Modulation of MDR1 and CYP3A Expression by Dexamethasone: Evidence for an Inverse Regulation in Adrenals

A strong overlap exists between gp170 and CYP3A substrates and inducers. In order to investigate a putative coregulation of MDR and CYPA gene expression, we measured their transcripts in human liver and after dexamethasone treatment in HepG2 cells or in different mouse tissues. In human liver, we ob...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-11, Vol.252 (2), p.392-395
Hauptverfasser:	Sérée, E., Villard, P.H., Hevér, A., Guigal, N., Puyoou, F., Charvet, B., Point-Scomma, H., Lechevalier, E., Lacarelle, B., Barra, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - metabolism Animals Aryl Hydrocarbon Hydroxylases ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis Base Sequence Cell Line Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Dexamethasone - pharmacology DNA Primers - genetics Enzyme Induction - drug effects Gene Expression - drug effects Genes, MDR - drug effects Humans In Vitro Techniques Liver - drug effects Liver - metabolism Mice Oxidoreductases, N-Demethylating - biosynthesis Oxidoreductases, N-Demethylating - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Distribution
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