Growth Inhibition of Cultured Human Tenon's Fibroblastic Cells by Targeting the E2F Transcription Factor

The transcription factor E2F regulates the expression of several genes concerned with cell growth. The ability to inhibit transcription by blocking E2F expression has great potential in the treatment of proliferative disorders. The effect of double-stranded phosphorothioate oligonucleotides containi...

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Veröffentlicht in:	Experimental eye research 1998-10, Vol.67 (4), p.395-401
Hauptverfasser:	AKIMOTO, MASAYUKI, HANGAI, MASANORI, OKAZAKI, KAZUSHIRO, KOGISHI, JUNICHI, HONDA, YOSHIHITO, KANEDA, YASUFUMI
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carrier Proteins Cell Culture Techniques Cell Cycle Proteins - genetics Cell Division - genetics cellular proliferation Connective Tissue Cells - cytology DNA - metabolism DNA-Binding Proteins E2F E2F Transcription Factors Eye - cytology Eye and associated structures. Visual pathways and centers. Vision Fibroblasts - cytology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Transfer Techniques Genes, cdc Humans HVJ-CL Liposomes Microscopy, Fluorescence phosphorothioate oligonucleotides decoy Respirovirus - genetics Retinoblastoma-Binding Protein 1 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics transcription factor Transcription Factor DP1 Transcription Factors - genetics Vertebrates: nervous system and sense organs
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