A novel series of highly selective inhibitors of MMP-3

The design and synthesis of a series of highly selective hydroxamate inhibitors of MMP-3 is described. Substitution of a 4-biaryl piperidine sulfonamide core was optimised to give potent inhibitors of MMP-3, with greater than 300-fold selectivity over MMP-1, MMP-2, MMP-9 and MMP-14. The design and s...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-12, Vol.17 (24), p.6750-6753
Hauptverfasser:	Whitlock, Gavin A., Dack, Kevin N., Dickinson, Roger P., Lewis, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Biological and medical sciences Combinatorial Chemistry Techniques Drug Delivery Systems Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Matrix Metalloproteinase Inhibitors Medical sciences MMP-3 Models, Molecular Molecular Structure Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Selectivity Skin, nail, hair, dermoskeleton Stromelysin Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Topical delivery Wound healing
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