NT-proBNP is not elevated in patients with obstructive sleep apnoea
Summary Background N-terminal pro-brain natriuretic peptide (NT-ProBNP) has emerged as an important marker of cardiac stress and may reflect the severity of underlying cardiac dysfunction, which is thought to be associated with obstructive sleep apnoea syndrome (OSAS). Methods This study evaluated t...
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| Veröffentlicht in: | Respiratory medicine 2008-01, Vol.102 (1), p.134-142 |
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| creator | Hübner, Ralf-Harto El Mokhtari, Nour Eddine Freitag, Sandra Rausche, Tim Göder, Robert Tiroke, Andreas Lins, Markus Simon, Rüdiger Bewig, Burkhard |
| description | Summary Background N-terminal pro-brain natriuretic peptide (NT-ProBNP) has emerged as an important marker of cardiac stress and may reflect the severity of underlying cardiac dysfunction, which is thought to be associated with obstructive sleep apnoea syndrome (OSAS). Methods This study evaluated the plasma concentration of NT-ProBNP in 60 consecutive patients (median age 55.7 years, median body mass index (BMI) 31.8) who were referred to a sleep laboratory with a suspicion of OSAS. Each subject underwent measurement of morning NT-ProBNP plasma levels, polysomnography and echocardiography. Patients were treated with nasal continuous or bilevel positive airway pressure ventilation (nCPAP/BIPAP) or without mechanical respiratory support, depending on clinical symptoms and results of polysomnography. Three months after treatment of OSAS 28 of the patients were reassessed for re-evaluation of NT-ProBNP and polysomnography. Results Low or high levels of NT-proBNP were not associated with AHI and other sleep related indices ( p >0.3). There was no correlation between NT-proBNP and AHI or other sleep related indices. In multiple regression analysis, NT-proBNP was significantly correlated with left ventricular ejection fraction, creatinine clearance and the presence of systemic arterial hypertension but not with AHI. Conclusions Our results show by a robust multiple regression analysis, that NT-pro BNP is not associated with OSAS and NT-pro BNP cannot be used as a sensitive marker for underlying cardiovascular abnormalities in patients with OSAS. |
| doi_str_mv | 10.1016/j.rmed.2007.07.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70092364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0954611107003290</els_id><sourcerecordid>70092364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-e8ecdea15fa6f394f8639d343e483a4f6ff43b97d3719c96461a4ca0f92de98f3</originalsourceid><addsrcrecordid>eNp9kltr3DAQhUVpabZJ_0AegiA0b97qZtmCUGiX3iAkhabPQiuPiDZe25HkDfn3ldilgTwUDehB34zOOQxCp5QsKaHy42YZttAtGSHNshTjr9CC1pxVnEjxGi2IqkUlKaVH6F2MG0KIEoK8RUe0aRXLZ4FW17fVFMYv17-wj3gYE4YediZBh_2AJ5M8DCniR5_u8LiOKcw2-R3g2ANM2EzDCOYEvXGmj_D-cB-jP9--3q5-VFc333-uPl9VtqY0VdCC7cDQ2hnpuBKulVx1XHAQLTfCSecEX6um4w1VVkkhqRHWEKdYB6p1_Bhd7OdmwQ8zxKS3PlroezPAOEfdZH-MS5HB8xfgZpzDkLVpSnhNhBSKZortKRvGGAM4PQW_NeEpQ7oErDe6BKxLwLoU47np7DB6Xpe3fy2HRDPw4QCYaE3vghmsj8-cysYUKYMu9xzkxHYego42Z22h8wFs0t3o_6_j04t22_vB5x_v4Qnis18dmSb6d1mFsgkkh8RZFvAXvZasrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035046491</pqid></control><display><type>article</type><title>NT-proBNP is not elevated in patients with obstructive sleep apnoea</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hübner, Ralf-Harto ; El Mokhtari, Nour Eddine ; Freitag, Sandra ; Rausche, Tim ; Göder, Robert ; Tiroke, Andreas ; Lins, Markus ; Simon, Rüdiger ; Bewig, Burkhard</creator><creatorcontrib>Hübner, Ralf-Harto ; El Mokhtari, Nour Eddine ; Freitag, Sandra ; Rausche, Tim ; Göder, Robert ; Tiroke, Andreas ; Lins, Markus ; Simon, Rüdiger ; Bewig, Burkhard</creatorcontrib><description>Summary Background N-terminal pro-brain natriuretic peptide (NT-ProBNP) has emerged as an important marker of cardiac stress and may reflect the severity of underlying cardiac dysfunction, which is thought to be associated with obstructive sleep apnoea syndrome (OSAS). Methods This study evaluated the plasma concentration of NT-ProBNP in 60 consecutive patients (median age 55.7 years, median body mass index (BMI) 31.8) who were referred to a sleep laboratory with a suspicion of OSAS. Each subject underwent measurement of morning NT-ProBNP plasma levels, polysomnography and echocardiography. Patients were treated with nasal continuous or bilevel positive airway pressure ventilation (nCPAP/BIPAP) or without mechanical respiratory support, depending on clinical symptoms and results of polysomnography. Three months after treatment of OSAS 28 of the patients were reassessed for re-evaluation of NT-ProBNP and polysomnography. Results Low or high levels of NT-proBNP were not associated with AHI and other sleep related indices ( p >0.3). There was no correlation between NT-proBNP and AHI or other sleep related indices. In multiple regression analysis, NT-proBNP was significantly correlated with left ventricular ejection fraction, creatinine clearance and the presence of systemic arterial hypertension but not with AHI. Conclusions Our results show by a robust multiple regression analysis, that NT-pro BNP is not associated with OSAS and NT-pro BNP cannot be used as a sensitive marker for underlying cardiovascular abnormalities in patients with OSAS.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2007.07.023</identifier><identifier>PMID: 17892929</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Agreements ; Biological and medical sciences ; Biomarkers - blood ; BNP ; Body mass index ; Confidence intervals ; Female ; Females ; Heart disease ; Heart Diseases - complications ; Heart Diseases - metabolism ; Heart failure ; Hormone replacement therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Multivariate analysis ; Natriuretic Peptide, Brain - blood ; Natriuretic peptides ; NT-proBNP ; Obesity ; OSAS ; Peptide Fragments - blood ; Peptides ; Pneumology ; Polysomnography - methods ; Predictive Value of Tests ; Pulmonary/Respiratory ; Regression Analysis ; Respiratory system : syndromes and miscellaneous diseases ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - therapy</subject><ispartof>Respiratory medicine, 2008-01, Vol.102 (1), p.134-142</ispartof><rights>2007</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-e8ecdea15fa6f394f8639d343e483a4f6ff43b97d3719c96461a4ca0f92de98f3</citedby><cites>FETCH-LOGICAL-c511t-e8ecdea15fa6f394f8639d343e483a4f6ff43b97d3719c96461a4ca0f92de98f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611107003290$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19964903$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17892929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hübner, Ralf-Harto</creatorcontrib><creatorcontrib>El Mokhtari, Nour Eddine</creatorcontrib><creatorcontrib>Freitag, Sandra</creatorcontrib><creatorcontrib>Rausche, Tim</creatorcontrib><creatorcontrib>Göder, Robert</creatorcontrib><creatorcontrib>Tiroke, Andreas</creatorcontrib><creatorcontrib>Lins, Markus</creatorcontrib><creatorcontrib>Simon, Rüdiger</creatorcontrib><creatorcontrib>Bewig, Burkhard</creatorcontrib><title>NT-proBNP is not elevated in patients with obstructive sleep apnoea</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Background N-terminal pro-brain natriuretic peptide (NT-ProBNP) has emerged as an important marker of cardiac stress and may reflect the severity of underlying cardiac dysfunction, which is thought to be associated with obstructive sleep apnoea syndrome (OSAS). Methods This study evaluated the plasma concentration of NT-ProBNP in 60 consecutive patients (median age 55.7 years, median body mass index (BMI) 31.8) who were referred to a sleep laboratory with a suspicion of OSAS. Each subject underwent measurement of morning NT-ProBNP plasma levels, polysomnography and echocardiography. Patients were treated with nasal continuous or bilevel positive airway pressure ventilation (nCPAP/BIPAP) or without mechanical respiratory support, depending on clinical symptoms and results of polysomnography. Three months after treatment of OSAS 28 of the patients were reassessed for re-evaluation of NT-ProBNP and polysomnography. Results Low or high levels of NT-proBNP were not associated with AHI and other sleep related indices ( p >0.3). There was no correlation between NT-proBNP and AHI or other sleep related indices. In multiple regression analysis, NT-proBNP was significantly correlated with left ventricular ejection fraction, creatinine clearance and the presence of systemic arterial hypertension but not with AHI. Conclusions Our results show by a robust multiple regression analysis, that NT-pro BNP is not associated with OSAS and NT-pro BNP cannot be used as a sensitive marker for underlying cardiovascular abnormalities in patients with OSAS.</description><subject>Adult</subject><subject>Agreements</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>BNP</subject><subject>Body mass index</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Females</subject><subject>Heart disease</subject><subject>Heart Diseases - complications</subject><subject>Heart Diseases - metabolism</subject><subject>Heart failure</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Natriuretic peptides</subject><subject>NT-proBNP</subject><subject>Obesity</subject><subject>OSAS</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Pneumology</subject><subject>Polysomnography - methods</subject><subject>Predictive Value of Tests</subject><subject>Pulmonary/Respiratory</subject><subject>Regression Analysis</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - therapy</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kltr3DAQhUVpabZJ_0AegiA0b97qZtmCUGiX3iAkhabPQiuPiDZe25HkDfn3ldilgTwUDehB34zOOQxCp5QsKaHy42YZttAtGSHNshTjr9CC1pxVnEjxGi2IqkUlKaVH6F2MG0KIEoK8RUe0aRXLZ4FW17fVFMYv17-wj3gYE4YediZBh_2AJ5M8DCniR5_u8LiOKcw2-R3g2ANM2EzDCOYEvXGmj_D-cB-jP9--3q5-VFc333-uPl9VtqY0VdCC7cDQ2hnpuBKulVx1XHAQLTfCSecEX6um4w1VVkkhqRHWEKdYB6p1_Bhd7OdmwQ8zxKS3PlroezPAOEfdZH-MS5HB8xfgZpzDkLVpSnhNhBSKZortKRvGGAM4PQW_NeEpQ7oErDe6BKxLwLoU47np7DB6Xpe3fy2HRDPw4QCYaE3vghmsj8-cysYUKYMu9xzkxHYego42Z22h8wFs0t3o_6_j04t22_vB5x_v4Qnis18dmSb6d1mFsgkkh8RZFvAXvZasrQ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Hübner, Ralf-Harto</creator><creator>El Mokhtari, Nour Eddine</creator><creator>Freitag, Sandra</creator><creator>Rausche, Tim</creator><creator>Göder, Robert</creator><creator>Tiroke, Andreas</creator><creator>Lins, Markus</creator><creator>Simon, Rüdiger</creator><creator>Bewig, Burkhard</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>NT-proBNP is not elevated in patients with obstructive sleep apnoea</title><author>Hübner, Ralf-Harto ; El Mokhtari, Nour Eddine ; Freitag, Sandra ; Rausche, Tim ; Göder, Robert ; Tiroke, Andreas ; Lins, Markus ; Simon, Rüdiger ; Bewig, Burkhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-e8ecdea15fa6f394f8639d343e483a4f6ff43b97d3719c96461a4ca0f92de98f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Agreements</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>BNP</topic><topic>Body mass index</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Females</topic><topic>Heart disease</topic><topic>Heart Diseases - complications</topic><topic>Heart Diseases - metabolism</topic><topic>Heart failure</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Natriuretic peptides</topic><topic>NT-proBNP</topic><topic>Obesity</topic><topic>OSAS</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Pneumology</topic><topic>Polysomnography - methods</topic><topic>Predictive Value of Tests</topic><topic>Pulmonary/Respiratory</topic><topic>Regression Analysis</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hübner, Ralf-Harto</creatorcontrib><creatorcontrib>El Mokhtari, Nour Eddine</creatorcontrib><creatorcontrib>Freitag, Sandra</creatorcontrib><creatorcontrib>Rausche, Tim</creatorcontrib><creatorcontrib>Göder, Robert</creatorcontrib><creatorcontrib>Tiroke, Andreas</creatorcontrib><creatorcontrib>Lins, Markus</creatorcontrib><creatorcontrib>Simon, Rüdiger</creatorcontrib><creatorcontrib>Bewig, Burkhard</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hübner, Ralf-Harto</au><au>El Mokhtari, Nour Eddine</au><au>Freitag, Sandra</au><au>Rausche, Tim</au><au>Göder, Robert</au><au>Tiroke, Andreas</au><au>Lins, Markus</au><au>Simon, Rüdiger</au><au>Bewig, Burkhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NT-proBNP is not elevated in patients with obstructive sleep apnoea</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>102</volume><issue>1</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Background N-terminal pro-brain natriuretic peptide (NT-ProBNP) has emerged as an important marker of cardiac stress and may reflect the severity of underlying cardiac dysfunction, which is thought to be associated with obstructive sleep apnoea syndrome (OSAS). Methods This study evaluated the plasma concentration of NT-ProBNP in 60 consecutive patients (median age 55.7 years, median body mass index (BMI) 31.8) who were referred to a sleep laboratory with a suspicion of OSAS. Each subject underwent measurement of morning NT-ProBNP plasma levels, polysomnography and echocardiography. Patients were treated with nasal continuous or bilevel positive airway pressure ventilation (nCPAP/BIPAP) or without mechanical respiratory support, depending on clinical symptoms and results of polysomnography. Three months after treatment of OSAS 28 of the patients were reassessed for re-evaluation of NT-ProBNP and polysomnography. Results Low or high levels of NT-proBNP were not associated with AHI and other sleep related indices ( p >0.3). There was no correlation between NT-proBNP and AHI or other sleep related indices. In multiple regression analysis, NT-proBNP was significantly correlated with left ventricular ejection fraction, creatinine clearance and the presence of systemic arterial hypertension but not with AHI. Conclusions Our results show by a robust multiple regression analysis, that NT-pro BNP is not associated with OSAS and NT-pro BNP cannot be used as a sensitive marker for underlying cardiovascular abnormalities in patients with OSAS.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17892929</pmid><doi>10.1016/j.rmed.2007.07.023</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Agreements Biological and medical sciences Biomarkers - blood BNP Body mass index Confidence intervals Female Females Heart disease Heart Diseases - complications Heart Diseases - metabolism Heart failure Hormone replacement therapy Humans Male Medical sciences Middle Aged Multivariate analysis Natriuretic Peptide, Brain - blood Natriuretic peptides NT-proBNP Obesity OSAS Peptide Fragments - blood Peptides Pneumology Polysomnography - methods Predictive Value of Tests Pulmonary/Respiratory Regression Analysis Respiratory system : syndromes and miscellaneous diseases Sleep Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - therapy |
| title | NT-proBNP is not elevated in patients with obstructive sleep apnoea |
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