Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention
Intracranial aneurysms are common. 1 – 6 Autopsy studies have shown that the overall frequency in the general population ranges from 0.2 to 9.9 percent (mean frequency, approximately 5 percent), 5 , 6 suggesting that 10 to 15 million persons in the United States have or will have intracranial aneury...
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| Veröffentlicht in: | The New England journal of medicine 1998-12, Vol.339 (24), p.1725-1733 |
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| container_title | The New England journal of medicine |
| container_volume | 339 |
| creator | Wiebers, D Whisnant, J bes, G Meissner, I |
| description | Intracranial aneurysms are common.
1
–
6
Autopsy studies have shown that the overall frequency in the general population ranges from 0.2 to 9.9 percent (mean frequency, approximately 5 percent),
5
,
6
suggesting that 10 to 15 million persons in the United States have or will have intracranial aneurysms. These data, in combination with the incidence of aneurysmal subarachnoid hemorrhage (approximately 10 cases per 100,000 persons per year),
7
suggest that most intracranial aneurysms do not rupture.
The management of unruptured intracranial aneurysms is controversial
8
–
12
because of a lack of understanding of the natural history of these lesions and the risks of repairing . . . |
| doi_str_mv | 10.1056/NEJM199812103392401 |
| format | Article |
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1
–
6
Autopsy studies have shown that the overall frequency in the general population ranges from 0.2 to 9.9 percent (mean frequency, approximately 5 percent),
5
,
6
suggesting that 10 to 15 million persons in the United States have or will have intracranial aneurysms. These data, in combination with the incidence of aneurysmal subarachnoid hemorrhage (approximately 10 cases per 100,000 persons per year),
7
suggest that most intracranial aneurysms do not rupture.
The management of unruptured intracranial aneurysms is controversial
8
–
12
because of a lack of understanding of the natural history of these lesions and the risks of repairing . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199812103392401</identifier><identifier>PMID: 9867550</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aneurysm, Ruptured - epidemiology ; Aneurysm, Ruptured - etiology ; Aneurysms ; Biological and medical sciences ; Female ; Health care ; Hemorrhage ; Humans ; Intracranial Aneurysm - complications ; Intracranial Aneurysm - pathology ; Intracranial Aneurysm - surgery ; Male ; Medical sciences ; Middle Aged ; Neurology ; Probability ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Rupture, Spontaneous - epidemiology ; Subarachnoid Hemorrhage - epidemiology ; Subarachnoid Hemorrhage - etiology ; Vascular diseases and vascular malformations of the nervous system ; Vascular Surgical Procedures - adverse effects ; Vascular Surgical Procedures - mortality</subject><ispartof>The New England journal of medicine, 1998-12, Vol.339 (24), p.1725-1733</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-3846695e66a4690b3ba3f1ec695afea5055ae8114eb4e5e82fb1c0135d968f413</citedby><cites>FETCH-LOGICAL-c644t-3846695e66a4690b3ba3f1ec695afea5055ae8114eb4e5e82fb1c0135d968f413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199812103392401$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199812103392401$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1629294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9867550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiebers, D</creatorcontrib><creatorcontrib>Whisnant, J</creatorcontrib><creatorcontrib>bes, G</creatorcontrib><creatorcontrib>Meissner, I</creatorcontrib><creatorcontrib>The International Study of Unruptured Intracranial Aneurysms Investigators</creatorcontrib><creatorcontrib>International Study of Unruptured Intracranial Aneurysms Investigators</creatorcontrib><title>Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Intracranial aneurysms are common.
1
–
6
Autopsy studies have shown that the overall frequency in the general population ranges from 0.2 to 9.9 percent (mean frequency, approximately 5 percent),
5
,
6
suggesting that 10 to 15 million persons in the United States have or will have intracranial aneurysms. These data, in combination with the incidence of aneurysmal subarachnoid hemorrhage (approximately 10 cases per 100,000 persons per year),
7
suggest that most intracranial aneurysms do not rupture.
The management of unruptured intracranial aneurysms is controversial
8
–
12
because of a lack of understanding of the natural history of these lesions and the risks of repairing . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneurysm, Ruptured - epidemiology</subject><subject>Aneurysm, Ruptured - etiology</subject><subject>Aneurysms</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Health care</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Intracranial Aneurysm - complications</subject><subject>Intracranial Aneurysm - pathology</subject><subject>Intracranial Aneurysm - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Rupture, Spontaneous - epidemiology</subject><subject>Subarachnoid Hemorrhage - epidemiology</subject><subject>Subarachnoid Hemorrhage - etiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vascular Surgical Procedures - adverse effects</subject><subject>Vascular Surgical Procedures - mortality</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kM1Kw0AUhQdRaq0-gQhBxI1E578zy1KqVvyBasFdmKQ3ktpM6kwidOdD-IQ-iVNbFESczcC53zn3chDaJ_iUYCHPbgdXN0RrRSjBjGnKMdlAbSIYiznHchO1MaYq5l3NttGO91McHuG6hVpaya4QuI0ex9Y187pxMImGtnYmc8YWZhb1LDRu4Usffby9R6PCP0dVHo1WbGTs5EvzS_G-cU9FFjwhANwr2Lqo7C7ays3Mw97676Dx-eChfxlf310M-73rOJOc1zFTXEotQErDpcYpSw3LCWRBMzkYgYUwoAjhkHIQoGiekgwTJiZaqpwT1kHHq9y5q14a8HVSFj6D2cxYqBqfdDHuCqlpAA9_gdOqcTbcllDKNFeK8QCxFZS5ynsHeTJ3RWncIiE4WZae_FF6cB2so5u0hMm3Z91ymB-t58aHnvJQcVb4n2hJNdXL5ScrrCx9YmFa_rv0ExPZlbo</recordid><startdate>19981210</startdate><enddate>19981210</enddate><creator>Wiebers, D</creator><creator>Whisnant, J</creator><creator>bes, G</creator><creator>Meissner, I</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19981210</creationdate><title>Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention</title><author>Wiebers, D ; Whisnant, J ; bes, G ; Meissner, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-3846695e66a4690b3ba3f1ec695afea5055ae8114eb4e5e82fb1c0135d968f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneurysm, Ruptured - epidemiology</topic><topic>Aneurysm, Ruptured - etiology</topic><topic>Aneurysms</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Health care</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Intracranial Aneurysm - complications</topic><topic>Intracranial Aneurysm - pathology</topic><topic>Intracranial Aneurysm - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Probability</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Rupture, Spontaneous - epidemiology</topic><topic>Subarachnoid Hemorrhage - epidemiology</topic><topic>Subarachnoid Hemorrhage - etiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vascular Surgical Procedures - adverse effects</topic><topic>Vascular Surgical Procedures - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiebers, D</creatorcontrib><creatorcontrib>Whisnant, J</creatorcontrib><creatorcontrib>bes, G</creatorcontrib><creatorcontrib>Meissner, I</creatorcontrib><creatorcontrib>The International Study of Unruptured Intracranial Aneurysms Investigators</creatorcontrib><creatorcontrib>International Study of Unruptured Intracranial Aneurysms Investigators</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiebers, D</au><au>Whisnant, J</au><au>bes, G</au><au>Meissner, I</au><aucorp>The International Study of Unruptured Intracranial Aneurysms Investigators</aucorp><aucorp>International Study of Unruptured Intracranial Aneurysms Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1998-12-10</date><risdate>1998</risdate><volume>339</volume><issue>24</issue><spage>1725</spage><epage>1733</epage><pages>1725-1733</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Intracranial aneurysms are common.
1
–
6
Autopsy studies have shown that the overall frequency in the general population ranges from 0.2 to 9.9 percent (mean frequency, approximately 5 percent),
5
,
6
suggesting that 10 to 15 million persons in the United States have or will have intracranial aneurysms. These data, in combination with the incidence of aneurysmal subarachnoid hemorrhage (approximately 10 cases per 100,000 persons per year),
7
suggest that most intracranial aneurysms do not rupture.
The management of unruptured intracranial aneurysms is controversial
8
–
12
because of a lack of understanding of the natural history of these lesions and the risks of repairing . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9867550</pmid><doi>10.1056/NEJM199812103392401</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-12, Vol.339 (24), p.1725-1733 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70075692 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Aneurysm, Ruptured - epidemiology Aneurysm, Ruptured - etiology Aneurysms Biological and medical sciences Female Health care Hemorrhage Humans Intracranial Aneurysm - complications Intracranial Aneurysm - pathology Intracranial Aneurysm - surgery Male Medical sciences Middle Aged Neurology Probability Prospective Studies Retrospective Studies Risk Factors Rupture, Spontaneous - epidemiology Subarachnoid Hemorrhage - epidemiology Subarachnoid Hemorrhage - etiology Vascular diseases and vascular malformations of the nervous system Vascular Surgical Procedures - adverse effects Vascular Surgical Procedures - mortality |
| title | Unruptured Intracranial Aneurysms — Risk of Rupture and Risks of Surgical Intervention |
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