T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction

Background The incidence of skin rashes or erythema multiforme to sulfamethoxazole in exposed patients is about 3%. Among patients with acquired immunodeficiency syndrome the risk is ≈ 10 times higher. The pathogenesis of these reactions and the reason for the increased frequency in HIV infections a...

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