Human GBF1 is a ubiquitously expressed gene of the Sec7 domain family mapping to 10q24
We present the cDNA sequence of human GBF1 along with data on expression pattern and genomic attributes. The deduced polypeptide encodes a putative guanine nucleotide exchange factor of 206.5 kDa, containing a centrally positioned Sec7 domain and a proline-rich region at the extreme C terminus. Its...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1998-12, Vol.54 (2), p.323-327 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | MANSOUR, S. J HERBRICK, J.-A SCHERER, S. W MELANCON, P |
| description | We present the cDNA sequence of human GBF1 along with data on expression pattern and genomic attributes. The deduced polypeptide encodes a putative guanine nucleotide exchange factor of 206.5 kDa, containing a centrally positioned Sec7 domain and a proline-rich region at the extreme C terminus. Its mRNA transcripts are found in 17 tissues and cell lines, likely suggesting a housekeeping role for GBF1p. The gene maps to 10q24, 2.33 cR from D10S540. It is fully contained within YAC 822C1 and covers at most 450 kb. Its Sec7 domain-encoding region harbors four introns. |
| doi_str_mv | 10.1006/geno.1998.5563 |
| format | Article |
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Its Sec7 domain-encoding region harbors four introns.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 10 - genetics</subject><subject>Cloning, Molecular</subject><subject>Exons - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - genetics</subject><subject>Genes. Genome</subject><subject>Guanine Nucleotide Exchange Factors</subject><subject>Humans</subject><subject>Introns - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Proteins - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtPwzAQBnALgUoprGxIHhBbii9-xB6hghapEgOPNXKSczHKq3Ei0f-eICJWphu-n77THSGXwJbAmLrdYd0swRi9lFLxIzIHpk2klVDHZM601lEiBT8lZyF8MsYM1_GMzIyONXA5J--bobI1Xd8_AvWBWjpkfj_4vhlCeaD41XYYAhZ0XIO0cbT_QPqCeUKLprK-ps5WfoSVbVtf72jfUGD7WJyTE2fLgBfTXJC3x4fX1SbaPq-fVnfbqI2V6iOUSsaAhimR8cxKyTQ4yIwUusjRYmwTAUwUjhUSueMKUDvj0GAuDALwBbn57W27Zj9g6NPKhxzL0tY4npAmjCVGgfoXQgIqFskPvJrgkFVYpG3nK9sd0uljY3495TbktnSdrXMf_tjYwmMm-TfanniG</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>MANSOUR, S. 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Genome</topic><topic>Guanine Nucleotide Exchange Factors</topic><topic>Humans</topic><topic>Introns - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Proteins - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MANSOUR, S. J</creatorcontrib><creatorcontrib>HERBRICK, J.-A</creatorcontrib><creatorcontrib>SCHERER, S. 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W</au><au>MELANCON, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human GBF1 is a ubiquitously expressed gene of the Sec7 domain family mapping to 10q24</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>54</volume><issue>2</issue><spage>323</spage><epage>327</epage><pages>323-327</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We present the cDNA sequence of human GBF1 along with data on expression pattern and genomic attributes. The deduced polypeptide encodes a putative guanine nucleotide exchange factor of 206.5 kDa, containing a centrally positioned Sec7 domain and a proline-rich region at the extreme C terminus. Its mRNA transcripts are found in 17 tissues and cell lines, likely suggesting a housekeeping role for GBF1p. The gene maps to 10q24, 2.33 cR from D10S540. It is fully contained within YAC 822C1 and covers at most 450 kb. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Base Sequence Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 10 - genetics Cloning, Molecular Exons - genetics Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Genes. Genome Guanine Nucleotide Exchange Factors Humans Introns - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Proteins - genetics RNA, Messenger - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid |
| title | Human GBF1 is a ubiquitously expressed gene of the Sec7 domain family mapping to 10q24 |
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