Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization

STRADalpha is a pseudokinase that forms a heterotrimeric complex with the scaffolding protein MO25 and the tumor suppressor serine threonine protein kinase LKB1. Mutations in the LKB1 gene are responsible for the Peutz-Jeghers Syndrome (PJS) characterized by a predisposition to hamartomatous polyps...

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Veröffentlicht in:	Cancer biology & therapy 2007-10, Vol.6 (10), p.1627-1631
Hauptverfasser:	Marignani, P A, Scott, K D, Bagnulo, R, Cannone, D, Ferrari, E, Stella, A, Guanti, G, Simone, C, Resta, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Alternative Splicing Cell Differentiation Cell Line, Tumor Cell Polarity Colorectal Neoplasms - metabolism Enterocytes - cytology Humans Protein Isoforms - genetics Protein Isoforms - metabolism Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - metabolism Transcription, Genetic
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