Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions
Summary To determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and sur...
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| Veröffentlicht in: | Osteoporosis international 2008, Vol.19 (1), p.57-63 |
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| creator | Kelly, M. H. Brillante, B. Collins, M. T. |
| description | Summary
To determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and surprisingly severity did not correlate with skeletal disease burden.
Introduction
Pain is common in fibrous dysplasia (FD), but relatively unstudied. We studied a well-characterized population of patients with a spectrum of disease.
Methods
Thirty-five children (16 male, 19 female, mean age 11.4 (range 5–18)) and 43 adults (15 male, 28 female, 23–62 yrs, mean age 40.3 (range 23–62)) were studied. Bone scans were used to identify the location and extent of disease. The Brief Pain Inventory was used to determine severity.
Results
Pain at sites of FD was common, reported by 67% of the population, but more prevalent and severe in the adult group than the children (81% and 49%, respectively p |
| doi_str_mv | 10.1007/s00198-007-0425-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70086216</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70086216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-7ff769261a30483c052b67f88d4823a02d26933c440ee9bbf63a1cfca6e42a263</originalsourceid><addsrcrecordid>eNp1kduKFDEQhoMo7rj6AN5IEPQumtPk4N2yeIIFvVDwLlSnk92MPd1jqht23940MzAgCIEqUl9VKv9PyEvB3wnO7XvkXHjHWsq4llt2_4hshFaKSW-2j8mGe2WZ1-LXBXmGuOMN9N4-JRfCGim1tRuy-w5lpO3k0tVpQdo_4GEALECnTLtpTB8o3CZW0wBz6mm8g_E2IYWxp_NdahHmaV8iDLQvONfSLXOZxrUZf6chza0wJGxX-Jw8yTBgenGKl-Tnp48_rr-wm2-fv15f3bCotZyZzdkaL40AxbVTkW9lZ2x2rtdOKuCyl8Yr1WCeku-6bBSImCOYpCVIoy7J2-PcQ53-LAnnsC8Y0zDAmNoPg-XcGSlW8PU_4G5a6th2C1I4Z4S0KySOUKwTYk05HGrZQ30IgofVhXB0Iazp6kK4bz2vToOXbp_6c8dJ9ga8OQGATbpcYYwFz1xzySinGiePHLZS072eN_z_638BoR2f6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218861276</pqid></control><display><type>article</type><title>Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions</title><source>MEDLINE</source><source>Springer Journals</source><creator>Kelly, M. H. ; Brillante, B. ; Collins, M. T.</creator><creatorcontrib>Kelly, M. H. ; Brillante, B. ; Collins, M. T.</creatorcontrib><description>Summary
To determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and surprisingly severity did not correlate with skeletal disease burden.
Introduction
Pain is common in fibrous dysplasia (FD), but relatively unstudied. We studied a well-characterized population of patients with a spectrum of disease.
Methods
Thirty-five children (16 male, 19 female, mean age 11.4 (range 5–18)) and 43 adults (15 male, 28 female, 23–62 yrs, mean age 40.3 (range 23–62)) were studied. Bone scans were used to identify the location and extent of disease. The Brief Pain Inventory was used to determine severity.
Results
Pain at sites of FD was common, reported by 67% of the population, but more prevalent and severe in the adult group than the children (81% and 49%, respectively p < 0.005, severity 4.1/10, and 2.8/10, respectively, p < 0.01). Surprisingly, there was no correlation between pain severity and skeletal disease burden. Children were more likely than adults to be untreated for pain (44% vs. 26%).
Conclusions
Pain, which was sometimes severe, was common in subjects with FD. It was often un- or under-treated, especially in children. The prevalence and severity of pain was greater in the adult group, but unrelated to the burden of FD.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-007-0425-x</identifier><identifier>PMID: 17622477</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Age Factors ; Aging ; Anatomy & physiology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Bone diseases ; Child ; Child, Preschool ; Children & youth ; Diphosphonates - therapeutic use ; Diseases of the osteoarticular system ; Endocrinology ; Endocrinopathies ; Female ; Fibrous Dysplasia of Bone - complications ; Fibrous Dysplasia of Bone - epidemiology ; Humans ; Male ; Malformations and congenital and or hereditary diseases involving bones. Joint deformations ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Narcotics - therapeutic use ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Original Article ; Orthopedics ; Osteoporosis. Osteomalacia. Paget disease ; Pain ; Pain - drug therapy ; Pain - epidemiology ; Pain - etiology ; Pain Measurement ; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) ; Rheumatology</subject><ispartof>Osteoporosis international, 2008, Vol.19 (1), p.57-63</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2007</rights><rights>2008 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-7ff769261a30483c052b67f88d4823a02d26933c440ee9bbf63a1cfca6e42a263</citedby><cites>FETCH-LOGICAL-c442t-7ff769261a30483c052b67f88d4823a02d26933c440ee9bbf63a1cfca6e42a263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-007-0425-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-007-0425-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,4025,27928,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19976383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17622477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, M. H.</creatorcontrib><creatorcontrib>Brillante, B.</creatorcontrib><creatorcontrib>Collins, M. T.</creatorcontrib><title>Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
To determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and surprisingly severity did not correlate with skeletal disease burden.
Introduction
Pain is common in fibrous dysplasia (FD), but relatively unstudied. We studied a well-characterized population of patients with a spectrum of disease.
Methods
Thirty-five children (16 male, 19 female, mean age 11.4 (range 5–18)) and 43 adults (15 male, 28 female, 23–62 yrs, mean age 40.3 (range 23–62)) were studied. Bone scans were used to identify the location and extent of disease. The Brief Pain Inventory was used to determine severity.
Results
Pain at sites of FD was common, reported by 67% of the population, but more prevalent and severe in the adult group than the children (81% and 49%, respectively p < 0.005, severity 4.1/10, and 2.8/10, respectively, p < 0.01). Surprisingly, there was no correlation between pain severity and skeletal disease burden. Children were more likely than adults to be untreated for pain (44% vs. 26%).
Conclusions
Pain, which was sometimes severe, was common in subjects with FD. It was often un- or under-treated, especially in children. The prevalence and severity of pain was greater in the adult group, but unrelated to the burden of FD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Anatomy & physiology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bone diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Diphosphonates - therapeutic use</subject><subject>Diseases of the osteoarticular system</subject><subject>Endocrinology</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fibrous Dysplasia of Bone - complications</subject><subject>Fibrous Dysplasia of Bone - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Narcotics - therapeutic use</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - epidemiology</subject><subject>Pain - etiology</subject><subject>Pain Measurement</subject><subject>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</subject><subject>Rheumatology</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kduKFDEQhoMo7rj6AN5IEPQumtPk4N2yeIIFvVDwLlSnk92MPd1jqht23940MzAgCIEqUl9VKv9PyEvB3wnO7XvkXHjHWsq4llt2_4hshFaKSW-2j8mGe2WZ1-LXBXmGuOMN9N4-JRfCGim1tRuy-w5lpO3k0tVpQdo_4GEALECnTLtpTB8o3CZW0wBz6mm8g_E2IYWxp_NdahHmaV8iDLQvONfSLXOZxrUZf6chza0wJGxX-Jw8yTBgenGKl-Tnp48_rr-wm2-fv15f3bCotZyZzdkaL40AxbVTkW9lZ2x2rtdOKuCyl8Yr1WCeku-6bBSImCOYpCVIoy7J2-PcQ53-LAnnsC8Y0zDAmNoPg-XcGSlW8PU_4G5a6th2C1I4Z4S0KySOUKwTYk05HGrZQ30IgofVhXB0Iazp6kK4bz2vToOXbp_6c8dJ9ga8OQGATbpcYYwFz1xzySinGiePHLZS072eN_z_638BoR2f6w</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Kelly, M. H.</creator><creator>Brillante, B.</creator><creator>Collins, M. T.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions</title><author>Kelly, M. H. ; Brillante, B. ; Collins, M. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-7ff769261a30483c052b67f88d4823a02d26933c440ee9bbf63a1cfca6e42a263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Anatomy & physiology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bone diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Diphosphonates - therapeutic use</topic><topic>Diseases of the osteoarticular system</topic><topic>Endocrinology</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fibrous Dysplasia of Bone - complications</topic><topic>Fibrous Dysplasia of Bone - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Narcotics - therapeutic use</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain - epidemiology</topic><topic>Pain - etiology</topic><topic>Pain Measurement</topic><topic>Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelly, M. H.</creatorcontrib><creatorcontrib>Brillante, B.</creatorcontrib><creatorcontrib>Collins, M. T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelly, M. H.</au><au>Brillante, B.</au><au>Collins, M. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2008</date><risdate>2008</risdate><volume>19</volume><issue>1</issue><spage>57</spage><epage>63</epage><pages>57-63</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
To determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and surprisingly severity did not correlate with skeletal disease burden.
Introduction
Pain is common in fibrous dysplasia (FD), but relatively unstudied. We studied a well-characterized population of patients with a spectrum of disease.
Methods
Thirty-five children (16 male, 19 female, mean age 11.4 (range 5–18)) and 43 adults (15 male, 28 female, 23–62 yrs, mean age 40.3 (range 23–62)) were studied. Bone scans were used to identify the location and extent of disease. The Brief Pain Inventory was used to determine severity.
Results
Pain at sites of FD was common, reported by 67% of the population, but more prevalent and severe in the adult group than the children (81% and 49%, respectively p < 0.005, severity 4.1/10, and 2.8/10, respectively, p < 0.01). Surprisingly, there was no correlation between pain severity and skeletal disease burden. Children were more likely than adults to be untreated for pain (44% vs. 26%).
Conclusions
Pain, which was sometimes severe, was common in subjects with FD. It was often un- or under-treated, especially in children. The prevalence and severity of pain was greater in the adult group, but unrelated to the burden of FD.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>17622477</pmid><doi>10.1007/s00198-007-0425-x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Journals |
| subjects | Adolescent Adult Adults Age Age Factors Aging Anatomy & physiology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Bone diseases Child Child, Preschool Children & youth Diphosphonates - therapeutic use Diseases of the osteoarticular system Endocrinology Endocrinopathies Female Fibrous Dysplasia of Bone - complications Fibrous Dysplasia of Bone - epidemiology Humans Male Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Medicine Medicine & Public Health Middle Aged Narcotics - therapeutic use Non tumoral diseases. Target tissue resistance. Benign neoplasms Original Article Orthopedics Osteoporosis. Osteomalacia. Paget disease Pain Pain - drug therapy Pain - epidemiology Pain - etiology Pain Measurement Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Rheumatology |
| title | Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions |
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