Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity

As enhanced chromosomal radiosensitivity (CRS) results from non‐ or misrepaired double strand breaks (DSBs) and is a hallmark for breast cancer and single nucleotide polymorphisms (SNPs) in DSB repair genes, such as non homologous end‐joining (NHEJ) genes, could be involved in CRS and genetic predis...

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Veröffentlicht in:	Genes chromosomes & cancer 2008-02, Vol.47 (2), p.137-148
Hauptverfasser:	Willems, Petra, Claes, Kathleen, Baeyens, Ans, Vandersickel, Veerle, Werbrouck, Joke, De Ruyck, Kim, Poppe, Bruce, Van den Broecke, Rudy, Makar, Amin, Marras, Emanuela, Perletti, Gianpaolo, Thierens, Hubert, Vral, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Base Sequence Breast Neoplasms - enzymology Breast Neoplasms - genetics Case-Control Studies DNA Repair - genetics Female Genetic Predisposition to Disease Humans Middle Aged Molecular Sequence Data Polymorphism, Single Nucleotide Radiation Tolerance - genetics Risk Factors
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