Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats
Neurotropin is commonly used in Japan for the treatment of chronic pain. Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mec...
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| Veröffentlicht in: | Life sciences (1973) 1998-10, Vol.63 (21), p.1931-1938 |
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| container_end_page | 1938 |
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| container_issue | 21 |
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| container_title | Life sciences (1973) |
| container_volume | 63 |
| creator | Saleh, M.Ruksal Muneshige, Hiroshi Ikuta, Yoshikazu |
| description | Neurotropin is commonly used in Japan for the treatment of chronic pain. Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basile Plantar test and von Frey hairs test, respectively. Neurotropin reduced thermal hyperalgesia and produced an early recovery from hyperalgesia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. A possibility of differential drug sensitivity for thermal hyperalgesia and mechanical allodynia was indicated in this model, although the reason still remain elusive. |
| doi_str_mv | 10.1016/S0024-3205(98)00469-X |
| format | Article |
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Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basile Plantar test and von Frey hairs test, respectively. Neurotropin reduced thermal hyperalgesia and produced an early recovery from hyperalgesia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. 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Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basile Plantar test and von Frey hairs test, respectively. Neurotropin reduced thermal hyperalgesia and produced an early recovery from hyperalgesia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. A possibility of differential drug sensitivity for thermal hyperalgesia and mechanical allodynia was indicated in this model, although the reason still remain elusive.</description><subject>allodynia</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hot Temperature</subject><subject>hyperalgesia</subject><subject>Hyperalgesia - drug therapy</subject><subject>Ligation</subject><subject>Male</subject><subject>mononeuropathy</subject><subject>Nerve Crush</subject><subject>neurotropin</subject><subject>Pain - drug therapy</subject><subject>Pain Threshold - drug effects</subject><subject>Pain Threshold - physiology</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - physiopathology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOo7-BKEr0UU1z6ZZiQy-YMCFCu5Cmt44kU5Tk1aYf2_nwWxdXS7nnHsPH0IXBN8QTIrbN4wpzxnF4kqV1xjzQuWfB2hCSqlyXDByiCZ7ywk6TekbYyyEZMfoWJVUSEkmaP7gHNg-ZcFlLQwx9DF0vs1Cmy1WHUTTfEHyJjNtnZmmCfWqHbfRsAxt2AQ60y-8zaLp0xk6cqZJcL6bU_Tx-PA-e87nr08vs_t5brmQfS55URMrqaKKM0ErRRiHsQYpuOVOlNQxUdmipJIUlXW8chQcAKsrqogDxabocnu3i-FngNTrpU8Wmsa0EIakJcZjGpf_GolkBVm3mCKxNdoYUorgdBf90sSVJlivcesNbr1mqVWpN7j155i72D0YqiXU-9SO76jfbXUYcfx6iDpZD62F2scRu66D_-fDHz60kC8</recordid><startdate>19981016</startdate><enddate>19981016</enddate><creator>Saleh, M.Ruksal</creator><creator>Muneshige, Hiroshi</creator><creator>Ikuta, Yoshikazu</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19981016</creationdate><title>Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats</title><author>Saleh, M.Ruksal ; Muneshige, Hiroshi ; Ikuta, Yoshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-746d1c729294352b9134effe164c4f582f35bc682716bcf4bf2efee3db291fe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>allodynia</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hot Temperature</topic><topic>hyperalgesia</topic><topic>Hyperalgesia - drug therapy</topic><topic>Ligation</topic><topic>Male</topic><topic>mononeuropathy</topic><topic>Nerve Crush</topic><topic>neurotropin</topic><topic>Pain - drug therapy</topic><topic>Pain Threshold - drug effects</topic><topic>Pain Threshold - physiology</topic><topic>Polysaccharides - administration & dosage</topic><topic>Polysaccharides - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saleh, M.Ruksal</creatorcontrib><creatorcontrib>Muneshige, Hiroshi</creatorcontrib><creatorcontrib>Ikuta, Yoshikazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saleh, M.Ruksal</au><au>Muneshige, Hiroshi</au><au>Ikuta, Yoshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998-10-16</date><risdate>1998</risdate><volume>63</volume><issue>21</issue><spage>1931</spage><epage>1938</epage><pages>1931-1938</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Neurotropin is commonly used in Japan for the treatment of chronic pain. Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basile Plantar test and von Frey hairs test, respectively. Neurotropin reduced thermal hyperalgesia and produced an early recovery from hyperalgesia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. A possibility of differential drug sensitivity for thermal hyperalgesia and mechanical allodynia was indicated in this model, although the reason still remain elusive.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9825771</pmid><doi>10.1016/S0024-3205(98)00469-X</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | allodynia Analgesics - administration & dosage Analgesics - pharmacology Animals Behavior, Animal Disease Models, Animal Dose-Response Relationship, Drug Hot Temperature hyperalgesia Hyperalgesia - drug therapy Ligation Male mononeuropathy Nerve Crush neurotropin Pain - drug therapy Pain Threshold - drug effects Pain Threshold - physiology Polysaccharides - administration & dosage Polysaccharides - pharmacology Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Sciatic Nerve - physiopathology |
| title | Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats |
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