Increased entropy production in diaphragm muscle of PPAR α knockout mice

Peroxisome proliferator activated receptor alpha (PPAR α) regulates fatty acid β-oxidation (FAO) and plays a central role in the metabolic and energetic homeostasis of striated muscles. The thermodynamic consequences of the absence of PPAR α were investigated in diaphragm muscle of PPAR α knockout m...

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Veröffentlicht in:	Journal of theoretical biology 2008-01, Vol.250 (1), p.92-102
Hauptverfasser:	Lecarpentier, Y., Krokidis, X., Martin, P., Pineau, T., Hébert, J.-L., Quillard, J., Cortes-Morichetti, M., Coirault, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Diaphragm - metabolism Diaphragm - pathology Diaphragm - physiopathology Diaphragm muscle Entropy Entropy production Gene Expression Regulation Male Mice Mice, Inbred C57BL Mice, Knockout Myosin Heavy Chains - analysis Myosins - metabolism PPAR alpha - biosynthesis PPAR alpha - deficiency PPAR alpha - genetics PPAR delta - biosynthesis PPAR delta - genetics PPAR gamma - biosynthesis PPAR gamma - genetics PPAR α Protein Isoforms - analysis Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics Statistical mechanics Thermo-energetics Thermodynamics
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