Mast Cells Express Novel CD8 Molecules That Selectively Modulate Mediator Secretion

CD8, a marker largely restricted to subsets of T lymphocytes and NK cells, was detected on freshly isolated rat peritoneal mast cells (PMC). Using flow cytometry, Percoll-enriched rat PMC (> or = 98% purity) were positive for the hinge region of CD8alpha (67.5 +/- 9.5%; Ab OX8) and CD8beta (27.8...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-12, Vol.161 (11), p.6265-6272
Hauptverfasser:	Lin, Tong-Jun, Hirji, Nadir, Nohara, Osamu, Stenton, Grant R, Gilchrist, Mark, Befus, A. Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8 Antigens - biosynthesis CD8 Antigens - genetics CD8 Antigens - physiology Flow Cytometry Histamine Release - immunology Inflammation Mediators - metabolism Male Mast Cells - immunology Mast Cells - metabolism Mast Cells - secretion Microscopy, Confocal Nitric Oxide - biosynthesis Peritoneal Cavity - cytology Rats Rats, Sprague-Dawley Receptors, IgE - physiology Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha - biosynthesis
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