Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS
One-hundred twenty AIDS patients, tested by an optimized cytomegalovirus antigenemia (CMV-Ag) assay, were followed over a 6-month period in an attempt to correlate viral (CMV) load with severe CMV organ-specific disease. Among patients available for follow-up, CMV organ-specific disease was present...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 1998-10, Vol.32 (2), p.75-79 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Lipson, Steven M Match, Mark E I. Toro, Ana Kaplan, Mark H Shepp, David H |
| description | One-hundred twenty AIDS patients, tested by an optimized cytomegalovirus antigenemia (CMV-Ag) assay, were followed over a 6-month period in an attempt to correlate viral (CMV) load with severe CMV organ-specific disease. Among patients available for follow-up, CMV organ-specific disease was present in seven of eight (88%) with pp65 antigen levels ≥50 cells per 4 × 10
5 polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels |
| doi_str_mv | 10.1016/S0732-8893(98)00070-4 |
| format | Article |
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5 polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels <50 pp65 reactive cells did not develop CMV organ-specific disease within our 6-month follow-up period. The CMV-Ag assay, as standardized in our clinical setting, served as a marker and predictor of CMV organ-specific disease in our AIDS patient population.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/S0732-8893(98)00070-4</identifier><identifier>PMID: 9823528</identifier><identifier>CODEN: DMIDDZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>AIDS-Related Opportunistic Infections - diagnosis ; AIDS-Related Opportunistic Infections - virology ; AIDS/HIV ; Biological and medical sciences ; Cytomegalovirus - immunology ; Cytomegalovirus - isolation & purification ; Cytomegalovirus Infections - diagnosis ; Cytomegalovirus Infections - virology ; Cytopathogenic Effect, Viral ; Female ; Fluorescent Antibody Technique, Indirect ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Phosphoproteins - blood ; Polymerase Chain Reaction - methods ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virus Cultivation</subject><ispartof>Diagnostic microbiology and infectious disease, 1998-10, Vol.32 (2), p.75-79</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1a819f89c86e429c3102e4844204d5075df7efaa0e0a7176bca2f51b05587da83</citedby><cites>FETCH-LOGICAL-c389t-1a819f89c86e429c3102e4844204d5075df7efaa0e0a7176bca2f51b05587da83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0732-8893(98)00070-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1631368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9823528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipson, Steven M</creatorcontrib><creatorcontrib>Match, Mark E</creatorcontrib><creatorcontrib>I. Toro, Ana</creatorcontrib><creatorcontrib>Kaplan, Mark H</creatorcontrib><creatorcontrib>Shepp, David H</creatorcontrib><title>Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>One-hundred twenty AIDS patients, tested by an optimized cytomegalovirus antigenemia (CMV-Ag) assay, were followed over a 6-month period in an attempt to correlate viral (CMV) load with severe CMV organ-specific disease. Among patients available for follow-up, CMV organ-specific disease was present in seven of eight (88%) with pp65 antigen levels ≥50 cells per 4 × 10
5 polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels <50 pp65 reactive cells did not develop CMV organ-specific disease within our 6-month follow-up period. The CMV-Ag assay, as standardized in our clinical setting, served as a marker and predictor of CMV organ-specific disease in our AIDS patient population.</description><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>Cytomegalovirus Infections - virology</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phosphoproteins - blood</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Toro, Ana ; Kaplan, Mark H ; Shepp, David H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1a819f89c86e429c3102e4844204d5075df7efaa0e0a7176bca2f51b05587da83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>AIDS-Related Opportunistic Infections - virology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>Cytomegalovirus Infections - virology</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phosphoproteins - blood</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virus Cultivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipson, Steven M</creatorcontrib><creatorcontrib>Match, Mark E</creatorcontrib><creatorcontrib>I. Toro, Ana</creatorcontrib><creatorcontrib>Kaplan, Mark H</creatorcontrib><creatorcontrib>Shepp, David H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipson, Steven M</au><au>Match, Mark E</au><au>I. 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5 polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels <50 pp65 reactive cells did not develop CMV organ-specific disease within our 6-month follow-up period. The CMV-Ag assay, as standardized in our clinical setting, served as a marker and predictor of CMV organ-specific disease in our AIDS patient population.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9823528</pmid><doi>10.1016/S0732-8893(98)00070-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-8893 |
| ispartof | Diagnostic microbiology and infectious disease, 1998-10, Vol.32 (2), p.75-79 |
| issn | 0732-8893 1879-0070 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - virology AIDS/HIV Biological and medical sciences Cytomegalovirus - immunology Cytomegalovirus - isolation & purification Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - virology Cytopathogenic Effect, Viral Female Fluorescent Antibody Technique, Indirect Human viral diseases Humans Infectious diseases Male Medical sciences Phosphoproteins - blood Polymerase Chain Reaction - methods Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virus Cultivation |
| title | Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS |
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