Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics
Previous studies have shown that the atypical neuroleptic clozapine is less potent at inducing Fos expression in the dorsolateral striatum than are typical neuroleptics. We report here that pretreatment with clozapine (5–20 mg/kg) actually attenuates the striatal Fos expression induced by the typica...
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| Veröffentlicht in: | European journal of pharmacology 1998-10, Vol.358 (3), p.R1-R3 |
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| container_title | European journal of pharmacology |
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| creator | Wirtshafter, David |
| description | Previous studies have shown that the atypical neuroleptic clozapine is less potent at inducing Fos expression in the dorsolateral striatum than are typical neuroleptics. We report here that pretreatment with clozapine (5–20 mg/kg) actually attenuates the striatal Fos expression induced by the typical neuroleptics haloperidol and raclopride. These results suggest clozapine has pharmacological properties which actively antagonize the effects of dopamine D2 receptor blockade on striatal immediate-early gene expression. |
| doi_str_mv | 10.1016/S0014-2999(98)00652-9 |
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We report here that pretreatment with clozapine (5–20 mg/kg) actually attenuates the striatal Fos expression induced by the typical neuroleptics haloperidol and raclopride. These results suggest clozapine has pharmacological properties which actively antagonize the effects of dopamine D2 receptor blockade on striatal immediate-early gene expression.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(98)00652-9</identifier><identifier>PMID: 9822897</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antipsychotic Agents - antagonists & inhibitors ; Antipsychotic Agents - pharmacology ; Atypical neuroleptic ; Biological and medical sciences ; c-Fos ; Clozapine - pharmacology ; Corpus Striatum - cytology ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Haloperidol - antagonists & inhibitors ; Haloperidol - pharmacology ; Immunohistochemistry ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Proto-Oncogene Proteins c-fos - biosynthesis ; Proto-Oncogene Proteins c-fos - drug effects ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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We report here that pretreatment with clozapine (5–20 mg/kg) actually attenuates the striatal Fos expression induced by the typical neuroleptics haloperidol and raclopride. These results suggest clozapine has pharmacological properties which actively antagonize the effects of dopamine D2 receptor blockade on striatal immediate-early gene expression.</description><subject>Animals</subject><subject>Antipsychotic Agents - antagonists & inhibitors</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Atypical neuroleptic</subject><subject>Biological and medical sciences</subject><subject>c-Fos</subject><subject>Clozapine - pharmacology</subject><subject>Corpus Striatum - cytology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Haloperidol - antagonists & inhibitors</subject><subject>Haloperidol - pharmacology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - drug effects</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Striatum</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq2qFV1oHwEpB1TBIWA7iR2fKrQqbSWkHoBeLa8zBldZO3iciuXp62VX9MhpDv_3z4w-Qo4ZPWeUiYsbSllbc6XUqerPKBUdr9U7smC9VDWVjL8ni1fkIzlE_EMp7RTvDsiB6jnvlVyQ38sxPpvJB6hMyOY-Bv8MWOUHqHwYZpt9DFV0FebkTTZjdRWxgqcpAeI2Wm2qvJm8LUmAOcURpuwtfiIfnBkRPu_nEbm7-na7_FFf__r-c3l5XdumV7mWnAvTCu761jYtMODGmcYNigojOROtWnWUtiClalfKGSqp7RruWjcIx5xsjsiX3d4pxccZMOu1RwvjaALEGbUsXkSxUMBuB9oUERM4PSW_NmmjGdVbn_rFp97K0qrXLz61Kr3j_YF5tYbhtbUXWPKTfW6wSHDJBOvx_3LBOkX7gn3dYVBk_PWQNFoPwcLgE9ish-jfeOQfNUmSqg</recordid><startdate>19981009</startdate><enddate>19981009</enddate><creator>Wirtshafter, David</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981009</creationdate><title>Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics</title><author>Wirtshafter, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7226a462f84c34e1e2afa3fd906a721649b5004e7794b9fa070c532f4fd6f1f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antipsychotic Agents - antagonists & inhibitors</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Atypical neuroleptic</topic><topic>Biological and medical sciences</topic><topic>c-Fos</topic><topic>Clozapine - pharmacology</topic><topic>Corpus Striatum - cytology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Haloperidol - antagonists & inhibitors</topic><topic>Haloperidol - pharmacology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Proto-Oncogene Proteins c-fos - drug effects</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wirtshafter, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wirtshafter, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1998-10-09</date><risdate>1998</risdate><volume>358</volume><issue>3</issue><spage>R1</spage><epage>R3</epage><pages>R1-R3</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Previous studies have shown that the atypical neuroleptic clozapine is less potent at inducing Fos expression in the dorsolateral striatum than are typical neuroleptics. We report here that pretreatment with clozapine (5–20 mg/kg) actually attenuates the striatal Fos expression induced by the typical neuroleptics haloperidol and raclopride. These results suggest clozapine has pharmacological properties which actively antagonize the effects of dopamine D2 receptor blockade on striatal immediate-early gene expression.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9822897</pmid><doi>10.1016/S0014-2999(98)00652-9</doi></addata></record> |
| fulltext | fulltext |
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| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antipsychotic Agents - antagonists & inhibitors Antipsychotic Agents - pharmacology Atypical neuroleptic Biological and medical sciences c-Fos Clozapine - pharmacology Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - metabolism Haloperidol - antagonists & inhibitors Haloperidol - pharmacology Immunohistochemistry Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - drug effects Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Striatum |
| title | Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics |
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