1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase

A library of compounds were prepared by reacting 2-(bromomethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (5) with commercially available carboxylic acids in the presence of potassium carbonate or a tertiary amine base. From this library, (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N-[(phe...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-11, Vol.41 (24), p.4854-4860
Hauptverfasser:	Combrink, Keith D, Gülgeze, H. Belgin, Meanwell, Nicholas A, Pearce, Bradley C, Zulan, Pi, Bisacchi, Gregory S, Roberts, Daniel G. M, Stanley, Paul, Seiler, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Chymases Cyclic S-Oxides - chemical synthesis Cyclic S-Oxides - chemistry Cyclic S-Oxides - pharmacology Dermatitis, Contact - pathology Female Humans Hypersensitivity, Delayed - pathology Kinetics Mast Cells - enzymology Medical sciences Mice Pharmacology. Drug treatments Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Skin, nail, hair, dermoskeleton Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Tryptases
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