Thrombophilia as a multigenic disorder
Substantial progress has been made in the study of inherited abnormalities that predispose to venous thrombosis. With new discoveries, the focus has shifted from rare deficiencies associated with high probability for events to relatively common aberrations that produce high risk only in combination....
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| Veröffentlicht in: | Seminars in thrombosis and hemostasis 1998, Vol.24, p.13-20 |
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| container_title | Seminars in thrombosis and hemostasis |
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| creator | MILETICH, J. P |
| description | Substantial progress has been made in the study of inherited abnormalities that predispose to venous thrombosis. With new discoveries, the focus has shifted from rare deficiencies associated with high probability for events to relatively common aberrations that produce high risk only in combination. Interactions between inherited and acquired disorders are also attracting much attention. The challenge for the future is how to best discover new risk factors and understand their contributions to multifactorial events. |
| format | Article |
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P</creator><creatorcontrib>MILETICH, J. P</creatorcontrib><description>Substantial progress has been made in the study of inherited abnormalities that predispose to venous thrombosis. With new discoveries, the focus has shifted from rare deficiencies associated with high probability for events to relatively common aberrations that produce high risk only in combination. Interactions between inherited and acquired disorders are also attracting much attention. 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P</creatorcontrib><title>Thrombophilia as a multigenic disorder</title><title>Seminars in thrombosis and hemostasis</title><addtitle>Semin Thromb Hemost</addtitle><description>Substantial progress has been made in the study of inherited abnormalities that predispose to venous thrombosis. With new discoveries, the focus has shifted from rare deficiencies associated with high probability for events to relatively common aberrations that produce high risk only in combination. Interactions between inherited and acquired disorders are also attracting much attention. The challenge for the future is how to best discover new risk factors and understand their contributions to multifactorial events.</description><subject>Activated Protein C Resistance</subject><subject>Biological and medical sciences</subject><subject>Factor V - genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Platelet diseases and coagulopathies</subject><subject>Risk Factors</subject><subject>Thrombophilia - genetics</subject><issn>0094-6176</issn><issn>1098-9064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLxDAUhYMoYx39CUIXMrvCzWNuk6UMvmDAzbguaR5OJH2YtAv_vQWLq3PgfBz4LkhBQclKAYpLUgAoUSGt8Zrc5PwFQIUEtiEbJQWglAXZnc5p6NphPIcYdKlzqctujlP4dH0wpQ15SNalW3Lldczubs0t-Xh-Oh1eq-P7y9vh8ViNjO-nynDgzhkNSxE154J6S41X0hh0TAumFFXUMmssgxqRU9W26D1H1wpPFd-S3d_vmIbv2eWp6UI2Lkbdu2HOTb0YMSb3C3i_gnPbOduMKXQ6_TSr2LI_rLvORkefdG9C_scoMkDO-C_3EVYe</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>MILETICH, J. 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P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-c303eeca0c30473341fd1cf98cc6e2a4299191d2dcd20766319bb6ff36eb4f193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Activated Protein C Resistance</topic><topic>Biological and medical sciences</topic><topic>Factor V - genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Platelet diseases and coagulopathies</topic><topic>Risk Factors</topic><topic>Thrombophilia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILETICH, J. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in thrombosis and hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILETICH, J. P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombophilia as a multigenic disorder</atitle><jtitle>Seminars in thrombosis and hemostasis</jtitle><addtitle>Semin Thromb Hemost</addtitle><date>1998</date><risdate>1998</risdate><volume>24</volume><spage>13</spage><epage>20</epage><pages>13-20</pages><issn>0094-6176</issn><eissn>1098-9064</eissn><coden>STHMBV</coden><abstract>Substantial progress has been made in the study of inherited abnormalities that predispose to venous thrombosis. With new discoveries, the focus has shifted from rare deficiencies associated with high probability for events to relatively common aberrations that produce high risk only in combination. Interactions between inherited and acquired disorders are also attracting much attention. The challenge for the future is how to best discover new risk factors and understand their contributions to multifactorial events.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>9840688</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-6176 |
| ispartof | Seminars in thrombosis and hemostasis, 1998, Vol.24, p.13-20 |
| issn | 0094-6176 1098-9064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70092285 |
| source | Thieme - Connect here FIRST to enable access; MEDLINE |
| subjects | Activated Protein C Resistance Biological and medical sciences Factor V - genetics Hematologic and hematopoietic diseases Humans Medical sciences Mutation Platelet diseases and coagulopathies Risk Factors Thrombophilia - genetics |
| title | Thrombophilia as a multigenic disorder |
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