Neuropsychological dose effects of a freon, trifluoromethane (FC-23), compared to N2O
Animal studies show FC-23 to be a promising magnetic resonance imaging indicator of regional cerebral blood flow. In a Phase 1, dose ranging (investigative new drug) study, neuropsychological (NP) tests, subjective ratings, and intensive physiological monitoring were used to determine the maximum to...
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| Veröffentlicht in: | Neurotoxicology and teratology 1998-11, Vol.20 (6), p.617-626 |
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| container_title | Neurotoxicology and teratology |
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| creator | HAHILL, A. A BROWN, G. G FAGAN, S. C EWING, J. R BRANCH, C. A BALAKRISHNAN, G |
| description | Animal studies show FC-23 to be a promising magnetic resonance imaging indicator of regional cerebral blood flow. In a Phase 1, dose ranging (investigative new drug) study, neuropsychological (NP) tests, subjective ratings, and intensive physiological monitoring were used to determine the maximum tolerated concentration of FC-23 for human application. Five normal healthy male volunteers were exposed to concentrations of FC-23 between 10% and 60% [randomly interleaved with exposures to both room air and 40% nitrous oxide (N2O)] in a within-subjects, double-blind design. Analyses of individual cases and ranked group data showed that individuals tolerated the 30% concentration of FC-23 according to established criteria. Planned comparisons indicated that inhalation of FC-23 produced smaller NP changes and fewer negative symptoms than 40% N2O but poorer NP performance and more negative symptoms than room air. This study indicated that FC-23 is not inert and that humans do not tolerate concentrations suitable for current MRI technology. NP and subjective data assisted in characterizing the sedative effect of FC-23. |
| doi_str_mv | 10.1016/S0892-0362(98)00011-7 |
| format | Article |
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Planned comparisons indicated that inhalation of FC-23 produced smaller NP changes and fewer negative symptoms than 40% N2O but poorer NP performance and more negative symptoms than room air. This study indicated that FC-23 is not inert and that humans do not tolerate concentrations suitable for current MRI technology. 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A</creatorcontrib><creatorcontrib>BROWN, G. G</creatorcontrib><creatorcontrib>FAGAN, S. C</creatorcontrib><creatorcontrib>EWING, J. R</creatorcontrib><creatorcontrib>BRANCH, C. A</creatorcontrib><creatorcontrib>BALAKRISHNAN, G</creatorcontrib><title>Neuropsychological dose effects of a freon, trifluoromethane (FC-23), compared to N2O</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Animal studies show FC-23 to be a promising magnetic resonance imaging indicator of regional cerebral blood flow. In a Phase 1, dose ranging (investigative new drug) study, neuropsychological (NP) tests, subjective ratings, and intensive physiological monitoring were used to determine the maximum tolerated concentration of FC-23 for human application. Five normal healthy male volunteers were exposed to concentrations of FC-23 between 10% and 60% [randomly interleaved with exposures to both room air and 40% nitrous oxide (N2O)] in a within-subjects, double-blind design. Analyses of individual cases and ranked group data showed that individuals tolerated the 30% concentration of FC-23 according to established criteria. Planned comparisons indicated that inhalation of FC-23 produced smaller NP changes and fewer negative symptoms than 40% N2O but poorer NP performance and more negative symptoms than room air. This study indicated that FC-23 is not inert and that humans do not tolerate concentrations suitable for current MRI technology. NP and subjective data assisted in characterizing the sedative effect of FC-23.</description><subject>Adult</subject><subject>Affect - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chlorofluorocarbons, Methane - pharmacology</subject><subject>Cognition - drug effects</subject><subject>Contrast Media - pharmacology</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Neuropsychological Tests</subject><subject>Nitrous Oxide - pharmacology</subject><subject>Pharmacology. 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A ; BALAKRISHNAN, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-b0785a5337b865c7e00335cf116ed6bc59707865db097590054b2978f0170973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Affect - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chlorofluorocarbons, Methane - pharmacology</topic><topic>Cognition - drug effects</topic><topic>Contrast Media - pharmacology</topic><topic>Double-Blind Method</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Neuropsychological Tests</topic><topic>Nitrous Oxide - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAHILL, A. A</creatorcontrib><creatorcontrib>BROWN, G. G</creatorcontrib><creatorcontrib>FAGAN, S. C</creatorcontrib><creatorcontrib>EWING, J. R</creatorcontrib><creatorcontrib>BRANCH, C. A</creatorcontrib><creatorcontrib>BALAKRISHNAN, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAHILL, A. A</au><au>BROWN, G. G</au><au>FAGAN, S. C</au><au>EWING, J. R</au><au>BRANCH, C. A</au><au>BALAKRISHNAN, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological dose effects of a freon, trifluoromethane (FC-23), compared to N2O</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>20</volume><issue>6</issue><spage>617</spage><epage>626</epage><pages>617-626</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Animal studies show FC-23 to be a promising magnetic resonance imaging indicator of regional cerebral blood flow. In a Phase 1, dose ranging (investigative new drug) study, neuropsychological (NP) tests, subjective ratings, and intensive physiological monitoring were used to determine the maximum tolerated concentration of FC-23 for human application. Five normal healthy male volunteers were exposed to concentrations of FC-23 between 10% and 60% [randomly interleaved with exposures to both room air and 40% nitrous oxide (N2O)] in a within-subjects, double-blind design. Analyses of individual cases and ranked group data showed that individuals tolerated the 30% concentration of FC-23 according to established criteria. Planned comparisons indicated that inhalation of FC-23 produced smaller NP changes and fewer negative symptoms than 40% N2O but poorer NP performance and more negative symptoms than room air. This study indicated that FC-23 is not inert and that humans do not tolerate concentrations suitable for current MRI technology. NP and subjective data assisted in characterizing the sedative effect of FC-23.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>9831123</pmid><doi>10.1016/S0892-0362(98)00011-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Neurotoxicology and teratology, 1998-11, Vol.20 (6), p.617-626 |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Affect - drug effects Biological and medical sciences Chlorofluorocarbons, Methane - pharmacology Cognition - drug effects Contrast Media - pharmacology Double-Blind Method Drug toxicity and drugs side effects treatment Humans Magnetic Resonance Imaging - methods Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Neuropsychological Tests Nitrous Oxide - pharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects |
| title | Neuropsychological dose effects of a freon, trifluoromethane (FC-23), compared to N2O |
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