Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8
Background: Technetium Tc 99m hexamethyl propylene amine oxine ( 99mTc-HMPAO) has been used to radiolabel leukocytes with promising results for its clinical use in inflammatory bowel disease. During active ulcerative colitis, colonoscopy is indicated to determine the extent and the intensity of the...
Gespeichert in:
| Veröffentlicht in: | Gastrointestinal endoscopy 1998-11, Vol.48 (5), p.491-496 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 496 |
|---|---|
| container_issue | 5 |
| container_start_page | 491 |
| container_title | Gastrointestinal endoscopy |
| container_volume | 48 |
| creator | Guimbaud, Rosine Beades, Eric Chauvelot-Moachon, Laurence Quartier, Gilles Gaudric, Marianne Bertrand, Viviane Cellier, Christophe Vidon, Nicole Devaux, Jacques-Yves Richard, Bruno Couturier, Daniel Chaussade, Stanislas |
| description | Background: Technetium Tc 99m hexamethyl propylene amine oxine (
99mTc-HMPAO) has been used to radiolabel leukocytes with promising results for its clinical use in inflammatory bowel disease. During active ulcerative colitis, colonoscopy is indicated to determine the extent and the intensity of the disease for proper management. The aim of this prospective study was to determine whether
99mTc-HMPAO–labeled leukocyte scintigraphy can give information similar to that obtained with colonoscopy during acute attacks of ulcerative colitis.
Methods: Thirty-three consecutive patients with 50 acute episodes of ulcerative colitis underwent
99mTc-HMPAO scintigraphy and colonoscopy with biopsies. Scintigraphic determination of disease extent and intensity were compared with those obtained by colonoscopy with biopsies and clinico-biologic markers.
Results: The scintigraphic index of disease intensity was correlated with endoscopic index, Truelove index, biologic markers, and local release of interleukin-8. The extent measured by scintigraphy was well correlated to the endoscopic and histologic extent.
Conclusions:
99mTc-HMPAO scintigraphy accurately determines the extent and the intensity of acute ulcerative colitis lesions. This noninvasive method can specify the extent and the intensity of an acute attack in patients with previously known ulcerative colitis. (Gastrointest Endosc 1998;48:491-6.) |
| doi_str_mv | 10.1016/S0016-5107(98)70090-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70077353</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0016510798700902</els_id><sourcerecordid>70077353</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-9396edf3288fbbbf52f0d806ee164be7057499d05b5870c55a3695542b8db4463</originalsourceid><addsrcrecordid>eNqFUU1v1TAQjBBVeRR-QiUfEAKpKc6HY5sLQhVQpEoceJwtx9k0BscOtlOa_8qPqfPyVI5c1tbO7OxoJ8vOC3xZ4KJ59x2nmpMC0zecvaUYc5yXT7JdgTnNG0r502z3SHmWPQ_hJ8aYlVVxmp1yVhWsorvs7x7UYCHqeUR7hTgf0QD3coQ4LAZN3k2LAQtIjjpVd79WA_Mvp5YIKChto771choWpC2aZNRgY0B_dBzQbBT41LkDpJzRUYf36eM9mNR0diMpo61W0lygVjvjbrW6QGA7F5Sb1r-03So7bFhaEsEGHZcNMS6NoqQIMiR7_QH3q8Hkhr3ITnppArw8vmfZj8-f9lfX-c23L1-vPt7kqmI85rziDXR9VTLWt23bk7LHHcMNQNHULVBMaM15h0lLGMWKEFk1nJC6bFnX1nVTnWWvN910r98zhChGHRQYIy24OYgUDqUVqRKRbETlXQgeejF5PUq_iAKLNVVxSFWskQnOxCFVUaa58-OCuR2he5w6xpjwV0dchnSQ3kurdPgnTljT1CzRPmw0SMe40-BFChCsgk57UFF0Tv_HyAPASMQd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70077353</pqid></control><display><type>article</type><title>Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Guimbaud, Rosine ; Beades, Eric ; Chauvelot-Moachon, Laurence ; Quartier, Gilles ; Gaudric, Marianne ; Bertrand, Viviane ; Cellier, Christophe ; Vidon, Nicole ; Devaux, Jacques-Yves ; Richard, Bruno ; Couturier, Daniel ; Chaussade, Stanislas</creator><creatorcontrib>Guimbaud, Rosine ; Beades, Eric ; Chauvelot-Moachon, Laurence ; Quartier, Gilles ; Gaudric, Marianne ; Bertrand, Viviane ; Cellier, Christophe ; Vidon, Nicole ; Devaux, Jacques-Yves ; Richard, Bruno ; Couturier, Daniel ; Chaussade, Stanislas</creatorcontrib><description>Background: Technetium Tc 99m hexamethyl propylene amine oxine (
99mTc-HMPAO) has been used to radiolabel leukocytes with promising results for its clinical use in inflammatory bowel disease. During active ulcerative colitis, colonoscopy is indicated to determine the extent and the intensity of the disease for proper management. The aim of this prospective study was to determine whether
99mTc-HMPAO–labeled leukocyte scintigraphy can give information similar to that obtained with colonoscopy during acute attacks of ulcerative colitis.
Methods: Thirty-three consecutive patients with 50 acute episodes of ulcerative colitis underwent
99mTc-HMPAO scintigraphy and colonoscopy with biopsies. Scintigraphic determination of disease extent and intensity were compared with those obtained by colonoscopy with biopsies and clinico-biologic markers.
Results: The scintigraphic index of disease intensity was correlated with endoscopic index, Truelove index, biologic markers, and local release of interleukin-8. The extent measured by scintigraphy was well correlated to the endoscopic and histologic extent.
Conclusions:
99mTc-HMPAO scintigraphy accurately determines the extent and the intensity of acute ulcerative colitis lesions. This noninvasive method can specify the extent and the intensity of an acute attack in patients with previously known ulcerative colitis. (Gastrointest Endosc 1998;48:491-6.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/S0016-5107(98)70090-2</identifier><identifier>PMID: 9831837</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers ; Colitis, Ulcerative - diagnostic imaging ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - pathology ; Colonoscopy ; Digestion. Liver. Biliary tract. Spleen. Pancreas ; Digestive system. Abdomen ; Endoscopy ; Female ; Humans ; Interleukin-8 - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Leukocytes - diagnostic imaging ; Male ; Medical sciences ; Prospective Studies ; Radionuclide Imaging ; Radionuclide investigations ; Radiopharmaceuticals ; Sensitivity and Specificity ; Severity of Illness Index ; Technetium Tc 99m Exametazime</subject><ispartof>Gastrointestinal endoscopy, 1998-11, Vol.48 (5), p.491-496</ispartof><rights>1998 American Society for Gastrointestinal Endoscopy</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-9396edf3288fbbbf52f0d806ee164be7057499d05b5870c55a3695542b8db4463</citedby><cites>FETCH-LOGICAL-c389t-9396edf3288fbbbf52f0d806ee164be7057499d05b5870c55a3695542b8db4463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0016-5107(98)70090-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1586648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9831837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guimbaud, Rosine</creatorcontrib><creatorcontrib>Beades, Eric</creatorcontrib><creatorcontrib>Chauvelot-Moachon, Laurence</creatorcontrib><creatorcontrib>Quartier, Gilles</creatorcontrib><creatorcontrib>Gaudric, Marianne</creatorcontrib><creatorcontrib>Bertrand, Viviane</creatorcontrib><creatorcontrib>Cellier, Christophe</creatorcontrib><creatorcontrib>Vidon, Nicole</creatorcontrib><creatorcontrib>Devaux, Jacques-Yves</creatorcontrib><creatorcontrib>Richard, Bruno</creatorcontrib><creatorcontrib>Couturier, Daniel</creatorcontrib><creatorcontrib>Chaussade, Stanislas</creatorcontrib><title>Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: Technetium Tc 99m hexamethyl propylene amine oxine (
99mTc-HMPAO) has been used to radiolabel leukocytes with promising results for its clinical use in inflammatory bowel disease. During active ulcerative colitis, colonoscopy is indicated to determine the extent and the intensity of the disease for proper management. The aim of this prospective study was to determine whether
99mTc-HMPAO–labeled leukocyte scintigraphy can give information similar to that obtained with colonoscopy during acute attacks of ulcerative colitis.
Methods: Thirty-three consecutive patients with 50 acute episodes of ulcerative colitis underwent
99mTc-HMPAO scintigraphy and colonoscopy with biopsies. Scintigraphic determination of disease extent and intensity were compared with those obtained by colonoscopy with biopsies and clinico-biologic markers.
Results: The scintigraphic index of disease intensity was correlated with endoscopic index, Truelove index, biologic markers, and local release of interleukin-8. The extent measured by scintigraphy was well correlated to the endoscopic and histologic extent.
Conclusions:
99mTc-HMPAO scintigraphy accurately determines the extent and the intensity of acute ulcerative colitis lesions. This noninvasive method can specify the extent and the intensity of an acute attack in patients with previously known ulcerative colitis. (Gastrointest Endosc 1998;48:491-6.)</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Colitis, Ulcerative - diagnostic imaging</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colonoscopy</subject><subject>Digestion. Liver. Biliary tract. Spleen. Pancreas</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-8 - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukocytes - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Technetium Tc 99m Exametazime</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1TAQjBBVeRR-QiUfEAKpKc6HY5sLQhVQpEoceJwtx9k0BscOtlOa_8qPqfPyVI5c1tbO7OxoJ8vOC3xZ4KJ59x2nmpMC0zecvaUYc5yXT7JdgTnNG0r502z3SHmWPQ_hJ8aYlVVxmp1yVhWsorvs7x7UYCHqeUR7hTgf0QD3coQ4LAZN3k2LAQtIjjpVd79WA_Mvp5YIKChto771choWpC2aZNRgY0B_dBzQbBT41LkDpJzRUYf36eM9mNR0diMpo61W0lygVjvjbrW6QGA7F5Sb1r-03So7bFhaEsEGHZcNMS6NoqQIMiR7_QH3q8Hkhr3ITnppArw8vmfZj8-f9lfX-c23L1-vPt7kqmI85rziDXR9VTLWt23bk7LHHcMNQNHULVBMaM15h0lLGMWKEFk1nJC6bFnX1nVTnWWvN910r98zhChGHRQYIy24OYgUDqUVqRKRbETlXQgeejF5PUq_iAKLNVVxSFWskQnOxCFVUaa58-OCuR2he5w6xpjwV0dchnSQ3kurdPgnTljT1CzRPmw0SMe40-BFChCsgk57UFF0Tv_HyAPASMQd</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Guimbaud, Rosine</creator><creator>Beades, Eric</creator><creator>Chauvelot-Moachon, Laurence</creator><creator>Quartier, Gilles</creator><creator>Gaudric, Marianne</creator><creator>Bertrand, Viviane</creator><creator>Cellier, Christophe</creator><creator>Vidon, Nicole</creator><creator>Devaux, Jacques-Yves</creator><creator>Richard, Bruno</creator><creator>Couturier, Daniel</creator><creator>Chaussade, Stanislas</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8</title><author>Guimbaud, Rosine ; Beades, Eric ; Chauvelot-Moachon, Laurence ; Quartier, Gilles ; Gaudric, Marianne ; Bertrand, Viviane ; Cellier, Christophe ; Vidon, Nicole ; Devaux, Jacques-Yves ; Richard, Bruno ; Couturier, Daniel ; Chaussade, Stanislas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-9396edf3288fbbbf52f0d806ee164be7057499d05b5870c55a3695542b8db4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Colitis, Ulcerative - diagnostic imaging</topic><topic>Colitis, Ulcerative - metabolism</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colonoscopy</topic><topic>Digestion. Liver. Biliary tract. Spleen. Pancreas</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-8 - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukocytes - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Radiopharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Technetium Tc 99m Exametazime</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guimbaud, Rosine</creatorcontrib><creatorcontrib>Beades, Eric</creatorcontrib><creatorcontrib>Chauvelot-Moachon, Laurence</creatorcontrib><creatorcontrib>Quartier, Gilles</creatorcontrib><creatorcontrib>Gaudric, Marianne</creatorcontrib><creatorcontrib>Bertrand, Viviane</creatorcontrib><creatorcontrib>Cellier, Christophe</creatorcontrib><creatorcontrib>Vidon, Nicole</creatorcontrib><creatorcontrib>Devaux, Jacques-Yves</creatorcontrib><creatorcontrib>Richard, Bruno</creatorcontrib><creatorcontrib>Couturier, Daniel</creatorcontrib><creatorcontrib>Chaussade, Stanislas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guimbaud, Rosine</au><au>Beades, Eric</au><au>Chauvelot-Moachon, Laurence</au><au>Quartier, Gilles</au><au>Gaudric, Marianne</au><au>Bertrand, Viviane</au><au>Cellier, Christophe</au><au>Vidon, Nicole</au><au>Devaux, Jacques-Yves</au><au>Richard, Bruno</au><au>Couturier, Daniel</au><au>Chaussade, Stanislas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>48</volume><issue>5</issue><spage>491</spage><epage>496</epage><pages>491-496</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: Technetium Tc 99m hexamethyl propylene amine oxine (
99mTc-HMPAO) has been used to radiolabel leukocytes with promising results for its clinical use in inflammatory bowel disease. During active ulcerative colitis, colonoscopy is indicated to determine the extent and the intensity of the disease for proper management. The aim of this prospective study was to determine whether
99mTc-HMPAO–labeled leukocyte scintigraphy can give information similar to that obtained with colonoscopy during acute attacks of ulcerative colitis.
Methods: Thirty-three consecutive patients with 50 acute episodes of ulcerative colitis underwent
99mTc-HMPAO scintigraphy and colonoscopy with biopsies. Scintigraphic determination of disease extent and intensity were compared with those obtained by colonoscopy with biopsies and clinico-biologic markers.
Results: The scintigraphic index of disease intensity was correlated with endoscopic index, Truelove index, biologic markers, and local release of interleukin-8. The extent measured by scintigraphy was well correlated to the endoscopic and histologic extent.
Conclusions:
99mTc-HMPAO scintigraphy accurately determines the extent and the intensity of acute ulcerative colitis lesions. This noninvasive method can specify the extent and the intensity of an acute attack in patients with previously known ulcerative colitis. (Gastrointest Endosc 1998;48:491-6.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9831837</pmid><doi>10.1016/S0016-5107(98)70090-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-5107 |
| ispartof | Gastrointestinal endoscopy, 1998-11, Vol.48 (5), p.491-496 |
| issn | 0016-5107 1097-6779 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70077353 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Biological and medical sciences Biomarkers Colitis, Ulcerative - diagnostic imaging Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colonoscopy Digestion. Liver. Biliary tract. Spleen. Pancreas Digestive system. Abdomen Endoscopy Female Humans Interleukin-8 - metabolism Investigative techniques, diagnostic techniques (general aspects) Leukocytes - diagnostic imaging Male Medical sciences Prospective Studies Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals Sensitivity and Specificity Severity of Illness Index Technetium Tc 99m Exametazime |
| title | Technetium Tc 99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T14%3A43%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Technetium%20Tc%2099m%20hexamethyl%20propylene%20amine%20oxine%20leukocyte%20scintigraphy%20in%20patients%20with%20ulcerative%20colitis:%20correlation%20with%20clinical,%20biologic,%20endoscopic,%20and%20pathologic%20intensity,%20and%20local%20release%20of%20interleukin%208&rft.jtitle=Gastrointestinal%20endoscopy&rft.au=Guimbaud,%20Rosine&rft.date=1998-11-01&rft.volume=48&rft.issue=5&rft.spage=491&rft.epage=496&rft.pages=491-496&rft.issn=0016-5107&rft.eissn=1097-6779&rft.coden=GAENBQ&rft_id=info:doi/10.1016/S0016-5107(98)70090-2&rft_dat=%3Cproquest_cross%3E70077353%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70077353&rft_id=info:pmid/9831837&rft_els_id=S0016510798700902&rfr_iscdi=true |