Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization

The immunotherapeutic effect of DNA-mediated immunization against chronic hepatitis B virus (HBV) infection has been evaluated in transgenic mice expressing the sequences that code for the envelope proteins of HBV in the liver. In this model of HBV chronic carriers, a single i.m. injection of plasmi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (10), p.5564-5570
Hauptverfasser:	Mancini, M, Hadchouel, M, Tiollais, P, Michel, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cytotoxicity, Immunologic DNA, Viral - immunology Female Gene Expression Regulation, Viral - immunology Hepatitis B Surface Antigens - genetics Hepatitis B Vaccines - genetics Hepatitis B Vaccines - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Immunophenotyping Injections, Intramuscular Interferon gamma Receptor Interferon-gamma - genetics Interferon-gamma - metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred Strains Mice, Knockout Mice, Transgenic - immunology Receptors, Interferon - deficiency Receptors, Interferon - genetics RNA, Messenger - biosynthesis RNA, Viral - biosynthesis T-Lymphocytes - metabolism Th1 Cells - immunology Transgenes - immunology Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Envelope Proteins - administration & dosage Viral Envelope Proteins - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!