ATM associates with and phosphorylates p53: mapping the region of interaction

The human genetic disorder ataxia-telangiectasia (AT) is characterized by immunodeficiency, progressive cerebellar ataxia, radiosensitivity, cell cycle checkpoint defects and cancer predisposition 1 . The gene mutated in this syndrome, ATM (for AT mutated), encodes a protein containing a phosphatidy...

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Veröffentlicht in:	Nature genetics 1998-12, Vol.20 (4), p.398-400
Hauptverfasser:	Khanna, Kum Kum, Keating, Katherine E., Kozlov, Sergei, Scott, Shaun, Gatei, Magtouf, Hobson, Karen, Taya, Yoichi, Gabrielli, Brian, Chan, Doug, Lees-Miller, Susan P., Lavin, Martin F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Ataxia Telangiectasia Mutated Proteins Binding Sites Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell Cycle Proteins Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) DNA-Binding Proteins Gene Function Human Genetics Humans letter Medical genetics Medical sciences Phosphorylation Protein Binding Protein-Serine-Threonine Kinases Proteins - chemistry Proteins - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins
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