α-Melanocyte-stimulating Hormone Signaling Regulates Expression of microphthalmia, a Gene Deficient in Waardenburg Syndrome

The pituitary peptide α-melanocyte-stimulating hormone (α-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically. One consequence of α-MSH stimulation is increased melanization attributable to induction of pigmentation enzymes, inc...

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Veröffentlicht in:	The Journal of biological chemistry 1998-12, Vol.273 (49), p.33042-33047
Hauptverfasser:	Price, E. Roydon, Horstmann, Martin A., Wells, Audrey G., Weilbaecher, Kathy N., Takemoto, Cliff M., Landis, Marc W., Fisher, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - metabolism Animals Cell Line Cricetinae Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - genetics Gene Expression Regulation Humans Microphthalmia-Associated Transcription Factor Phosphorylation Promoter Regions, Genetic Signal Transduction Transcription Factors Waardenburg Syndrome - genetics Waardenburg Syndrome - metabolism
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