Synthesis and evaluation of 11beta-substituted 21-chloro/iodo-(17alpha,20E/Z)-19-norpregna-1,3,5(10),20-te traene-3, 17beta-diols: high-affinity ligands for the estrogen receptor

We have synthesized six new estrogens substituted at the 11beta-position with a methoxy or vinyl group and at the 17alpha-position with an (E)- or (Z)-chloro/iodovinyl moiety. The products were obtained in good overall yields from the corresponding tri-n-butylstannylvinyl intermediates using the ele...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-11, Vol.41 (24), p.4686-4692
Hauptverfasser:	Hanson, R N, Napolitano, E, Fiaschi, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cytosol - metabolism Estradiol - analogs & derivatives Estradiol - chemical synthesis Estradiol - chemistry Estradiol - metabolism Female Ligands Receptors, Estrogen - metabolism Sheep Stereoisomerism Structure-Activity Relationship Uterus - metabolism Uterus - ultrastructure
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