Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes
Abstract Cerebellar disturbances can induce a variety of motor deficits, ranging from severe ataxia to mild deficits of fine motor control. Although motor disturbances appear as an important clinical feature in many neurological disorders, mild disturbances are often difficult to assess properly. Ey...
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| Veröffentlicht in: | Parkinsonism & related disorders 2007, Vol.13, p.S296-S300 |
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| container_title | Parkinsonism & related disorders |
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| creator | van Broekhoven, P.C.A Frens, M.A Sillevis Smitt, P.A van der Geest, J.N |
| description | Abstract Cerebellar disturbances can induce a variety of motor deficits, ranging from severe ataxia to mild deficits of fine motor control. Although motor disturbances appear as an important clinical feature in many neurological disorders, mild disturbances are often difficult to assess properly. Eye movement recordings using video-oculography in a group of patients with a paraneoplastic neurological disorder revealed subtle saccadic and smooth pursuit deficits when compared to controls. We conclude that an easy quantification of eye movement control may assist in the diagnosis and follow-up of mild motor disturbances in patients with neurological disorders, especially when such signs are not overt during clinical neurological examination. |
| doi_str_mv | 10.1016/S1353-8020(08)70019-1 |
| format | Article |
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Although motor disturbances appear as an important clinical feature in many neurological disorders, mild disturbances are often difficult to assess properly. Eye movement recordings using video-oculography in a group of patients with a paraneoplastic neurological disorder revealed subtle saccadic and smooth pursuit deficits when compared to controls. We conclude that an easy quantification of eye movement control may assist in the diagnosis and follow-up of mild motor disturbances in patients with neurological disorders, especially when such signs are not overt during clinical neurological examination.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/S1353-8020(08)70019-1</identifier><identifier>PMID: 18267253</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Cerebellar Neoplasms - diagnosis ; Cerebellar Neoplasms - physiopathology ; Cerebellum - pathology ; Cerebellum - physiopathology ; Electrooculography ; Eye movements ; Eye Movements - physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor deficits ; Neurology ; Paraneoplastic Cerebellar Degeneration - diagnosis ; Paraneoplastic Cerebellar Degeneration - physiopathology ; Paraneoplastic neurological syndromes ; Syndrome ; Video-oculography</subject><ispartof>Parkinsonism & related disorders, 2007, Vol.13, p.S296-S300</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-7c325c02856d8f72e433597ff20a61729b5d635ca32721ab8ebde6aa9a94f2743</citedby><cites>FETCH-LOGICAL-c418t-7c325c02856d8f72e433597ff20a61729b5d635ca32721ab8ebde6aa9a94f2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1353-8020(08)70019-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18267253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Broekhoven, P.C.A</creatorcontrib><creatorcontrib>Frens, M.A</creatorcontrib><creatorcontrib>Sillevis Smitt, P.A</creatorcontrib><creatorcontrib>van der Geest, J.N</creatorcontrib><title>Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract Cerebellar disturbances can induce a variety of motor deficits, ranging from severe ataxia to mild deficits of fine motor control. 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We conclude that an easy quantification of eye movement control may assist in the diagnosis and follow-up of mild motor disturbances in patients with neurological disorders, especially when such signs are not overt during clinical neurological examination.</description><subject>Aged</subject><subject>Cerebellar Neoplasms - diagnosis</subject><subject>Cerebellar Neoplasms - physiopathology</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - physiopathology</subject><subject>Electrooculography</subject><subject>Eye movements</subject><subject>Eye Movements - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor deficits</subject><subject>Neurology</subject><subject>Paraneoplastic Cerebellar Degeneration - diagnosis</subject><subject>Paraneoplastic Cerebellar Degeneration - physiopathology</subject><subject>Paraneoplastic neurological syndromes</subject><subject>Syndrome</subject><subject>Video-oculography</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoyce2P6FFp5Ic3Iwky5IvKSXkoxDIoS30JmR5HJTY1layA_vvI-9uKORSEIwO7zwz8xDyicFXBqw6_8mEFIUGDqegzxQAqwt2QI6ZVqKQjFfv8v81ckROUnoEACVBHJIjpnmluBTH5M_VBukQnnHAcUrU5kcHG58w0i5E6jBig31vI23tYB-Q-pGubbQjhnVv0-QdHXGOoQ8P3tmeps3YxjBg-kDed7ZP-HFfV-T39dWvy9vi7v7mx-X3u8KVTE-FcoJLB1zLqtWd4lgKIWvVdRxsxRSvG9lWQjoruOLMNhqbFitra1uXHVelWJEvO-46hr8zpskMPrll5bzinEw2U5ciS1kRuQu6GFKK2Jl19PnUjWFgFqVmq9Qsvgxos1VqWO77vB8wNwO2_7r2DnPg2y6A-cxnj9Ek53F02PqIbjJt8P8dcfGG4Ho_Lj6fcIPpMcxxzA4NM4kb2EEWBugtgYkXamya-A</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>van Broekhoven, P.C.A</creator><creator>Frens, M.A</creator><creator>Sillevis Smitt, P.A</creator><creator>van der Geest, J.N</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes</title><author>van Broekhoven, P.C.A ; Frens, M.A ; Sillevis Smitt, P.A ; van der Geest, J.N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-7c325c02856d8f72e433597ff20a61729b5d635ca32721ab8ebde6aa9a94f2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Cerebellar Neoplasms - diagnosis</topic><topic>Cerebellar Neoplasms - physiopathology</topic><topic>Cerebellum - pathology</topic><topic>Cerebellum - physiopathology</topic><topic>Electrooculography</topic><topic>Eye movements</topic><topic>Eye Movements - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor deficits</topic><topic>Neurology</topic><topic>Paraneoplastic Cerebellar Degeneration - diagnosis</topic><topic>Paraneoplastic Cerebellar Degeneration - physiopathology</topic><topic>Paraneoplastic neurological syndromes</topic><topic>Syndrome</topic><topic>Video-oculography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Broekhoven, P.C.A</creatorcontrib><creatorcontrib>Frens, M.A</creatorcontrib><creatorcontrib>Sillevis Smitt, P.A</creatorcontrib><creatorcontrib>van der Geest, J.N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Broekhoven, P.C.A</au><au>Frens, M.A</au><au>Sillevis Smitt, P.A</au><au>van der Geest, J.N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2007</date><risdate>2007</risdate><volume>13</volume><spage>S296</spage><epage>S300</epage><pages>S296-S300</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract Cerebellar disturbances can induce a variety of motor deficits, ranging from severe ataxia to mild deficits of fine motor control. Although motor disturbances appear as an important clinical feature in many neurological disorders, mild disturbances are often difficult to assess properly. Eye movement recordings using video-oculography in a group of patients with a paraneoplastic neurological disorder revealed subtle saccadic and smooth pursuit deficits when compared to controls. We conclude that an easy quantification of eye movement control may assist in the diagnosis and follow-up of mild motor disturbances in patients with neurological disorders, especially when such signs are not overt during clinical neurological examination.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18267253</pmid><doi>10.1016/S1353-8020(08)70019-1</doi></addata></record> |
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| ispartof | Parkinsonism & related disorders, 2007, Vol.13, p.S296-S300 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Cerebellar Neoplasms - diagnosis Cerebellar Neoplasms - physiopathology Cerebellum - pathology Cerebellum - physiopathology Electrooculography Eye movements Eye Movements - physiology Female Humans Magnetic Resonance Imaging Male Middle Aged Motor deficits Neurology Paraneoplastic Cerebellar Degeneration - diagnosis Paraneoplastic Cerebellar Degeneration - physiopathology Paraneoplastic neurological syndromes Syndrome Video-oculography |
| title | Eye movements as a marker for cerebellar damage in paraneoplastic neurological syndromes |
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