Effect of beta-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture

Effect of beta-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture

We studied the effects of norepinephrine and beta1-adrenoblockers atenolol and metoprolol on the growth of neuritis in organotypic tissue culture of spinal ganglia from 10-12-day chicken embryos. Atenolol (10(-4) M) accelerated the growth of neurites in spinal ganglia by 45%, while metoprolol inhibi...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2007-05, Vol.143 (5), p.556-558
Hauptverfasser: Penniyainen, V A, Lopatina, E V, Tsyrlin, V A
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Sprache:eng
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Adrenergic beta-Antagonists - pharmacology
Animals
Atenolol - pharmacology
Chick Embryo
Dose-Response Relationship, Drug
Ganglia, Spinal - drug effects
Metoprolol - pharmacology
Neurites - drug effects
Tissue Culture Techniques
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container_title Bulletin of experimental biology and medicine
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creator Penniyainen, V A
Lopatina, E V
Tsyrlin, V A
description We studied the effects of norepinephrine and beta1-adrenoblockers atenolol and metoprolol on the growth of neuritis in organotypic tissue culture of spinal ganglia from 10-12-day chicken embryos. Atenolol (10(-4) M) accelerated the growth of neurites in spinal ganglia by 45%, while metoprolol inhibited the growth of the explants almost in all examined concentrations (10(-10)-10(-4) M). Thus, beta1-adrenoblockers can produce opposite effects on neurite growth. Both atenolol and metoprolol abolished the neurite-stimulating effect of norepinephrine, probably, because this effect is mediated via beta1-adrenoreceptors of spinal ganglia.
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subjects Adrenergic beta-Antagonists - pharmacology
Animals
Atenolol - pharmacology
Chick Embryo
Dose-Response Relationship, Drug
Ganglia, Spinal - drug effects
Metoprolol - pharmacology
Neurites - drug effects
Tissue Culture Techniques
title Effect of beta-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture
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