Pseudotumour cerebri after varicella

Thrombotic complications in children with varicella are well known. Transient protein S deficiency due to the presence of an anti-protein S antibody seems to be responsible at least in part. In an 8-year-old girl, pseudotumour cerebri with abducens palsy and ileofemoral vein thrombosis occurred 3 we...

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Veröffentlicht in:European journal of pediatrics 1998-11, Vol.157 (11), p.904-906
Hauptverfasser: KONRAD, D, KUSTER, H, HUNZIKER, U. A
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container_title European journal of pediatrics
container_volume 157
creator KONRAD, D
KUSTER, H
HUNZIKER, U. A
description Thrombotic complications in children with varicella are well known. Transient protein S deficiency due to the presence of an anti-protein S antibody seems to be responsible at least in part. In an 8-year-old girl, pseudotumour cerebri with abducens palsy and ileofemoral vein thrombosis occurred 3 weeks after chickenpox. A transient elevation of anti-protein S auto-antibodies was identified. Under treatment with heparin the pseudotumour cerebri rapidly disappeared but the iliofemoral thrombosis persisted. Thrombotic complications after varicella might be mediated at least in part by antibodies against protein S. Early recognition of this condition permits appropriate treatment with recombinant tissue-type plasminogen activator.
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source MEDLINE; SpringerNature Journals
subjects Biological and medical sciences
Chickenpox - complications
Child
Female
Human viral diseases
Humans
Infectious diseases
Medical sciences
Protein S Deficiency - complications
Pseudotumor Cerebri - blood
Pseudotumor Cerebri - etiology
Venous Thrombosis - etiology
Viral diseases
Viral diseases of the nervous system
title Pseudotumour cerebri after varicella
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