Molecular modeling of the oxidized form of nuclear factor-κB suggests a mechanism for redox regulation of DNA binding and transcriptional activation

NF-κB is an important transcriptional regulator of numerous cellular genes, as well as viruses such as HIV-1. Oxidative stimuli in the cytosol are associated with nuclear translocation of NF-κB, whereas in the nucleus, reductive activation by thioredoxin is required for NF-κB to bind to DNA and acti...

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