtilis ; Bacillus subtilis - drug effects ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Chromatography, Liquid ; E coli ; Escherichia coli ; Escherichia coli - drug effects ; Fermentation ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; Life Sciences ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology ; Organic Chemistry ; original-article ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Spectrophotometry, Infrared ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Streptomyces ; Streptomyces - metabolism ; Streptothricins - chemistry ; Streptothricins - isolation & purification ; Streptothricins - pharmacology</subject><ispartof>Journal of antibiotics, 2007-12, Vol.60 (12), p.739-744</ispartof><rights>Japan Antibiotics Research Association 2007</rights><rights>Copyright Nature Publishing Group Dec 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-aeaed6c3b18a7ba5ec09f17f682ffc9ef3d32519f5a0a6f88dee07208ffe98283</citedby><cites>FETCH-LOGICAL-c511t-aeaed6c3b18a7ba5ec09f17f682ffc9ef3d32519f5a0a6f88dee07208ffe98283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18276997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Zhiqin</creatorcontrib><creatorcontrib>Wang, Mingan</creatorcontrib><creatorcontrib>Zhang, Jiwen</creatorcontrib><creatorcontrib>Wei, Shaopeng</creatorcontrib><creatorcontrib>Wu, Wenjun</creatorcontrib><title>Two New Members of Streptothricin Class Antibiotics from Streptomyces qinlingensis sp. nov</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Four streptothricin-group antibiotics (
1
~
4
) were isolated from the fermentation broth of
Streptomyces qinlingensis
sp. nov. Along with the known antibiotics streptothricins F (
1
) and D (
3
), two new members of this class (
2
,
4
) were identified as 12-carbamoyl derivatives of
1
and
3
, respectively, mainly by analysis of the IR, HR-MS and NMR spectral data. The antibacterial activities of
1
~
4
against
Escherichia coli
(MICs 3.1, 25.0, 3.1 and 12.5 μg/ml),
Bacillus subtilis
(MICs 6.3, 25.0, 3.1 and 50 μg/ml),
Staphylococcus aureus
(MICs 12.5, >100.0, 6.3, >100.0 μg/ml),
Bacillus cereus
(MICs 25.0, 50.0, 25.0 and 50.0 μg/ml) and
Pseudomonas aeruginosa
(MICs 50.0, >100.0, 50.0, >100.0 μg/ml) were assayed by micro-broth dilution. The results based on MIC data indicated that
2
and
4
exhibited significantly less potent antibacterial activities when compared to that of
1
and
3
.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacillus cereus</subject><subject>Bacillus cereus - drug effects</subject><subject>Bacillus subtilis</subject><subject>Bacillus subtilis - drug effects</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Chromatography, Liquid</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Fermentation</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Spectrophotometry, Infrared</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Streptomyces</subject><subject>Streptomyces - metabolism</subject><subject>Streptothricins - chemistry</subject><subject>Streptothricins - isolation & purification</subject><subject>Streptothricins - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0U1P3DAQBmALUZWF9tIfgCwhcQBlO3ZIbB9XK2gr8XEovfRiOd5x8SqJF08WxL8naLeiKgdOPsyjdzR-GfsiYCqg1F-XbioB1NTUO2witBaFOKvNLpsASFFoLWGP7RMtAUpVKv2R7QktVW2MmrDft4-JX-Mjv8KuwUw8Bf5zyLga0nCXo489n7eOiM_6ITYxDdETDzl1f1X35JH4fezb2P_BniJxWk15nx4-sQ_BtYSft-8B-3Vxfjv_XlzefPsxn10WvhJiKBw6XNS-bIR2qnEVejBBqFBrGYI3GMpFKSthQuXA1UHrBSIoCToENFrq8oAdb3JXOd2vkQbbRfLYtq7HtCarAEx9Jqt3oRydqIwc4dF_cJnWuR-PsEJppaEyBkZ1slE-J6KMwa5y7Fx-sgLsSzF26exLMdbUIz7cRq6bDhevdNvECE43gMbR-JP5n51v454B1ySXyg</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Ji, Zhiqin</creator><creator>Wang, Mingan</creator><creator>Zhang, Jiwen</creator><creator>Wei, Shaopeng</creator><creator>Wu, Wenjun</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Two New Members of Streptothricin Class Antibiotics from Streptomyces qinlingensis sp. nov</title><author>Ji, Zhiqin ; Wang, Mingan ; Zhang, Jiwen ; Wei, Shaopeng ; Wu, Wenjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-aeaed6c3b18a7ba5ec09f17f682ffc9ef3d32519f5a0a6f88dee07208ffe98283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacillus cereus</topic><topic>Bacillus cereus - drug effects</topic><topic>Bacillus subtilis</topic><topic>Bacillus subtilis - drug effects</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Chromatography, Liquid</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Fermentation</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Spectrophotometry, Infrared</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Streptomyces</topic><topic>Streptomyces - metabolism</topic><topic>Streptothricins - chemistry</topic><topic>Streptothricins - isolation & purification</topic><topic>Streptothricins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Zhiqin</creatorcontrib><creatorcontrib>Wang, Mingan</creatorcontrib><creatorcontrib>Zhang, Jiwen</creatorcontrib><creatorcontrib>Wei, Shaopeng</creatorcontrib><creatorcontrib>Wu, Wenjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Zhiqin</au><au>Wang, Mingan</au><au>Zhang, Jiwen</au><au>Wei, Shaopeng</au><au>Wu, Wenjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two New Members of Streptothricin Class Antibiotics from Streptomyces qinlingensis sp. nov</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>60</volume><issue>12</issue><spage>739</spage><epage>744</epage><pages>739-744</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Four streptothricin-group antibiotics (
1
~
4
) were isolated from the fermentation broth of
Streptomyces qinlingensis
sp. nov. Along with the known antibiotics streptothricins F (
1
) and D (
3
), two new members of this class (
2
,
4
) were identified as 12-carbamoyl derivatives of
1
and
3
, respectively, mainly by analysis of the IR, HR-MS and NMR spectral data. The antibacterial activities of
1
~
4
against
Escherichia coli
(MICs 3.1, 25.0, 3.1 and 12.5 μg/ml),
Bacillus subtilis
(MICs 6.3, 25.0, 3.1 and 50 μg/ml),
Staphylococcus aureus
(MICs 12.5, >100.0, 6.3, >100.0 μg/ml),
Bacillus cereus
(MICs 25.0, 50.0, 25.0 and 50.0 μg/ml) and
Pseudomonas aeruginosa
(MICs 50.0, >100.0, 50.0, >100.0 μg/ml) were assayed by micro-broth dilution. The results based on MIC data indicated that
2
and
4
exhibited significantly less potent antibacterial activities when compared to that of
1
and
3
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18276997</pmid><doi>10.1038/ja.2007.96</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2007-12, Vol.60 (12), p.739-744 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70096425 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics Bacillus cereus Bacillus cereus - drug effects Bacillus subtilis Bacillus subtilis - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Chromatography, Liquid E coli Escherichia coli Escherichia coli - drug effects Fermentation Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Life Sciences Magnetic Resonance Spectroscopy Mass Spectrometry Medicinal Chemistry Microbial Sensitivity Tests Microbiology Organic Chemistry original-article Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Spectrophotometry, Infrared Staphylococcus aureus Staphylococcus aureus - drug effects Streptomyces Streptomyces - metabolism Streptothricins - chemistry Streptothricins - isolation & purification Streptothricins - pharmacology |
| title | Two New Members of Streptothricin Class Antibiotics from Streptomyces qinlingensis sp. nov |
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