Adult Stem Cell Therapy of Female Stress Urinary Incontinence
Abstract Objectives To investigate the efficacy of transurethral ultrasound (TUUS)-guided injections of autologous myoblasts and fibroblasts in women with incontinence. Methods Between January and June 2005, 20 female patients suffering from stress urinary incontinence (SUI) were included. Skeletal...
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| Veröffentlicht in: | European urology 2008-01, Vol.53 (1), p.169-175 |
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| creator | Mitterberger, Michael Pinggera, Germar-Michael Marksteiner, Rainer Margreiter, Eva Fussenegger, Martin Frauscher, Ferdinand Ulmer, Hanno Hering, Steffen Bartsch, Georg Strasser, Hannes |
| description | Abstract Objectives To investigate the efficacy of transurethral ultrasound (TUUS)-guided injections of autologous myoblasts and fibroblasts in women with incontinence. Methods Between January and June 2005, 20 female patients suffering from stress urinary incontinence (SUI) were included. Skeletal muscle biopsies were taken from the left arm to obtain cultures from autologous fibroblasts and myoblasts. By TUUS guidance the fibroblasts were injected into the urethral submucosa and the myoblasts were injected into the rhabdosphincter. A defined incontinence score, quality-of-life score and urodynamic, electromyographic, and laboratory parameters, as well as morphology and function of urethra and rhabdosphincter were evaluated before and up to 2 yr after therapy. Results Eigtheen of 20 patients were cured 1 yr after injection of autologous stem cells and in 2 patients SUI was improved. Two years after therapy 16 of the 18 patients presented as cured, 2 others were improved, and 2 were lost to follow-up. Incontinence and quality-of-life scores were significantly improved postoperatively. The thickness of urethra and rhabdosphincter as well as activity and contractility of the rhabdosphincter were also statistically significantly increased after therapy. Conclusions Clinical results demonstrate that SUI can be treated effectively with autologous stem cells. The present data support the conclusion that this therapeutic concept represents an elegant and minimally invasive treatment modality to treat SUI. |
| doi_str_mv | 10.1016/j.eururo.2007.07.026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70094407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0302283807009359</els_id><sourcerecordid>19372445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-b2e409b1ae882f7fbd19474ee8d976cb6d15a50df2ee8d377d6969b35d21e6943</originalsourceid><addsrcrecordid>eNqFks9rFDEUgIModlv9D0TmordZ8zuTg0JZbC0UPLQ9h0zyBrPOZNZkRtj_3oRdKHgpBAIv33t5-fIQ-kDwlmAiv-y3sKY1zVuKsdrWReUrtCGdYq0SEr9GG8wwbWnHugt0mfMeY8yEZm_RBVGyRAXdoK_Xfh2X5mGBqdnBODaPvyDZw7GZh-YGJjtCOUuQc_OUQrTp2NxFN8clRIgO3qE3gx0zvD_vV-jp5vvj7kd7__P2bnd93zrB6dL2FDjWPbHQdXRQQ--J5ooDdF4r6XrpibAC-4HWEFPKSy11z4SnBKTm7Ap9PtU9pPnPCnkxU8iutGsjzGs2CmPNOVYvgkQzRTkXBeQn0KU55wSDOaQwlfcZgk31a_bm5NdUv6YuKkvax3P9tZ_APyedhRbg0xmw2dlxSDa6kJ853WkhWVe4bycOira_AZLJLlSlPiRwi_FzeKmT_wu4McRQ7vwNR8j7eU2xfIkhJlODzUOdhToKuLqqY_APc5ausQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19372445</pqid></control><display><type>article</type><title>Adult Stem Cell Therapy of Female Stress Urinary Incontinence</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mitterberger, Michael ; Pinggera, Germar-Michael ; Marksteiner, Rainer ; Margreiter, Eva ; Fussenegger, Martin ; Frauscher, Ferdinand ; Ulmer, Hanno ; Hering, Steffen ; Bartsch, Georg ; Strasser, Hannes</creator><creatorcontrib>Mitterberger, Michael ; Pinggera, Germar-Michael ; Marksteiner, Rainer ; Margreiter, Eva ; Fussenegger, Martin ; Frauscher, Ferdinand ; Ulmer, Hanno ; Hering, Steffen ; Bartsch, Georg ; Strasser, Hannes</creatorcontrib><description>Abstract Objectives To investigate the efficacy of transurethral ultrasound (TUUS)-guided injections of autologous myoblasts and fibroblasts in women with incontinence. Methods Between January and June 2005, 20 female patients suffering from stress urinary incontinence (SUI) were included. Skeletal muscle biopsies were taken from the left arm to obtain cultures from autologous fibroblasts and myoblasts. By TUUS guidance the fibroblasts were injected into the urethral submucosa and the myoblasts were injected into the rhabdosphincter. A defined incontinence score, quality-of-life score and urodynamic, electromyographic, and laboratory parameters, as well as morphology and function of urethra and rhabdosphincter were evaluated before and up to 2 yr after therapy. Results Eigtheen of 20 patients were cured 1 yr after injection of autologous stem cells and in 2 patients SUI was improved. Two years after therapy 16 of the 18 patients presented as cured, 2 others were improved, and 2 were lost to follow-up. Incontinence and quality-of-life scores were significantly improved postoperatively. The thickness of urethra and rhabdosphincter as well as activity and contractility of the rhabdosphincter were also statistically significantly increased after therapy. Conclusions Clinical results demonstrate that SUI can be treated effectively with autologous stem cells. The present data support the conclusion that this therapeutic concept represents an elegant and minimally invasive treatment modality to treat SUI.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>DOI: 10.1016/j.eururo.2007.07.026</identifier><identifier>PMID: 17683852</identifier><identifier>CODEN: EUURAV</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Biological and medical sciences ; Biopsy ; Cells, Cultured ; Electromyography ; Endosonography ; Female ; Fibroblasts - cytology ; Fibroblasts - transplantation ; Follow-Up Studies ; Humans ; Incontinence ; Injections ; Medical sciences ; Middle Aged ; Myoblasts ; Myoblasts, Skeletal - cytology ; Myoblasts, Skeletal - transplantation ; Nephrology. Urinary tract diseases ; Quality of Life ; Rhabdosphincter ; Stem Cell Transplantation - methods ; Stem cells ; Transplantation, Autologous ; Transurethral ultrasound ; Treatment Outcome ; Urethra ; Urinary Bladder ; Urinary Incontinence, Stress - diagnostic imaging ; Urinary Incontinence, Stress - physiopathology ; Urinary Incontinence, Stress - surgery ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Urodynamics ; Urology</subject><ispartof>European urology, 2008-01, Vol.53 (1), p.169-175</ispartof><rights>European Association of Urology</rights><rights>2007 European Association of Urology</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-b2e409b1ae882f7fbd19474ee8d976cb6d15a50df2ee8d377d6969b35d21e6943</citedby><cites>FETCH-LOGICAL-c542t-b2e409b1ae882f7fbd19474ee8d976cb6d15a50df2ee8d377d6969b35d21e6943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0302283807009359$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19895638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17683852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitterberger, Michael</creatorcontrib><creatorcontrib>Pinggera, Germar-Michael</creatorcontrib><creatorcontrib>Marksteiner, Rainer</creatorcontrib><creatorcontrib>Margreiter, Eva</creatorcontrib><creatorcontrib>Fussenegger, Martin</creatorcontrib><creatorcontrib>Frauscher, Ferdinand</creatorcontrib><creatorcontrib>Ulmer, Hanno</creatorcontrib><creatorcontrib>Hering, Steffen</creatorcontrib><creatorcontrib>Bartsch, Georg</creatorcontrib><creatorcontrib>Strasser, Hannes</creatorcontrib><title>Adult Stem Cell Therapy of Female Stress Urinary Incontinence</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>Abstract Objectives To investigate the efficacy of transurethral ultrasound (TUUS)-guided injections of autologous myoblasts and fibroblasts in women with incontinence. Methods Between January and June 2005, 20 female patients suffering from stress urinary incontinence (SUI) were included. Skeletal muscle biopsies were taken from the left arm to obtain cultures from autologous fibroblasts and myoblasts. By TUUS guidance the fibroblasts were injected into the urethral submucosa and the myoblasts were injected into the rhabdosphincter. A defined incontinence score, quality-of-life score and urodynamic, electromyographic, and laboratory parameters, as well as morphology and function of urethra and rhabdosphincter were evaluated before and up to 2 yr after therapy. Results Eigtheen of 20 patients were cured 1 yr after injection of autologous stem cells and in 2 patients SUI was improved. Two years after therapy 16 of the 18 patients presented as cured, 2 others were improved, and 2 were lost to follow-up. Incontinence and quality-of-life scores were significantly improved postoperatively. The thickness of urethra and rhabdosphincter as well as activity and contractility of the rhabdosphincter were also statistically significantly increased after therapy. Conclusions Clinical results demonstrate that SUI can be treated effectively with autologous stem cells. The present data support the conclusion that this therapeutic concept represents an elegant and minimally invasive treatment modality to treat SUI.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cells, Cultured</subject><subject>Electromyography</subject><subject>Endosonography</subject><subject>Female</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - transplantation</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incontinence</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myoblasts</subject><subject>Myoblasts, Skeletal - cytology</subject><subject>Myoblasts, Skeletal - transplantation</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Quality of Life</subject><subject>Rhabdosphincter</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem cells</subject><subject>Transplantation, Autologous</subject><subject>Transurethral ultrasound</subject><subject>Treatment Outcome</subject><subject>Urethra</subject><subject>Urinary Bladder</subject><subject>Urinary Incontinence, Stress - diagnostic imaging</subject><subject>Urinary Incontinence, Stress - physiopathology</subject><subject>Urinary Incontinence, Stress - surgery</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Urodynamics</subject><subject>Urology</subject><issn>0302-2838</issn><issn>1873-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUgIModlv9D0TmordZ8zuTg0JZbC0UPLQ9h0zyBrPOZNZkRtj_3oRdKHgpBAIv33t5-fIQ-kDwlmAiv-y3sKY1zVuKsdrWReUrtCGdYq0SEr9GG8wwbWnHugt0mfMeY8yEZm_RBVGyRAXdoK_Xfh2X5mGBqdnBODaPvyDZw7GZh-YGJjtCOUuQc_OUQrTp2NxFN8clRIgO3qE3gx0zvD_vV-jp5vvj7kd7__P2bnd93zrB6dL2FDjWPbHQdXRQQ--J5ooDdF4r6XrpibAC-4HWEFPKSy11z4SnBKTm7Ap9PtU9pPnPCnkxU8iutGsjzGs2CmPNOVYvgkQzRTkXBeQn0KU55wSDOaQwlfcZgk31a_bm5NdUv6YuKkvax3P9tZ_APyedhRbg0xmw2dlxSDa6kJ853WkhWVe4bycOira_AZLJLlSlPiRwi_FzeKmT_wu4McRQ7vwNR8j7eU2xfIkhJlODzUOdhToKuLqqY_APc5ausQ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Mitterberger, Michael</creator><creator>Pinggera, Germar-Michael</creator><creator>Marksteiner, Rainer</creator><creator>Margreiter, Eva</creator><creator>Fussenegger, Martin</creator><creator>Frauscher, Ferdinand</creator><creator>Ulmer, Hanno</creator><creator>Hering, Steffen</creator><creator>Bartsch, Georg</creator><creator>Strasser, Hannes</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Adult Stem Cell Therapy of Female Stress Urinary Incontinence</title><author>Mitterberger, Michael ; Pinggera, Germar-Michael ; Marksteiner, Rainer ; Margreiter, Eva ; Fussenegger, Martin ; Frauscher, Ferdinand ; Ulmer, Hanno ; Hering, Steffen ; Bartsch, Georg ; Strasser, Hannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-b2e409b1ae882f7fbd19474ee8d976cb6d15a50df2ee8d377d6969b35d21e6943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cells, Cultured</topic><topic>Electromyography</topic><topic>Endosonography</topic><topic>Female</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - transplantation</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incontinence</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myoblasts</topic><topic>Myoblasts, Skeletal - cytology</topic><topic>Myoblasts, Skeletal - transplantation</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Quality of Life</topic><topic>Rhabdosphincter</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem cells</topic><topic>Transplantation, Autologous</topic><topic>Transurethral ultrasound</topic><topic>Treatment Outcome</topic><topic>Urethra</topic><topic>Urinary Bladder</topic><topic>Urinary Incontinence, Stress - diagnostic imaging</topic><topic>Urinary Incontinence, Stress - physiopathology</topic><topic>Urinary Incontinence, Stress - surgery</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Urodynamics</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitterberger, Michael</creatorcontrib><creatorcontrib>Pinggera, Germar-Michael</creatorcontrib><creatorcontrib>Marksteiner, Rainer</creatorcontrib><creatorcontrib>Margreiter, Eva</creatorcontrib><creatorcontrib>Fussenegger, Martin</creatorcontrib><creatorcontrib>Frauscher, Ferdinand</creatorcontrib><creatorcontrib>Ulmer, Hanno</creatorcontrib><creatorcontrib>Hering, Steffen</creatorcontrib><creatorcontrib>Bartsch, Georg</creatorcontrib><creatorcontrib>Strasser, Hannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitterberger, Michael</au><au>Pinggera, Germar-Michael</au><au>Marksteiner, Rainer</au><au>Margreiter, Eva</au><au>Fussenegger, Martin</au><au>Frauscher, Ferdinand</au><au>Ulmer, Hanno</au><au>Hering, Steffen</au><au>Bartsch, Georg</au><au>Strasser, Hannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult Stem Cell Therapy of Female Stress Urinary Incontinence</atitle><jtitle>European urology</jtitle><addtitle>Eur Urol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>53</volume><issue>1</issue><spage>169</spage><epage>175</epage><pages>169-175</pages><issn>0302-2838</issn><eissn>1873-7560</eissn><coden>EUURAV</coden><abstract>Abstract Objectives To investigate the efficacy of transurethral ultrasound (TUUS)-guided injections of autologous myoblasts and fibroblasts in women with incontinence. Methods Between January and June 2005, 20 female patients suffering from stress urinary incontinence (SUI) were included. Skeletal muscle biopsies were taken from the left arm to obtain cultures from autologous fibroblasts and myoblasts. By TUUS guidance the fibroblasts were injected into the urethral submucosa and the myoblasts were injected into the rhabdosphincter. A defined incontinence score, quality-of-life score and urodynamic, electromyographic, and laboratory parameters, as well as morphology and function of urethra and rhabdosphincter were evaluated before and up to 2 yr after therapy. Results Eigtheen of 20 patients were cured 1 yr after injection of autologous stem cells and in 2 patients SUI was improved. Two years after therapy 16 of the 18 patients presented as cured, 2 others were improved, and 2 were lost to follow-up. Incontinence and quality-of-life scores were significantly improved postoperatively. The thickness of urethra and rhabdosphincter as well as activity and contractility of the rhabdosphincter were also statistically significantly increased after therapy. Conclusions Clinical results demonstrate that SUI can be treated effectively with autologous stem cells. The present data support the conclusion that this therapeutic concept represents an elegant and minimally invasive treatment modality to treat SUI.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>17683852</pmid><doi>10.1016/j.eururo.2007.07.026</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Biopsy Cells, Cultured Electromyography Endosonography Female Fibroblasts - cytology Fibroblasts - transplantation Follow-Up Studies Humans Incontinence Injections Medical sciences Middle Aged Myoblasts Myoblasts, Skeletal - cytology Myoblasts, Skeletal - transplantation Nephrology. Urinary tract diseases Quality of Life Rhabdosphincter Stem Cell Transplantation - methods Stem cells Transplantation, Autologous Transurethral ultrasound Treatment Outcome Urethra Urinary Bladder Urinary Incontinence, Stress - diagnostic imaging Urinary Incontinence, Stress - physiopathology Urinary Incontinence, Stress - surgery Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urodynamics Urology |
| title | Adult Stem Cell Therapy of Female Stress Urinary Incontinence |
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