Ontogeny of Local Sarcoplasmic Reticulum Ca2+ Signals in Cerebral Arteries: Ca2+ Sparks as Elementary Physiological Events

Ca release through ryanodine receptors (RyRs) in the sarcoplasmic reticulum is a key element of excitation-contraction coupling in muscle. In arterial smooth muscle, Ca release through RyRs activates Ca K (KCa) channels to oppose vasoconstriction. Local Ca transients ("Ca () sparks"), appa...

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Veröffentlicht in:	Circulation research 1998-11, Vol.83 (11), p.1104-1114
Hauptverfasser:	Gollasch, Maik, Wellman, George C, Knot, Harm J, Jaggar, Jonathan H, Damon, Deborah H, Bonev, Adrian D, Nelson, Mark T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Caffeine - pharmacology Calcium - metabolism Calcium Channels - biosynthesis Cell Division Cerebral Arteries - physiology Cerebral Arteries - ultrastructure Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Male Microscopy, Fluorescence Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Potassium Channels - biosynthesis Rats Rats, Sprague-Dawley Ryanodine Receptor Calcium Release Channel - biosynthesis Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - physiology Sarcoplasmic Reticulum - physiology Signal Transduction Vasoconstriction - physiology Vertebrates: nervous system and sense organs
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