Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium
ABSTRACT The purpose of this study was to observe the magnitude and time course of changes in tissue edema in experimental free flaps. Thirty female Sprague Dawley rats underwent elevation and orthoptic transplantation of free epigastric skin flaps. Using a modified “wick in needle” technique, inter...
Gespeichert in:
| Veröffentlicht in: | Journal of reconstructive microsurgery 2007-08, Vol.23 (6), p.317-320 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 320 |
|---|---|
| container_issue | 6 |
| container_start_page | 317 |
| container_title | Journal of reconstructive microsurgery |
| container_volume | 23 |
| creator | Davidson, John S.D |
| description | ABSTRACT
The purpose of this study was to observe the magnitude and time course of changes in tissue edema in experimental free flaps. Thirty female Sprague Dawley rats underwent elevation and orthoptic transplantation of free epigastric skin flaps. Using a modified “wick in needle” technique, interstitial fluid pressure (IFP) was measured in the flaps at various times up to 2 weeks postoperatively. Increases in IFP to positive values were seen by 12 hours. IFP remained elevated for 3 to 5 days, after which they gradually returned to control values by 2 weeks. This is the first study to follow the time course and magnitude of changes in IFP and edema in free flaps. It is a useful animal model by which the hemodynamic effects of physical and pharmacological manipulation of flaps can be studied. |
| doi_str_mv | 10.1055/s-2007-992338 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70089631</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70089631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c358t-4e72d900956967b31211d51f0788663b914c92b3a9bb9f4b1e9a2bb7380249a73</originalsourceid><addsrcrecordid>eNp10M9LHDEYxvFQlLpue-xVcrEnxyaTmUneoyyuCkLLtpbeQjLzjkbnx5o3c2j_emfZBU89BcKH54UvY1-kuJSiLL9RlguhM4BcKfOBLaQAkxko9BFbCF2orDLFnxN2SvQshCxA5h_ZidSgS63lgm3uhoSRUkjBdXzdTaHhPyISTRF5GPg6IvLfjuqpczH8w4b_fNl9d25LfGx5ekK-cYlfb8OjoxTD1H9ix63rCD8f3iV7WF__Wt1m999v7lZX91mtSpOyAnXegBBQVlBpr2QuZVPKVmhjqkp5kEUNuVcOvIe28BLB5d5rZURegNNqyb7ud7dxfJ2Qku0D1dh1bsBxIquFMFApOcNsD-s4EkVs7TaG3sW_Vgq7i2jJ7iLafcTZnx2GJ99j864P1WZwfgBzGNe10Q11oHcHUM4z1ewu9i49BezRPo9THOYk_7n7BgkNhig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70089631</pqid></control><display><type>article</type><title>Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Davidson, John S.D</creator><creatorcontrib>Davidson, John S.D</creatorcontrib><description>ABSTRACT
The purpose of this study was to observe the magnitude and time course of changes in tissue edema in experimental free flaps. Thirty female Sprague Dawley rats underwent elevation and orthoptic transplantation of free epigastric skin flaps. Using a modified “wick in needle” technique, interstitial fluid pressure (IFP) was measured in the flaps at various times up to 2 weeks postoperatively. Increases in IFP to positive values were seen by 12 hours. IFP remained elevated for 3 to 5 days, after which they gradually returned to control values by 2 weeks. This is the first study to follow the time course and magnitude of changes in IFP and edema in free flaps. It is a useful animal model by which the hemodynamic effects of physical and pharmacological manipulation of flaps can be studied.</description><identifier>ISSN: 0743-684X</identifier><identifier>EISSN: 1098-8947</identifier><identifier>DOI: 10.1055/s-2007-992338</identifier><identifier>PMID: 17975771</identifier><identifier>CODEN: JRMIE2</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Abdomen - surgery ; Anastomosis, Surgical - methods ; Animals ; Biological and medical sciences ; Edema - physiopathology ; Extracellular Fluid - physiology ; Female ; Femoral Artery - surgery ; Femoral Nerve - surgery ; Femoral Vein - surgery ; General aspects ; Graft Survival ; Hemodynamics - physiology ; Medical sciences ; Microsurgery - methods ; Models, Animal ; Pressure ; Rats ; Rats, Sprague-Dawley ; Skin Transplantation - pathology ; Skin Transplantation - physiology ; Surgical Flaps - blood supply ; Surgical Flaps - physiology ; Suture Techniques ; Time Factors</subject><ispartof>Journal of reconstructive microsurgery, 2007-08, Vol.23 (6), p.317-320</ispartof><rights>Thieme Medical Publishers</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-4e72d900956967b31211d51f0788663b914c92b3a9bb9f4b1e9a2bb7380249a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-992338.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-992338$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3015,3016,27923,27924,54558,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19953836$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17975771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davidson, John S.D</creatorcontrib><title>Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium</title><title>Journal of reconstructive microsurgery</title><addtitle>J reconstr Microsurg</addtitle><description>ABSTRACT
The purpose of this study was to observe the magnitude and time course of changes in tissue edema in experimental free flaps. Thirty female Sprague Dawley rats underwent elevation and orthoptic transplantation of free epigastric skin flaps. Using a modified “wick in needle” technique, interstitial fluid pressure (IFP) was measured in the flaps at various times up to 2 weeks postoperatively. Increases in IFP to positive values were seen by 12 hours. IFP remained elevated for 3 to 5 days, after which they gradually returned to control values by 2 weeks. This is the first study to follow the time course and magnitude of changes in IFP and edema in free flaps. It is a useful animal model by which the hemodynamic effects of physical and pharmacological manipulation of flaps can be studied.</description><subject>Abdomen - surgery</subject><subject>Anastomosis, Surgical - methods</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Edema - physiopathology</subject><subject>Extracellular Fluid - physiology</subject><subject>Female</subject><subject>Femoral Artery - surgery</subject><subject>Femoral Nerve - surgery</subject><subject>Femoral Vein - surgery</subject><subject>General aspects</subject><subject>Graft Survival</subject><subject>Hemodynamics - physiology</subject><subject>Medical sciences</subject><subject>Microsurgery - methods</subject><subject>Models, Animal</subject><subject>Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skin Transplantation - pathology</subject><subject>Skin Transplantation - physiology</subject><subject>Surgical Flaps - blood supply</subject><subject>Surgical Flaps - physiology</subject><subject>Suture Techniques</subject><subject>Time Factors</subject><issn>0743-684X</issn><issn>1098-8947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9LHDEYxvFQlLpue-xVcrEnxyaTmUneoyyuCkLLtpbeQjLzjkbnx5o3c2j_emfZBU89BcKH54UvY1-kuJSiLL9RlguhM4BcKfOBLaQAkxko9BFbCF2orDLFnxN2SvQshCxA5h_ZidSgS63lgm3uhoSRUkjBdXzdTaHhPyISTRF5GPg6IvLfjuqpczH8w4b_fNl9d25LfGx5ekK-cYlfb8OjoxTD1H9ix63rCD8f3iV7WF__Wt1m999v7lZX91mtSpOyAnXegBBQVlBpr2QuZVPKVmhjqkp5kEUNuVcOvIe28BLB5d5rZURegNNqyb7ud7dxfJ2Qku0D1dh1bsBxIquFMFApOcNsD-s4EkVs7TaG3sW_Vgq7i2jJ7iLafcTZnx2GJ99j864P1WZwfgBzGNe10Q11oHcHUM4z1ewu9i49BezRPo9THOYk_7n7BgkNhig</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Davidson, John S.D</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium</title><author>Davidson, John S.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-4e72d900956967b31211d51f0788663b914c92b3a9bb9f4b1e9a2bb7380249a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Abdomen - surgery</topic><topic>Anastomosis, Surgical - methods</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Edema - physiopathology</topic><topic>Extracellular Fluid - physiology</topic><topic>Female</topic><topic>Femoral Artery - surgery</topic><topic>Femoral Nerve - surgery</topic><topic>Femoral Vein - surgery</topic><topic>General aspects</topic><topic>Graft Survival</topic><topic>Hemodynamics - physiology</topic><topic>Medical sciences</topic><topic>Microsurgery - methods</topic><topic>Models, Animal</topic><topic>Pressure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skin Transplantation - pathology</topic><topic>Skin Transplantation - physiology</topic><topic>Surgical Flaps - blood supply</topic><topic>Surgical Flaps - physiology</topic><topic>Suture Techniques</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davidson, John S.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reconstructive microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davidson, John S.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium</atitle><jtitle>Journal of reconstructive microsurgery</jtitle><addtitle>J reconstr Microsurg</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>23</volume><issue>6</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>0743-684X</issn><eissn>1098-8947</eissn><coden>JRMIE2</coden><abstract>ABSTRACT
The purpose of this study was to observe the magnitude and time course of changes in tissue edema in experimental free flaps. Thirty female Sprague Dawley rats underwent elevation and orthoptic transplantation of free epigastric skin flaps. Using a modified “wick in needle” technique, interstitial fluid pressure (IFP) was measured in the flaps at various times up to 2 weeks postoperatively. Increases in IFP to positive values were seen by 12 hours. IFP remained elevated for 3 to 5 days, after which they gradually returned to control values by 2 weeks. This is the first study to follow the time course and magnitude of changes in IFP and edema in free flaps. It is a useful animal model by which the hemodynamic effects of physical and pharmacological manipulation of flaps can be studied.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>17975771</pmid><doi>10.1055/s-2007-992338</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-684X |
| ispartof | Journal of reconstructive microsurgery, 2007-08, Vol.23 (6), p.317-320 |
| issn | 0743-684X 1098-8947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70089631 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Abdomen - surgery Anastomosis, Surgical - methods Animals Biological and medical sciences Edema - physiopathology Extracellular Fluid - physiology Female Femoral Artery - surgery Femoral Nerve - surgery Femoral Vein - surgery General aspects Graft Survival Hemodynamics - physiology Medical sciences Microsurgery - methods Models, Animal Pressure Rats Rats, Sprague-Dawley Skin Transplantation - pathology Skin Transplantation - physiology Surgical Flaps - blood supply Surgical Flaps - physiology Suture Techniques Time Factors |
| title | Interstitial Fluid Pressure in Free Vascularized Skin Flaps of the Rat Epigastrium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T11%3A25%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interstitial%20Fluid%20Pressure%20in%20Free%20Vascularized%20Skin%20Flaps%20of%20the%20Rat%20Epigastrium&rft.jtitle=Journal%20of%20reconstructive%20microsurgery&rft.au=Davidson,%20John%20S.D&rft.date=2007-08-01&rft.volume=23&rft.issue=6&rft.spage=317&rft.epage=320&rft.pages=317-320&rft.issn=0743-684X&rft.eissn=1098-8947&rft.coden=JRMIE2&rft_id=info:doi/10.1055/s-2007-992338&rft_dat=%3Cproquest_cross%3E70089631%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70089631&rft_id=info:pmid/17975771&rfr_iscdi=true |