A Metastasizing Model of Anaplastic Human Wilms Tumor in the Nude Mouse
Abstract Reproducible animal models of Wilms tumor have been difficult to establish. We describe a model in which cells, banked from a patient with metastatic Wilms tumor, were implanted into nude mice, resulting in the development of primary renal and metastatic pulmonary lesions. Pathologically, t...
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| Veröffentlicht in: | European journal of pediatric surgery 1998-10, Vol.8 (5), p.295-298 |
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| container_title | European journal of pediatric surgery |
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| creator | Marvin, M. R. Kayton, M. L. O'Toole, Kathleen M. Rowe, Dorothy H. DeRosa, Carolyn Kindred, Amanda Trokhan, S. Chabot, J. Kandel, Jessica J. |
| description | Abstract
Reproducible animal models of Wilms tumor have been difficult to establish. We describe a model in which cells, banked from a patient with metastatic Wilms tumor, were implanted into nude mice, resulting in the development of primary renal and metastatic pulmonary lesions. Pathologically, the lesions resembled the blastemal component of anaplastic Wilms tumor. Primary tumors showed a significant propensity for growth in the kidney as opposed to other organs. Pulmonary metastases, histologically similar to the primary lesions, were regularly observed. This represents the first reproducible model of anaplastic, metastasizing human Wilms tumor. This system may prove effective for the study of factors influencing growth and angiogenesis in aggressive variants of Wilms tumor. |
| doi_str_mv | 10.1055/s-2008-1071217 |
| format | Article |
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Reproducible animal models of Wilms tumor have been difficult to establish. We describe a model in which cells, banked from a patient with metastatic Wilms tumor, were implanted into nude mice, resulting in the development of primary renal and metastatic pulmonary lesions. Pathologically, the lesions resembled the blastemal component of anaplastic Wilms tumor. Primary tumors showed a significant propensity for growth in the kidney as opposed to other organs. Pulmonary metastases, histologically similar to the primary lesions, were regularly observed. This represents the first reproducible model of anaplastic, metastasizing human Wilms tumor. This system may prove effective for the study of factors influencing growth and angiogenesis in aggressive variants of Wilms tumor.</description><identifier>ISSN: 0939-7248</identifier><identifier>EISSN: 1439-359X</identifier><identifier>DOI: 10.1055/s-2008-1071217</identifier><identifier>PMID: 9825240</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Anaplasia ; Animals ; Biological and medical sciences ; Disease Models, Animal ; Female ; Humans ; Kidney Neoplasms - pathology ; Kidneys ; Medical sciences ; Mice ; Mice, Nude ; Neoplasm Metastasis ; Nephrology. Urinary tract diseases ; Original article ; Tumors of the urinary system ; Wilms Tumor - pathology ; Wilms Tumor - secondary</subject><ispartof>European journal of pediatric surgery, 1998-10, Vol.8 (5), p.295-298</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-a59a3d097bfd4ceb7ca4504dcee3ff18425e81c7923eb970da4e7b43eb5616c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2008-1071217.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>309,310,314,776,780,785,786,3004,3005,23909,23910,25118,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1601991$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9825240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marvin, M. R.</creatorcontrib><creatorcontrib>Kayton, M. L.</creatorcontrib><creatorcontrib>O'Toole, Kathleen M.</creatorcontrib><creatorcontrib>Rowe, Dorothy H.</creatorcontrib><creatorcontrib>DeRosa, Carolyn</creatorcontrib><creatorcontrib>Kindred, Amanda</creatorcontrib><creatorcontrib>Trokhan, S.</creatorcontrib><creatorcontrib>Chabot, J.</creatorcontrib><creatorcontrib>Kandel, Jessica J.</creatorcontrib><title>A Metastasizing Model of Anaplastic Human Wilms Tumor in the Nude Mouse</title><title>European journal of pediatric surgery</title><addtitle>Eur J Pediatr Surg</addtitle><description>Abstract
Reproducible animal models of Wilms tumor have been difficult to establish. We describe a model in which cells, banked from a patient with metastatic Wilms tumor, were implanted into nude mice, resulting in the development of primary renal and metastatic pulmonary lesions. Pathologically, the lesions resembled the blastemal component of anaplastic Wilms tumor. Primary tumors showed a significant propensity for growth in the kidney as opposed to other organs. Pulmonary metastases, histologically similar to the primary lesions, were regularly observed. This represents the first reproducible model of anaplastic, metastasizing human Wilms tumor. This system may prove effective for the study of factors influencing growth and angiogenesis in aggressive variants of Wilms tumor.</description><subject>Anaplasia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Metastasis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Original article</subject><subject>Tumors of the urinary system</subject><subject>Wilms Tumor - pathology</subject><subject>Wilms Tumor - secondary</subject><issn>0939-7248</issn><issn>1439-359X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LwzAYh4MoOj-u3oQcxFv1TZoszXEM3YSpl4neQpq-1Ug_ZtMe9K83Y0VPQiAJv-f9JTyEnDO4ZiDlTUg4QJYwUIwztUcmTKQ6SaV-3ScT0PGsuMiOyHEIHwBMaA6H5FBnXHIBE7KY0QfsbYjLf_vmjT60BVa0LemssZsqBt7R5VDbhr74qg50PdRtR31D-3ekj0OBcWIIeEoOSlsFPBv3E_J8d7ueL5PV0-J-PlslLpWqT6zUNi1Aq7wshMNcOSskiMIhpmXJMsElZswpzVPMtYLCClS5iBc5ZVMH6Qm52vVuuvZzwNCb2geHVWUbjP8wCkDxjPMIXu9A17UhdFiaTedr230ZBmZrzgSzNWdGc3HgYmwe8hqLX3xUFfPLMbfB2arsbON8-GudAtOaRSzZYf27xxrNRzt0TTTy37M_8ESC5A</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Marvin, M. R.</creator><creator>Kayton, M. L.</creator><creator>O'Toole, Kathleen M.</creator><creator>Rowe, Dorothy H.</creator><creator>DeRosa, Carolyn</creator><creator>Kindred, Amanda</creator><creator>Trokhan, S.</creator><creator>Chabot, J.</creator><creator>Kandel, Jessica J.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>A Metastasizing Model of Anaplastic Human Wilms Tumor in the Nude Mouse</title><author>Marvin, M. R. ; Kayton, M. L. ; O'Toole, Kathleen M. ; Rowe, Dorothy H. ; DeRosa, Carolyn ; Kindred, Amanda ; Trokhan, S. ; Chabot, J. ; Kandel, Jessica J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-a59a3d097bfd4ceb7ca4504dcee3ff18425e81c7923eb970da4e7b43eb5616c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anaplasia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Metastasis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Original article</topic><topic>Tumors of the urinary system</topic><topic>Wilms Tumor - pathology</topic><topic>Wilms Tumor - secondary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marvin, M. R.</creatorcontrib><creatorcontrib>Kayton, M. L.</creatorcontrib><creatorcontrib>O'Toole, Kathleen M.</creatorcontrib><creatorcontrib>Rowe, Dorothy H.</creatorcontrib><creatorcontrib>DeRosa, Carolyn</creatorcontrib><creatorcontrib>Kindred, Amanda</creatorcontrib><creatorcontrib>Trokhan, S.</creatorcontrib><creatorcontrib>Chabot, J.</creatorcontrib><creatorcontrib>Kandel, Jessica J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marvin, M. R.</au><au>Kayton, M. L.</au><au>O'Toole, Kathleen M.</au><au>Rowe, Dorothy H.</au><au>DeRosa, Carolyn</au><au>Kindred, Amanda</au><au>Trokhan, S.</au><au>Chabot, J.</au><au>Kandel, Jessica J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Metastasizing Model of Anaplastic Human Wilms Tumor in the Nude Mouse</atitle><jtitle>European journal of pediatric surgery</jtitle><addtitle>Eur J Pediatr Surg</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>8</volume><issue>5</issue><spage>295</spage><epage>298</epage><pages>295-298</pages><issn>0939-7248</issn><eissn>1439-359X</eissn><abstract>Abstract
Reproducible animal models of Wilms tumor have been difficult to establish. We describe a model in which cells, banked from a patient with metastatic Wilms tumor, were implanted into nude mice, resulting in the development of primary renal and metastatic pulmonary lesions. Pathologically, the lesions resembled the blastemal component of anaplastic Wilms tumor. Primary tumors showed a significant propensity for growth in the kidney as opposed to other organs. Pulmonary metastases, histologically similar to the primary lesions, were regularly observed. This represents the first reproducible model of anaplastic, metastasizing human Wilms tumor. This system may prove effective for the study of factors influencing growth and angiogenesis in aggressive variants of Wilms tumor.</abstract><cop>Stuttgart</cop><pub>Thieme</pub><pmid>9825240</pmid><doi>10.1055/s-2008-1071217</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pediatric surgery, 1998-10, Vol.8 (5), p.295-298 |
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| language | eng |
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| subjects | Anaplasia Animals Biological and medical sciences Disease Models, Animal Female Humans Kidney Neoplasms - pathology Kidneys Medical sciences Mice Mice, Nude Neoplasm Metastasis Nephrology. Urinary tract diseases Original article Tumors of the urinary system Wilms Tumor - pathology Wilms Tumor - secondary |
| title | A Metastasizing Model of Anaplastic Human Wilms Tumor in the Nude Mouse |
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