Overexpression of chicken interferon regulatory factor-1 (Ch-IRF-1) induces constitutive expression of MHC class I antigens but does not confer virus resistance to a permanent chicken fibroblast cell line

The chicken fibroblast cell line C32 has been transfected with the chicken homolog (Ch-IRF-1) of the mammalian transcription factor IRF-1. Stable transfectants were generated, constitutively overexpressing Ch-IRF-1 mRNA and protein. Cells overexpressing Ch-IRF-1 showed enhanced constitutive expressi...

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Veröffentlicht in:	Gene 1998-11, Vol.222 (2), p.269-278
Hauptverfasser:	Zoeller, B, Popp, M, Walter, A, Redmann-Müller, I, Lodemann, E, Jungwirth, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral effect b-f antigen beta-microglubulin binding proteins Carrier Proteins - genetics Cell Line Chickens disease resistance DNA, Complementary - genetics DNA-Binding Proteins - genetics fibroblasts Gene Expression gene overexpression Guanosine Monophosphate - metabolism gyanylate-binding protein histocompatibility antigens Histocompatibility Antigens Class I - genetics IFN-signal transduction Interferon Regulatory Factor-1 interferons major histocompatibility complex Mammals messenger RNA Newcastle disease virus Newcastle disease virus - immunology Phosphoproteins - genetics Sindbis virus Sindbis Virus - immunology transcription factors Transcriptional activator transcriptional activators Transfection Vaccinia virus Vaccinia virus - immunology Vesicular stomatitis Indiana virus - immunology Vesicular stomatitis virus Vesiculovirus
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