Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase

Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes...

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Veröffentlicht in:	Journal of neuroscience research 1998-12, Vol.54 (5), p.691-697
Hauptverfasser:	Xu, Yimei, Stokes, Alan H., Roskoski Jr, Robert, Vrana, Kent E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Chromatography, Gel Dihydroxyphenylalanine - pharmacology Dithiothreitol - pharmacology dopamine Dopamine - analogs & derivatives Dopamine - metabolism Dopamine - pharmacology Electrophoresis, Polyacrylamide Gel Feedback Glutathione - pharmacology Monophenol Monooxygenase - metabolism NAD - pharmacology Neoplasm Proteins - metabolism Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Parkinson Disease - metabolism Parkinson's disease PC12 Cells - enzymology Plant Proteins - metabolism Precipitin Tests quinone Rats tyrosinase Tyrosine 3-Monooxygenase - antagonists & inhibitors Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase
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