Retinoic acid signaling in myelopoiesis
PURPOSE OF REVIEWFor decades, retinoic acid has been known to alter the proliferation and differentiation of myeloid cells. Currently, retinoic acid is a front-line agent in the treatment of certain forms of acute myelogenous leukemia. In this review, we focus on recent advances in our understanding...
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| Veröffentlicht in: | Current opinion in hematology 2008-01, Vol.15 (1), p.37-41 |
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| creator | Drumea, Karen Yang, Zhong-fa Rosmarin, Alan |
| description | PURPOSE OF REVIEWFor decades, retinoic acid has been known to alter the proliferation and differentiation of myeloid cells. Currently, retinoic acid is a front-line agent in the treatment of certain forms of acute myelogenous leukemia. In this review, we focus on recent advances in our understanding of the mechanisms by which retinoids affect growth and proliferation of myeloid cells and contribute to the pathogenesis of leukemia. We have not attempted to summarize the related clinical literature.
RECENT FINDINGSThe past 2 years have yielded important understanding of the mechanisms by which retinoids and their nuclear receptors interact with other signal transduction pathways and transcription factors to modify chromatin, alter gene expression, and participate in normal myeloid differentiation and leukemogenesis. Important advances regarding cell biology, molecular biology, biochemistry, and animal studies of retinoids and myeloid differentiation are reviewed.
SUMMARYGreater understanding of the role of retinoids and their receptors in myeloid cell growth and differentiation provides important insight into normal myelopoiesis. These findings have resulted in successful rational approaches to the treatment of acute leukemia and provide the promise of improved treatments in the near future. |
| doi_str_mv | 10.1097/MOH.0b013e3282f20a9c |
| format | Article |
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RECENT FINDINGSThe past 2 years have yielded important understanding of the mechanisms by which retinoids and their nuclear receptors interact with other signal transduction pathways and transcription factors to modify chromatin, alter gene expression, and participate in normal myeloid differentiation and leukemogenesis. Important advances regarding cell biology, molecular biology, biochemistry, and animal studies of retinoids and myeloid differentiation are reviewed.
SUMMARYGreater understanding of the role of retinoids and their receptors in myeloid cell growth and differentiation provides important insight into normal myelopoiesis. These findings have resulted in successful rational approaches to the treatment of acute leukemia and provide the promise of improved treatments in the near future.</description><identifier>ISSN: 1065-6251</identifier><identifier>EISSN: 1531-7048</identifier><identifier>DOI: 10.1097/MOH.0b013e3282f20a9c</identifier><identifier>PMID: 18043244</identifier><identifier>CODEN: COHEF4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cell Transformation, Neoplastic ; Chromatin - genetics ; Chromatin - metabolism ; Gene Expression Regulation - physiology ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Myeloid - pathology ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Mice ; Myeloid Cells - cytology ; Myeloid Cells - drug effects ; Myelopoiesis - drug effects ; Myelopoiesis - physiology ; Myeloproliferative Disorders - pathology ; Oncogene Proteins, Fusion - metabolism ; Protein Processing, Post-Translational ; Receptors, Retinoic Acid - drug effects ; Receptors, Retinoic Acid - physiology ; Retinoids - physiology ; Signal Transduction ; Transcription Factors - metabolism ; Tretinoin - pharmacology ; Tretinoin - physiology ; Tretinoin - therapeutic use</subject><ispartof>Current opinion in hematology, 2008-01, Vol.15 (1), p.37-41</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3807-a3920d1f675c7d99ea7ceac083caf6e695054a8d89f9b84b49fcab84d8468d493</citedby><cites>FETCH-LOGICAL-c3807-a3920d1f675c7d99ea7ceac083caf6e695054a8d89f9b84b49fcab84d8468d493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19892935$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18043244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drumea, Karen</creatorcontrib><creatorcontrib>Yang, Zhong-fa</creatorcontrib><creatorcontrib>Rosmarin, Alan</creatorcontrib><title>Retinoic acid signaling in myelopoiesis</title><title>Current opinion in hematology</title><addtitle>Curr Opin Hematol</addtitle><description>PURPOSE OF REVIEWFor decades, retinoic acid has been known to alter the proliferation and differentiation of myeloid cells. Currently, retinoic acid is a front-line agent in the treatment of certain forms of acute myelogenous leukemia. In this review, we focus on recent advances in our understanding of the mechanisms by which retinoids affect growth and proliferation of myeloid cells and contribute to the pathogenesis of leukemia. We have not attempted to summarize the related clinical literature.
RECENT FINDINGSThe past 2 years have yielded important understanding of the mechanisms by which retinoids and their nuclear receptors interact with other signal transduction pathways and transcription factors to modify chromatin, alter gene expression, and participate in normal myeloid differentiation and leukemogenesis. Important advances regarding cell biology, molecular biology, biochemistry, and animal studies of retinoids and myeloid differentiation are reviewed.
SUMMARYGreater understanding of the role of retinoids and their receptors in myeloid cell growth and differentiation provides important insight into normal myelopoiesis. These findings have resulted in successful rational approaches to the treatment of acute leukemia and provide the promise of improved treatments in the near future.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Transformation, Neoplastic</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Gene Expression Regulation - physiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Myeloid Cells - cytology</subject><subject>Myeloid Cells - drug effects</subject><subject>Myelopoiesis - drug effects</subject><subject>Myelopoiesis - physiology</subject><subject>Myeloproliferative Disorders - pathology</subject><subject>Oncogene Proteins, Fusion - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>Receptors, Retinoic Acid - drug effects</subject><subject>Receptors, Retinoic Acid - physiology</subject><subject>Retinoids - physiology</subject><subject>Signal Transduction</subject><subject>Transcription Factors - metabolism</subject><subject>Tretinoin - pharmacology</subject><subject>Tretinoin - physiology</subject><subject>Tretinoin - therapeutic use</subject><issn>1065-6251</issn><issn>1531-7048</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9Lw0AQxRdRbK1-A5Fe1FPq7L_s7lGKWqFSED0vm82mXd0kNZtQ-u2NGih4GGYGfu_N8BC6xDDDoMTdy2oxgwwwdZRIUhAwyh6hMeYUJwKYPO5nSHmSEo5H6CzGDwBMFPBTNMISGCWMjdHtq2t9VXs7Ndbn0-jXlQm-Wk99NS33LtTb2rvo4zk6KUyI7mLoE_T--PA2XyTL1dPz_H6ZWCpBJIYqAjkuUsGtyJVyRlhnLEhqTZG6VHHgzMhcqkJlkmVMFdb0Qy5ZKnOm6ATd_Plum_qrc7HVpY_WhWAqV3dRCwAp01-Q_YG2qWNsXKG3jS9Ns9cY9E9Aug9I_w-ol10N_l1WuvwgGhLpgesBMNGaUDSmsj4eOCUVUZQf7u_q0LomfoZu5xq9cSa0Gw0AKRGcJKT_F3C_Jn2BoN9jGH4c</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Drumea, Karen</creator><creator>Yang, Zhong-fa</creator><creator>Rosmarin, Alan</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Retinoic acid signaling in myelopoiesis</title><author>Drumea, Karen ; Yang, Zhong-fa ; Rosmarin, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3807-a3920d1f675c7d99ea7ceac083caf6e695054a8d89f9b84b49fcab84d8468d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Transformation, Neoplastic</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>Gene Expression Regulation - physiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Myeloid - pathology</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Myeloid Cells - cytology</topic><topic>Myeloid Cells - drug effects</topic><topic>Myelopoiesis - drug effects</topic><topic>Myelopoiesis - physiology</topic><topic>Myeloproliferative Disorders - pathology</topic><topic>Oncogene Proteins, Fusion - metabolism</topic><topic>Protein Processing, Post-Translational</topic><topic>Receptors, Retinoic Acid - drug effects</topic><topic>Receptors, Retinoic Acid - physiology</topic><topic>Retinoids - physiology</topic><topic>Signal Transduction</topic><topic>Transcription Factors - metabolism</topic><topic>Tretinoin - pharmacology</topic><topic>Tretinoin - physiology</topic><topic>Tretinoin - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Drumea, Karen</creatorcontrib><creatorcontrib>Yang, Zhong-fa</creatorcontrib><creatorcontrib>Rosmarin, Alan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drumea, Karen</au><au>Yang, Zhong-fa</au><au>Rosmarin, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid signaling in myelopoiesis</atitle><jtitle>Current opinion in hematology</jtitle><addtitle>Curr Opin Hematol</addtitle><date>2008-01</date><risdate>2008</risdate><volume>15</volume><issue>1</issue><spage>37</spage><epage>41</epage><pages>37-41</pages><issn>1065-6251</issn><eissn>1531-7048</eissn><coden>COHEF4</coden><abstract>PURPOSE OF REVIEWFor decades, retinoic acid has been known to alter the proliferation and differentiation of myeloid cells. Currently, retinoic acid is a front-line agent in the treatment of certain forms of acute myelogenous leukemia. In this review, we focus on recent advances in our understanding of the mechanisms by which retinoids affect growth and proliferation of myeloid cells and contribute to the pathogenesis of leukemia. We have not attempted to summarize the related clinical literature.
RECENT FINDINGSThe past 2 years have yielded important understanding of the mechanisms by which retinoids and their nuclear receptors interact with other signal transduction pathways and transcription factors to modify chromatin, alter gene expression, and participate in normal myeloid differentiation and leukemogenesis. Important advances regarding cell biology, molecular biology, biochemistry, and animal studies of retinoids and myeloid differentiation are reviewed.
SUMMARYGreater understanding of the role of retinoids and their receptors in myeloid cell growth and differentiation provides important insight into normal myelopoiesis. These findings have resulted in successful rational approaches to the treatment of acute leukemia and provide the promise of improved treatments in the near future.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18043244</pmid><doi>10.1097/MOH.0b013e3282f20a9c</doi><tpages>5</tpages></addata></record> |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Biological and medical sciences Cell Differentiation - drug effects Cell Transformation, Neoplastic Chromatin - genetics Chromatin - metabolism Gene Expression Regulation - physiology Hematologic and hematopoietic diseases Humans Leukemia, Myeloid - pathology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Myeloid Cells - cytology Myeloid Cells - drug effects Myelopoiesis - drug effects Myelopoiesis - physiology Myeloproliferative Disorders - pathology Oncogene Proteins, Fusion - metabolism Protein Processing, Post-Translational Receptors, Retinoic Acid - drug effects Receptors, Retinoic Acid - physiology Retinoids - physiology Signal Transduction Transcription Factors - metabolism Tretinoin - pharmacology Tretinoin - physiology Tretinoin - therapeutic use |
| title | Retinoic acid signaling in myelopoiesis |
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