Type 2 Immune Deviation Has Differential Effects on Alloreactive CD4+ and CD8+ T Cells

Allograft rejection has been associated with detection of the type 1 lymphokines, IFN-gamma and IL-2. The role of type 2 cytokines (IL-4 and IL-5) remains controversial, as is whether alloreactive CD4+ and CD8+ T cells behave similarly when exposed to type 2 cytokine-enhancing manipulations. We stud...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (10), p.5236-5244
Hauptverfasser:	Matesic, Damir, Valujskikh, Anna, Pearlman, Eric, Higgins, Alan W, Gilliam, Anita C, Heeger, Peter S
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - secretion CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - secretion Cell Separation Cells, Cultured Cytokines - biosynthesis Cytokines - secretion Epitopes, T-Lymphocyte - immunology Female Graft Rejection - immunology Graft Rejection - pathology Immunization Interleukin-2 - biosynthesis Isoantigens - immunology Lymphocyte Activation - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, SCID Skin Transplantation - immunology Skin Transplantation - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - secretion Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism Transplantation, Homologous
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