Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis : a pilot study
To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis...
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| Veröffentlicht in: | Rheumatology international 1998, Vol.18 (3), p.113-118 |
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| creator | NAGASHIMA, M YOSHINO, S TANAKA, H YOSHIDA, N KASHIWAGI, N SANIABADI, A. R |
| description | To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 column) is an extracorporeal type device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. Patients received apheresis of 1 hr duration twice per week, 8 times over a period of 4 weeks. To prepare CD15+CD16- cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16- cells in patients with high bone marrow CD15+CD16- cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P < 0.001), tender joint count (P < 0.001) and duration of morning stiffness (P < 0.005). The results suggest that granulocytes and monocytes/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA. |
| doi_str_mv | 10.1007/s002960050068 |
| format | Article |
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R</creator><creatorcontrib>NAGASHIMA, M ; YOSHINO, S ; TANAKA, H ; YOSHIDA, N ; KASHIWAGI, N ; SANIABADI, A. R</creatorcontrib><description>To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 column) is an extracorporeal type device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. Patients received apheresis of 1 hr duration twice per week, 8 times over a period of 4 weeks. To prepare CD15+CD16- cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16- cells in patients with high bone marrow CD15+CD16- cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P < 0.001), tender joint count (P < 0.001) and duration of morning stiffness (P < 0.005). The results suggest that granulocytes and monocytes/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s002960050068</identifier><identifier>PMID: 9833252</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - therapy ; Biological and medical sciences ; Blood Transfusion, Autologous ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone marrow ; Cytokines - metabolism ; Female ; Flow Cytometry ; Granulocytes ; Humans ; Leukapheresis ; Leukocyte Count ; Leukocyte Transfusion ; Lewis X Antigen - metabolism ; Male ; Medical sciences ; Middle Aged ; Monocytes ; Pilot Projects ; Receptors, IgG - metabolism ; Rheumatoid arthritis ; Rheumatoid Factor - metabolism ; Studies ; Transfusions. Complications. Transfusion reactions. 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R</creatorcontrib><title>Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis : a pilot study</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><description>To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16- cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 column) is an extracorporeal type device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. Patients received apheresis of 1 hr duration twice per week, 8 times over a period of 4 weeks. To prepare CD15+CD16- cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16- cells in patients with high bone marrow CD15+CD16- cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P < 0.001), tender joint count (P < 0.001) and duration of morning stiffness (P < 0.005). The results suggest that granulocytes and monocytes/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion, Autologous</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone marrow</subject><subject>Cytokines - metabolism</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Granulocytes</subject><subject>Humans</subject><subject>Leukapheresis</subject><subject>Leukocyte Count</subject><subject>Leukocyte Transfusion</subject><subject>Lewis X Antigen - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Pilot Projects</subject><subject>Receptors, IgG - metabolism</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid Factor - metabolism</subject><subject>Studies</subject><subject>Transfusions. Complications. Transfusion reactions. 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R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-19da71c036648f6e49a9c54a860bda623981246e452b30b7fa435fd9902296903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion, Autologous</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone marrow</topic><topic>Cytokines - metabolism</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Granulocytes</topic><topic>Humans</topic><topic>Leukapheresis</topic><topic>Leukocyte Count</topic><topic>Leukocyte Transfusion</topic><topic>Lewis X Antigen - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Pilot Projects</topic><topic>Receptors, IgG - metabolism</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid Factor - metabolism</topic><topic>Studies</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGASHIMA, M</creatorcontrib><creatorcontrib>YOSHINO, S</creatorcontrib><creatorcontrib>TANAKA, H</creatorcontrib><creatorcontrib>YOSHIDA, N</creatorcontrib><creatorcontrib>KASHIWAGI, N</creatorcontrib><creatorcontrib>SANIABADI, A. 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To prepare CD15+CD16- cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16- cells in patients with high bone marrow CD15+CD16- cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P < 0.001), tender joint count (P < 0.001) and duration of morning stiffness (P < 0.005). The results suggest that granulocytes and monocytes/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9833252</pmid><doi>10.1007/s002960050068</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - therapy Biological and medical sciences Blood Transfusion, Autologous Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow Cytokines - metabolism Female Flow Cytometry Granulocytes Humans Leukapheresis Leukocyte Count Leukocyte Transfusion Lewis X Antigen - metabolism Male Medical sciences Middle Aged Monocytes Pilot Projects Receptors, IgG - metabolism Rheumatoid arthritis Rheumatoid Factor - metabolism Studies Transfusions. Complications. Transfusion reactions. Cell and gene therapy Treatment Outcome |
| title | Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis : a pilot study |
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