Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis

Multiple sclerosis (MS) is an autoimmune, neurological disability with unknown etiology. The current therapies available for MS work by an immunomodulatory action, preventing T-cell- and macrophage-mediated destruction of brain-resident oligodendrocytes and axonal loss. Recently, FTY720 (fingolimod)...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2008-01, Vol.117 (1), p.77-93
Hauptverfasser:	Dev, Kumlesh K, Mullershausen, Florian, Mattes, Henri, Kuhn, Rainer R, Bilbe, Graeme, Hoyer, Daniel, Mir, Anis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - physiopathology Drug Delivery Systems Fingolimod Hydrochloride Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Multiple Sclerosis - drug therapy Multiple Sclerosis - physiopathology Propylene Glycols - pharmacology Propylene Glycols - therapeutic use Receptors, Lysosphingolipid - drug effects Receptors, Lysosphingolipid - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine - therapeutic use
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