Early-onset of sporadic basal-cell carcinoma: germline mutations in the TP53, PTCH, and XPD genes

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in the Western world. The objective of this study was to examine together germline mutations in the TP53, PTCH, and XPD genes as risk factors for developing BCC at a young age. We hypothesized that mutations in these genes signif...

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Veröffentlicht in:	Puerto Rico health sciences journal 2007-12, Vol.26 (4), p.349-354
Hauptverfasser:	Suárez-Martínez, Edu B, Ruiz, Abigail, Matías, Jocelyn, Morales, Luisa, Cruz, Anayris, Vázquez, Deborah, Villa, Jaime, Matta, Jaime L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Carcinoma, Basal Cell - genetics Genes, p53 - genetics Germ-Line Mutation Humans Patched Receptors Patched-1 Receptor Receptors, Cell Surface - genetics Skin Neoplasms - genetics Time Factors Xeroderma Pigmentosum Group D Protein - genetics
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