The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners

SHIP2 (SH2‐containing inositol polyphosphate 5‐phosphatase 2) is a phosphatidylinositol (3,4,5)‐trisphosphate (PtdIns(3,4,5)P3) 5‐phosphatase containing various motifs susceptible to mediate protein‐protein interaction. In cell models, SHIP2 negatively regulates insulin signalling through its cataly...

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Veröffentlicht in:	Journal of cellular physiology 2008-01, Vol.214 (1), p.260-272
Hauptverfasser:	Onnockx, Sheela, De Schutter, Julie, Blockmans, Marianne, Xie, Jingwei, Jacobs, Christine, Vanderwinden, Jean-Marie, Erneux, Christophe, Pirson, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adipocytes - metabolism Amino Acid Substitution Animals Catalytic Domain Cell Line Cell Membrane - metabolism Cercopithecus aethiops CHO Cells COS Cells Cricetinae Cricetulus Fluorescein-5-isothiocyanate Fluorescent Antibody Technique, Direct Fluorescent Dyes Glutathione Transferase - metabolism Histidine - chemistry Humans Inositol Polyphosphate 5-Phosphatases Insulin - pharmacology Mice Myoblasts, Skeletal - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Precipitin Tests Protein Structure, Secondary Protein Structure, Tertiary Receptor, Insulin - metabolism Recombinant Fusion Proteins - metabolism Serine - metabolism Subcellular Fractions - metabolism Transfection Tryptophan - metabolism
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