Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome
Objective. To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS). Methods. Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters we...
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| Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2007-12, Vol.8 (4), p.181-189 |
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| creator | Milionis, Haralampos J Kostapanos, Michael S Vakalis, Konstantinos Theodorou, Ioanna Bouba, Ioanna Kalaitzidis, Rigas Georgiou, Ioannis Elisaf, Moses S Siamopoulos, Kostas C |
| description | Objective. To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS).
Methods. Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg.
Results. Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS.The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors.
Conclusions. RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies. |
| doi_str_mv | 10.3317/jraas.2007.027 |
| format | Article |
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Methods. Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg.
Results. Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS.The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors.
Conclusions. RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies.</description><identifier>ISSN: 1470-3203</identifier><identifier>EISSN: 1752-8976</identifier><identifier>DOI: 10.3317/jraas.2007.027</identifier><identifier>PMID: 18205097</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Demography ; Female ; Genotype ; Greece - epidemiology ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - genetics ; Male ; Metabolic Syndrome - complications ; Metabolic Syndrome - drug therapy ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - genetics ; Middle Aged ; Polymorphism, Genetic ; Prevalence ; Regression Analysis ; Renin-Angiotensin System - genetics ; Treatment Outcome</subject><ispartof>Journal of the renin-angiotensin-aldosterone system, 2007-12, Vol.8 (4), p.181-189</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-4e379fb7f51b4ff07a521d99909bd57179caa15ee32011a00a8c404fd6a3d94b3</citedby><cites>FETCH-LOGICAL-c369t-4e379fb7f51b4ff07a521d99909bd57179caa15ee32011a00a8c404fd6a3d94b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18205097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milionis, Haralampos J</creatorcontrib><creatorcontrib>Kostapanos, Michael S</creatorcontrib><creatorcontrib>Vakalis, Konstantinos</creatorcontrib><creatorcontrib>Theodorou, Ioanna</creatorcontrib><creatorcontrib>Bouba, Ioanna</creatorcontrib><creatorcontrib>Kalaitzidis, Rigas</creatorcontrib><creatorcontrib>Georgiou, Ioannis</creatorcontrib><creatorcontrib>Elisaf, Moses S</creatorcontrib><creatorcontrib>Siamopoulos, Kostas C</creatorcontrib><title>Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome</title><title>Journal of the renin-angiotensin-aldosterone system</title><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><description>Objective. To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS).
Methods. Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg.
Results. Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS.The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors.
Conclusions. RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies.</description><subject>Demography</subject><subject>Female</subject><subject>Genotype</subject><subject>Greece - epidemiology</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - drug therapy</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Prevalence</subject><subject>Regression Analysis</subject><subject>Renin-Angiotensin System - genetics</subject><subject>Treatment Outcome</subject><issn>1470-3203</issn><issn>1752-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1DAQhS0EoqXlyhH5xKXKMo6d9fqIKiiVKnGhZ2uSTHazSuzg8QrtmT-Ot7sSJ05-st77pPmE-KBgpbWyn_cJkVc1gF1BbV-Ja2Wbuto4u35dsrFQ6Rr0lXjHvAfQG2Pqt-JKbWpowNlr8edxXrDLMg4yURhDhWE7xkyBT3nqI2dKMZDkY0mz3FIgljHIvCOZE2GeKeSy5SUGphNnwTyWP5a_x7yTu-NC6YVXRhh6OVPGNk5jV5ChT3GmW_FmwInp_eW9Ec_fvv68_149_Xh4vP_yVHV67XJlSFs3tHZoVGuGASw2teqdc-DavrHKug5RNUTlYqUQADedATP0a9S9M62-EZ_O3CXFXwfi7OeRO5omDBQP7G2xaLSGUlydi12KzIkGv6RxxnT0CvxJu3_R7k_afdFeBh8v5EM7U_-vfvFcCnfnAuOW_D4eUiiX_g_3F5d7kHc</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Milionis, Haralampos J</creator><creator>Kostapanos, Michael S</creator><creator>Vakalis, Konstantinos</creator><creator>Theodorou, Ioanna</creator><creator>Bouba, Ioanna</creator><creator>Kalaitzidis, Rigas</creator><creator>Georgiou, Ioannis</creator><creator>Elisaf, Moses S</creator><creator>Siamopoulos, Kostas C</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome</title><author>Milionis, Haralampos J ; Kostapanos, Michael S ; Vakalis, Konstantinos ; Theodorou, Ioanna ; Bouba, Ioanna ; Kalaitzidis, Rigas ; Georgiou, Ioannis ; Elisaf, Moses S ; Siamopoulos, Kostas C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-4e379fb7f51b4ff07a521d99909bd57179caa15ee32011a00a8c404fd6a3d94b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Demography</topic><topic>Female</topic><topic>Genotype</topic><topic>Greece - epidemiology</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - drug therapy</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - genetics</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Prevalence</topic><topic>Regression Analysis</topic><topic>Renin-Angiotensin System - genetics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milionis, Haralampos J</creatorcontrib><creatorcontrib>Kostapanos, Michael S</creatorcontrib><creatorcontrib>Vakalis, Konstantinos</creatorcontrib><creatorcontrib>Theodorou, Ioanna</creatorcontrib><creatorcontrib>Bouba, Ioanna</creatorcontrib><creatorcontrib>Kalaitzidis, Rigas</creatorcontrib><creatorcontrib>Georgiou, Ioannis</creatorcontrib><creatorcontrib>Elisaf, Moses S</creatorcontrib><creatorcontrib>Siamopoulos, Kostas C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milionis, Haralampos J</au><au>Kostapanos, Michael S</au><au>Vakalis, Konstantinos</au><au>Theodorou, Ioanna</au><au>Bouba, Ioanna</au><au>Kalaitzidis, Rigas</au><au>Georgiou, Ioannis</au><au>Elisaf, Moses S</au><au>Siamopoulos, Kostas C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome</atitle><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><date>2007-12</date><risdate>2007</risdate><volume>8</volume><issue>4</issue><spage>181</spage><epage>189</epage><pages>181-189</pages><issn>1470-3203</issn><eissn>1752-8976</eissn><abstract>Objective. To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS).
Methods. Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg.
Results. Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS.The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors.
Conclusions. RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>18205097</pmid><doi>10.3317/jraas.2007.027</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Demography Female Genotype Greece - epidemiology Humans Hypertension - complications Hypertension - drug therapy Hypertension - genetics Male Metabolic Syndrome - complications Metabolic Syndrome - drug therapy Metabolic Syndrome - epidemiology Metabolic Syndrome - genetics Middle Aged Polymorphism, Genetic Prevalence Regression Analysis Renin-Angiotensin System - genetics Treatment Outcome |
| title | Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome |
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